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    Slc9a7 solute carrier family 9 (sodium/hydrogen exchanger), member 7 [ Mus musculus (house mouse) ]

    Gene ID: 236727, updated on 8-May-2024

    Summary

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    Official Symbol
    Slc9a7provided by MGI
    Official Full Name
    solute carrier family 9 (sodium/hydrogen exchanger), member 7provided by MGI
    Primary source
    MGI:MGI:2444530
    See related
    Ensembl:ENSMUSG00000037341 AllianceGenome:MGI:2444530
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NHE7; 6330509M05Rik; A530087D17Rik
    Summary
    Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport; regulation of Golgi lumen acidification; and sodium ion import across plasma membrane. Predicted to act upstream of or within potassium ion transport. Predicted to be located in recycling endosome membrane and trans-Golgi network. Predicted to be integral component of membrane. Predicted to be active in plasma membrane and recycling endosome. Human ortholog(s) of this gene implicated in X-linked intellectual developmental disorder 108. Orthologous to human SLC9A7 (solute carrier family 9 member A7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cerebellum adult (RPKM 6.3), CNS E18 (RPKM 4.0) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc9a7 in Genome Data Viewer
    Location:
    X; X A1.3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (19965090..20158274, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (20098851..20292035, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene ribosomal protein L36, pseudogene 10 Neighboring gene STARR-seq mESC enhancer starr_46872 Neighboring gene STARR-seq mESC enhancer starr_46873 Neighboring gene predicted gene 5384 Neighboring gene STARR-seq mESC enhancer starr_46874 Neighboring gene carbohydrate sulfotransferase 7 Neighboring gene 40S ribosomal protein SA pseudogene Neighboring gene STARR-seq mESC enhancer starr_46875 Neighboring gene STARR-positive B cell enhancer ABC_E11046 Neighboring gene transcription initiation factor IIA subunit 1-like Neighboring gene high mobility group box 2 pseudogene Neighboring gene retinitis pigmentosa 2 homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Four Na+/H+ exchanger isoforms are distributed to Golgi and post-Golgi compartments and are involved in organelle pH regulation. Nakamura N, et al. J Biol Chem, 2005 Jan 14. PMID 15522866
    2. The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease. Willnow T, et al. Organogenesis, 2005 Apr. PMID 19521566, Free PMC Article
    3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NHE7 upregulation potentiates the uptake of small extracellular vesicles by enhancing maturation of macropinosomes in hepatocellular carcinoma.
      Title: NHE7 upregulation potentiates the uptake of small extracellular vesicles by enhancing maturation of macropinosomes in hepatocellular carcinoma.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium:proton antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium:proton antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sodium:proton antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium:proton antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic cation transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of Golgi lumen acidification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of intracellular pH IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of pH ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sodium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in recycling endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sodium/hydrogen exchanger 7
    Names
    Na(+)/H(+) exchanger 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177353.4 → NP_796327.1  sodium/hydrogen exchanger 7

      See identical proteins and their annotated locations for NP_796327.1

      Status: VALIDATED

      Source sequence(s)
      AL663098
      Consensus CDS
      CCDS40884.1
      UniProtKB/Swiss-Prot
      A2ACD5, A2ACD6, Q8BLV3
      Related
      ENSMUSP00000072274.5, ENSMUST00000072451.11
      Conserved Domains (1) summary
      TIGR00840
      Location:93 → 552
      b_cpa1; sodium/hydrogen exchanger 3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      19965090..20158274 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527617.4 → XP_006527680.1  sodium/hydrogen exchanger 7 isoform X2

      Conserved Domains (1) summary
      TIGR00840
      Location:93 → 595
      b_cpa1; sodium/hydrogen exchanger 3

    2. XM_006527616.4 → XP_006527679.1  sodium/hydrogen exchanger 7 isoform X1

      See identical proteins and their annotated locations for XP_006527679.1

      UniProtKB/Swiss-Prot
      A2ACD5, A2ACD6, Q8BLV3
      Conserved Domains (1) summary
      TIGR00840
      Location:93 → 552
      b_cpa1; sodium/hydrogen exchanger 3

    3. XM_030251315.1 → XP_030107175.1  sodium/hydrogen exchanger 7 isoform X2

      Conserved Domains (1) summary
      TIGR00840
      Location:93 → 595
      b_cpa1; sodium/hydrogen exchanger 3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BLV3.1 GenPept UniProtKB/Swiss-Prot:Q8BLV3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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