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    Apmap adipocyte plasma membrane associated protein [ Mus musculus (house mouse) ]

    Gene ID: 71881, updated on 12-May-2024

    Summary

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    Official Symbol
    Apmapprovided by MGI
    Official Full Name
    adipocyte plasma membrane associated proteinprovided by MGI
    Primary source
    MGI:MGI:1919131
    See related
    Ensembl:ENSMUSG00000033096 AllianceGenome:MGI:1919131
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310001A20Rik
    Summary
    Predicted to enable arylesterase activity. Predicted to be involved in biosynthetic process. Predicted to be located in cell surface and membrane. Is expressed in olfactory epithelium. Orthologous to human APMAP (adipocyte plasma membrane associated protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in kidney adult (RPKM 26.0), subcutaneous fat pad adult (RPKM 25.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Apmap in Genome Data Viewer
    Location:
    2 G3; 2 74.68 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (150425000..150450487, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (150583080..150608567, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ankyrin and armadillo repeat containing pseudogene Neighboring gene STARR-seq mESC enhancer starr_06007 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:150404413-150404596 Neighboring gene cystatin F (leukocystatin) Neighboring gene STARR-positive B cell enhancer ABC_E2647 Neighboring gene predicted gene, 52532 Neighboring gene acyl-CoA synthetase short-chain family member 1 Neighboring gene STARR-seq mESC enhancer starr_06012 Neighboring gene RIKEN cDNA E130215H24 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. APMAP interacts with lysyl oxidase-like proteins, and disruption of Apmap leads to beneficial visceral adipose tissue expansion. Pessentheiner AR, et al. FASEB J, 2017 Sep. PMID 28559441, Free PMC Article
    2. Identification of a novel integral plasma membrane protein induced during adipocyte differentiation. Albrektsen T, et al. Biochem J, 2001 Oct 15. PMID 11583587, Free PMC Article
    3. Reconstruction of gene association network reveals a transmembrane protein required for adipogenesis and targeted by PPARγ. Bogner-Strauss JG, et al. Cell Mol Life Sci, 2010 Dec. PMID 20552250, Free PMC Article
    4. The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in Alzheimer's disease. Gerber H, et al. Acta Neuropathol Commun, 2019 Jan 31. PMID 30704515, Free PMC Article
    5. Pancreatic islet and progenitor cell surface markers with cell sorting potential. Hald J, et al. Diabetologia, 2012 Jan. PMID 21947380

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data suggest that APMAP is a novel regulator of extracellular matrix components, and establish that APMAP is a potential target to mitigate obesity-associated insulin resistance.
      Title: APMAP interacts with lysyl oxidase-like proteins, and disruption of Apmap leads to beneficial visceral adipose tissue expansion.
    2. Data demonstrate that APMAP contains a functional PPARgamma binding site, and that APMAP translocates from the endoplasmatic reticulum to the plasma membrane during adipocyte differentiation
      Title: Reconstruction of gene association network reveals a transmembrane protein required for adipogenesis and targeted by PPARγ.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables arylesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arylesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables strictosidine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    adipocyte plasma membrane-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356491.1 → NP_001343420.1  adipocyte plasma membrane-associated protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL845174
      Conserved Domains (2) summary
      COG3386
      Location:1 → 243
      YvrE; Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]
      cl22863
      Location:124 → 211
      Str_synth; Strictosidine synthase

    2. NM_001356492.1 → NP_001343421.1  adipocyte plasma membrane-associated protein isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and uses an alternate splice junction compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL845174
      Conserved Domains (1) summary
      cl22863
      Location:5 → 92
      Str_synth; Strictosidine synthase

    3. NM_027977.3 → NP_082253.1  adipocyte plasma membrane-associated protein isoform 1

      See identical proteins and their annotated locations for NP_082253.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK009057, BY230335
      Consensus CDS
      CCDS16858.1
      UniProtKB/Swiss-Prot
      A2AQX3, Q3U4F4, Q9D7N9
      Related
      ENSMUSP00000040840.7, ENSMUST00000046399.7
      Conserved Domains (4) summary
      COG3386
      Location:72 → 319
      YvrE; Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]
      cd05819
      Location:101 → 136
      NHL; NHL repeat [structural motif]
      cl18310
      Location:95 → 283
      NHL; NHL repeat unit of beta-propeller proteins
      cl22863
      Location:200 → 287
      Str_synth; Strictosidine synthase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      150425000..150450487 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500198.4 → XP_006500261.1  adipocyte plasma membrane-associated protein isoform X1

      Conserved Domains (2) summary
      COG3386
      Location:33 → 280
      YvrE; Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]
      cl22863
      Location:161 → 248
      Str_synth; Strictosidine synthase

    2. XM_036162580.1 → XP_036018473.1  adipocyte plasma membrane-associated protein isoform X2

      Conserved Domains (1) summary
      cl22863
      Location:5 → 92
      Str_synth; Strictosidine synthase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D7N9.1 GenPept UniProtKB/Swiss-Prot:Q9D7N9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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