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    Tvp23b trans-golgi network vesicle protein 23B [ Mus musculus (house mouse) ]

    Gene ID: 67510, updated on 12-May-2024

    Summary

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    Official Symbol
    Tvp23bprovided by MGI
    Official Full Name
    trans-golgi network vesicle protein 23Bprovided by MGI
    Primary source
    MGI:MGI:1914760
    See related
    Ensembl:ENSMUSG00000014177 AllianceGenome:MGI:1914760
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam18b; Fam18b1; 1810036I24Rik
    Summary
    Predicted to be involved in protein secretion and vesicle-mediated transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of Golgi membrane. Is expressed in lung. Orthologous to several human genes including TVP23B (trans-golgi network vesicle protein 23 homolog B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 15.5), placenta adult (RPKM 15.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tvp23b in Genome Data Viewer
    Location:
    11 B2; 11 38.81 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (62770281..62786012)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (62879455..62895186)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing 16 Neighboring gene STARR-seq mESC enhancer starr_29718 Neighboring gene F-box and WD-40 domain protein 10 Neighboring gene STARR-seq mESC enhancer starr_29719 Neighboring gene STARR-positive B cell enhancer ABC_E1826 Neighboring gene trans-golgi network vesicle protein 23B, opposite strand Neighboring gene predicted gene, 36614

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Trans-Golgi protein TVP23B regulates host-microbe interactions via Paneth cell homeostasis and Goblet cell glycosylation. Song R, et al. Nat Commun, 2023 Jun 20. PMID 37339972, Free PMC Article
    2. Evolution of mammalian chitinase(-like) members of family 18 glycosyl hydrolases. Bussink AP, et al. Genetics, 2007 Oct. PMID 17720922, Free PMC Article
    3. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
    4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Trans-Golgi protein TVP23B regulates host-microbe interactions via Paneth cell homeostasis and Goblet cell glycosylation.
      Title: Trans-Golgi protein TVP23B regulates host-microbe interactions via Paneth cell homeostasis and Goblet cell glycosylation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Golgi apparatus membrane protein TVP23 homolog B
    Names
    family with sequence similarity 18, member B
    ortholog of human family with sequence similarity 18 member B FAM18B
    protein FAM18B1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356520.1 → NP_001343449.1  Golgi apparatus membrane protein TVP23 homolog B isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two consecutive alternate in-frame exons in the 3' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter, compared to isoform 1.
      Source sequence(s)
      AK007707, AK050027, AK077277, BP757155, CK334592
      Conserved Domains (1) summary
      pfam05832
      Location:32 → 130
      DUF846; Eukaryotic protein of unknown function (DUF846)

    2. NM_001356521.1 → NP_001343450.1  Golgi apparatus membrane protein TVP23 homolog B isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, uses a downstream start codon and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.
      Source sequence(s)
      AK007707, AK050027, BP757155, BY113761
      Conserved Domains (1) summary
      pfam05832
      Location:1 → 110
      DUF846; Eukaryotic protein of unknown function (DUF846)

    3. NM_026210.5 → NP_080486.1  Golgi apparatus membrane protein TVP23 homolog B isoform 1

      See identical proteins and their annotated locations for NP_080486.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK007707, AK050027, AK150936, BP757155
      Consensus CDS
      CCDS24834.1
      UniProtKB/Swiss-Prot
      Q3UBJ3, Q9D8T4
      Related
      ENSMUSP00000014321.5, ENSMUST00000014321.5
      Conserved Domains (1) summary
      pfam05832
      Location:32 → 174
      DUF846; Eukaryotic protein of unknown function (DUF846)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      62770281..62786012
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D8T4.1 GenPept UniProtKB/Swiss-Prot:Q9D8T4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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