U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Majin membrane anchored junction protein [ Mus musculus (house mouse) ]

    Gene ID: 622554, updated on 12-May-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Majinprovided by MGI
    Official Full Name
    membrane anchored junction proteinprovided by MGI
    Primary source
    MGI:MGI:1923913
    See related
    Ensembl:ENSMUSG00000024786 AllianceGenome:MGI:1923913
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700123I01Rik
    Summary
    Predicted to enable DNA binding activity. Involved in homologous chromosome pairing at meiosis and meiotic attachment of telomere to nuclear envelope. Located in chromosome, telomeric region. Is integral component of nuclear inner membrane. Orthologous to human MAJIN (membrane anchored junction protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 2.9) and large intestine adult (RPKM 0.2) See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Majin in Genome Data Viewer
    Location:
    19 A; 19 4.34 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6234358..6274349)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6184345..6224230)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted pseudogene 5510 Neighboring gene basic leucine zipper transcription factor, ATF-like 2 Neighboring gene protein phosphatase 2, regulatory subunit B', beta Neighboring gene STARR-positive B cell enhancer ABC_E9990 Neighboring gene STARR-positive B cell enhancer ABC_E5681 Neighboring gene glycoprotein hormone alpha 2 Neighboring gene STARR-positive B cell enhancer ABC_E619 Neighboring gene autophagy related 2A

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The TERB1-TERB2-MAJIN complex of mouse meiotic telomeres dates back to the common ancestor of metazoans. da Cruz I, et al. BMC Evol Biol, 2020 May 14. PMID 32408858, Free PMC Article
    2. Distinct TERB1 Domains Regulate Different Protein Interactions in Meiotic Telomere Movement. Zhang J, et al. Cell Rep, 2017 Nov 14. PMID 29141207
    3. CRISPR/Cas9-based genetic screen of SCNT-reprogramming resistant genes identifies critical genes for male germ cell development in mice. Akter MS, et al. Sci Rep, 2021 Jul 29. PMID 34326397, Free PMC Article
    4. Speedy A-Cdk2 binding mediates initial telomere-nuclear envelope attachment during meiotic prophase I independent of Cdk2 activation. Tu Z, et al. Proc Natl Acad Sci U S A, 2017 Jan 17. PMID 28031483, Free PMC Article
    5. MAJIN Links Telomeric DNA to the Nuclear Membrane by Exchanging Telomere Cap. Shibuya H, et al. Cell, 2015 Nov 19. PMID 26548954

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The TERB1-TERB2-MAJIN complex of mouse meiotic telomeres dates back to the common ancestor of metazoans.
      Title: The TERB1-TERB2-MAJIN complex of mouse meiotic telomeres dates back to the common ancestor of metazoans.
    2. The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope
      Title: The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope.
    3. Study identified meiosis-specific telomere and inner nuclear membrane-binding proteins, telomere repeat-binding bouquet formation protein 2 (TERB2) and membrane-anchored junction protein (MAJIN), which form a complex with TERB1.
      Title: MAJIN Links Telomeric DNA to the Nuclear Membrane by Exchanging Telomere Cap.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3)  1 citation
    • Targeted (1) 

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within double-strand break repair involved in meiotic recombination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in homologous chromosome pairing at meiosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within homologous chromosome pairing at meiosis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in homologous chromosome pairing at meiosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic attachment of telomere to nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within meiotic attachment of telomere to nuclear envelope IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in meiotic attachment of telomere to nuclear envelope IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within meiotic cell cycle process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic telomere clustering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    membrane-anchored junction protein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001165919.2 → NP_001159391.1  membrane-anchored junction protein isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC127556
      Consensus CDS
      CCDS50364.1
      UniProtKB/Swiss-Prot
      E9Q4N4, Q9D992
      UniProtKB/TrEMBL
      B2RQN5
      Related
      ENSMUSP00000109156.2, ENSMUST00000113528.2
      Conserved Domains (1) summary
      pfam15077
      Location:1 → 240
      MAJIN; Membrane-anchored junction protein

    2. NM_001377074.1 → NP_001364003.1  membrane-anchored junction protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC127556
      Conserved Domains (1) summary
      pfam15077
      Location:1 → 182
      MAJIN; Membrane-anchored junction protein

    3. NM_001377075.1 → NP_001364004.1  membrane-anchored junction protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC127556
      Related
      ENSMUSP00000025699.3, ENSMUST00000025699.9
      Conserved Domains (1) summary
      pfam15077
      Location:1 → 108
      MAJIN; Membrane-anchored junction protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      6234358..6274349
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161650.1 → XP_036017543.1  membrane-anchored junction protein isoform X2

      Conserved Domains (1) summary
      pfam15077
      Location:1 → 129
      MAJIN; Membrane-anchored junction protein

    2. XM_011248644.3 → XP_011246946.1  membrane-anchored junction protein isoform X1

      UniProtKB/TrEMBL
      B2RQN5
      Conserved Domains (1) summary
      pfam15077
      Location:14 → 221
      MAJIN; Membrane-anchored junction protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D992.2 GenPept UniProtKB/Swiss-Prot:Q9D992

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous