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    Aldh3b3 aldehyde dehydrogenase 3 family, member B3 [ Mus musculus (house mouse) ]

    Gene ID: 73458, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Aldh3b3provided by MGI
    Official Full Name
    aldehyde dehydrogenase 3 family, member B3provided by MGI
    Primary source
    MGI:MGI:1920708
    See related
    Ensembl:ENSMUSG00000037263 AllianceGenome:MGI:1920708
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700055N04Rik
    Summary
    Enables aldehyde dehydrogenase (NAD+) activity. Predicted to be involved in cellular aldehyde metabolic process. Located in cytoplasm and plasma membrane. Is expressed in olfactory epithelium; retina inner nuclear layer; retina layer; and retina outer nuclear layer. Orthologous to human ALDH3B1 (aldehyde dehydrogenase 3 family member B1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in bladder adult (RPKM 7.2), testis adult (RPKM 5.6) and 18 other tissues See more
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    Genomic context

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    See Aldh3b3 in Genome Data Viewer
    Location:
    19 A; 19 3.68 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (4008733..4022419)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (3958732..3972419)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene aldehyde dehydrogenase 3 family, member B1 Neighboring gene predicted gene, 42059 Neighboring gene STARR-positive B cell enhancer ABC_E7624 Neighboring gene unc-93 homolog B1, TLR signaling regulator Neighboring gene STARR-seq mESC enhancer starr_45335 Neighboring gene aldehyde dehydrogenase 3 family, member B2 Neighboring gene STARR-positive B cell enhancer ABC_E7625 Neighboring gene predicted gene, 52386 Neighboring gene aminoacylase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse aldehyde dehydrogenase ALDH3B2 is localized to lipid droplets via two C-terminal tryptophan residues and lipid modification. Kitamura T, et al. Biochem J, 2015 Jan 1. PMID 25286108
    2. Distinct roles of androgen receptor, estrogen receptor alpha, and BCL6 in the establishment of sex-biased DNA methylation in mouse liver. AlOgayil N, et al. Sci Rep, 2021 Jul 2. PMID 34215813, Free PMC Article
    3. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-chloroallyl aldehyde dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aldehyde dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aldehyde dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aldehyde dehydrogenase [NAD(P)+] activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular aldehyde metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cellular aldehyde metabolic process IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aldehyde dehydrogenase family 3 member B3
    NP_082821.2
    XP_006531905.1
    XP_006531906.1
    XP_006531907.1
    XP_006531908.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028545.2 → NP_082821.2  aldehyde dehydrogenase family 3 member B3

      Status: INFERRED

      Source sequence(s)
      AC133523
      Consensus CDS
      CCDS57128.1
      UniProtKB/Swiss-Prot
      J3QMK6, Q9D9K6
      Related
      ENSMUSP00000136334.2, ENSMUST00000179433.8
      Conserved Domains (1) summary
      cd07132
      Location:18 → 460
      ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      4008733..4022419
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531843.3 → XP_006531906.1  aldehyde dehydrogenase family 3 member B3 isoform X2

      Conserved Domains (1) summary
      cl11961
      Location:18 → 329
      ALDH-SF; NAD(P)+-dependent aldehyde dehydrogenase superfamily

    2. XM_006531844.5 → XP_006531907.1  aldehyde dehydrogenase family 3 member B3 isoform X3

      Conserved Domains (1) summary
      cl11961
      Location:18 → 329
      ALDH-SF; NAD(P)+-dependent aldehyde dehydrogenase superfamily

    3. XM_006531845.5 → XP_006531908.1  aldehyde dehydrogenase family 3 member B3 isoform X4

      Conserved Domains (1) summary
      cl11961
      Location:18 → 329
      ALDH-SF; NAD(P)+-dependent aldehyde dehydrogenase superfamily

    4. XM_006531842.3 → XP_006531905.1  aldehyde dehydrogenase family 3 member B3 isoform X1

      Conserved Domains (1) summary
      cl11961
      Location:18 → 418
      ALDH-SF; NAD(P)+-dependent aldehyde dehydrogenase superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    J3QMK6.1 GenPept UniProtKB/Swiss-Prot:J3QMK6

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