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    Ppp1r14d protein phosphatase 1, regulatory inhibitor subunit 14D [ Mus musculus (house mouse) ]

    Gene ID: 72112, updated on 12-May-2024

    Summary

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    Official Symbol
    Ppp1r14dprovided by MGI
    Official Full Name
    protein phosphatase 1, regulatory inhibitor subunit 14Dprovided by MGI
    Primary source
    MGI:MGI:1919362
    See related
    Ensembl:ENSMUSG00000027317 AllianceGenome:MGI:1919362
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GBPI-1; Ppp1r14; 2010107K19Rik
    Summary
    Predicted to enable protein serine/threonine phosphatase inhibitor activity. Predicted to be involved in negative regulation of protein serine/threonine phosphatase activity and positive regulation of protein serine/threonine phosphatase activity. Predicted to be located in cytoplasm. Orthologous to human PPP1R14D (protein phosphatase 1 regulatory inhibitor subunit 14D). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in large intestine adult (RPKM 112.3), small intestine adult (RPKM 50.9) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ppp1r14d in Genome Data Viewer
    Location:
    2 E5; 2 59.97 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (119048600..119060557, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (119218119..119230076, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C17 Neighboring gene STARR-positive B cell enhancer ABC_E5968 Neighboring gene 40S ribosomal protein S6 (Phosphoprotein NP33) Neighboring gene STARR-seq mESC enhancer starr_05476 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:119034498-119034685 Neighboring gene zinc finger, FYVE domain containing 19 Neighboring gene serine protease inhibitor, Kunitz type 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:119076669-119076852 Neighboring gene STARR-seq mESC enhancer starr_05478 Neighboring gene ras homolog family member V

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. GBPI, a novel gastrointestinal- and brain-specific PP1-inhibitory protein, is activated by PKC and inactivated by PKA. Liu QR, et al. Biochem J, 2004 Jan 1. PMID 12974676, Free PMC Article
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein phosphatase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of protein serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase 1 regulatory subunit 14D
    Names
    PKC-dependent PP1 inhibitory protein subunit 14
    gastrointestinal and brain-specific PP1-inhibitory protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290796.1 → NP_001277725.1  protein phosphatase 1 regulatory subunit 14D isoform a

      See identical proteins and their annotated locations for NP_001277725.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK008348, AL929318, AY179331
      Consensus CDS
      CCDS71118.1
      UniProtKB/Swiss-Prot
      Q7TT52
      Related
      ENSMUSP00000106444.3, ENSMUST00000110820.3
      Conserved Domains (1) summary
      pfam05361
      Location:53 → 85
      PP1_inhibitor; PKC-activated protein phosphatase-1 inhibitor

    2. NM_028104.4 → NP_082380.1  protein phosphatase 1 regulatory subunit 14D isoform b

      See identical proteins and their annotated locations for NP_082380.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AK008348, AL929318
      Consensus CDS
      CCDS16596.1
      UniProtKB/Swiss-Prot
      A2AV57, Q7TT52, Q9D878
      Related
      ENSMUSP00000075453.6, ENSMUST00000076084.6
      Conserved Domains (1) summary
      pfam05361
      Location:53 → 140
      PP1_inhibitor; PKC-activated protein phosphatase-1 inhibitor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      119048600..119060557 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239782.3 → XP_011238084.1  protein phosphatase 1 regulatory subunit 14D isoform X1

      Conserved Domains (1) summary
      pfam05361
      Location:53 → 85
      PP1_inhibitor; PKC-activated protein phosphatase-1 inhibitor

    2. XM_011239783.3 → XP_011238085.1  protein phosphatase 1 regulatory subunit 14D isoform X2

      Conserved Domains (2) summary
      COG2936
      Location:21 → 97
      COG2936; Predicted acyl esterase [General function prediction only]
      pfam05361
      Location:53 → 85
      PP1_inhibitor; PKC-activated protein phosphatase-1 inhibitor
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TT52.2 GenPept UniProtKB/Swiss-Prot:Q7TT52

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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