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    Xlr X-linked lymphocyte-regulated [ Mus musculus (house mouse) ]

    Gene ID: 22441, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Xlrprovided by MGI
    Official Full Name
    X-linked lymphocyte-regulatedprovided by MGI
    Primary source
    MGI:MGI:98976
    See related
    Ensembl:ENSMUSG00000054626 AllianceGenome:MGI:98976
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to be involved in meiotic cell cycle and spermatogenesis, exchange of chromosomal proteins. Predicted to be located in lateral element. Predicted to be active in synaptonemal complex. Is expressed in germ cell of testis; gonad; and testis. Human ortholog(s) of this gene implicated in spermatogenic failure 4. Orthologous to human SYCP3 (synaptonemal complex protein 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in placenta adult (RPKM 1.3), liver E14 (RPKM 0.3) and 10 other tissues See more
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    Genomic context

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    See Xlr in Genome Data Viewer
    Location:
    X A5; X 30.06 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (52779084..52799673, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (53777118..53797716, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted pseudogene 6025 Neighboring gene zinc finger protein 36, C3H type-like 3 Neighboring gene 60S ribosomal protein L37 pseudogene Neighboring gene X-linked lymphocyte-regulated complex pseudogene Neighboring gene predicted gene, 38663

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sequence analysis and expression of an X-linked, lymphocyte-regulated gene family (XLR). Siegel JN, et al. J Exp Med, 1987 Dec 1. PMID 3681192, Free PMC Article
    2. Ectopic expression of X-linked lymphocyte-regulated protein pM1 renders tumor cells resistant to antitumor immunity. Kang TH, et al. Cancer Res, 2010 Apr 15. PMID 20395201, Free PMC Article
    3. Sex-specific gene expression during meiotic prophase I: Xlr (X linked, lymphocyte regulated), not its male homologue Xmr (Xlr related, meiosis regulated), is expressed in mouse oocytes. Escalier D, et al. Biol Reprod, 2002 Nov. PMID 12390899
    4. The XLR sequence family: dispersion on the X and Y chromosomes of a large set of closely related sequences, most of which are pseudogenes. Garchon HJ, et al. Nucleic Acids Res, 1989 Dec 11. PMID 2602144, Free PMC Article
    5. The meiosis-specific Xmr gene product is homologous to the lymphocyte Xlr protein and is a component of the XY body. Calenda A, et al. EMBO J, 1994 Jan 1. PMID 8306953, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. X-linked lymphocyte-regulated protein pM1 (XMR), XLR, and SCP3 render tumor cells resistant to antitumor immunity
      Title: Ectopic expression of X-linked lymphocyte-regulated protein pM1 renders tumor cells resistant to antitumor immunity.
    2. Xlr (X linked, lymphocyte regulated) was expressed in oocytes throughout meiotic prophase I. These findings indicate a sex-specific expression of two closely related members of the Xlr gene family during meiotic prophase I.
      Title: Sex-specific gene expression during meiotic prophase I: Xlr (X linked, lymphocyte regulated), not its male homologue Xmr (Xlr related, meiosis regulated), is expressed in mouse oocytes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatid development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in synaptonemal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    X-linked lymphocyte-regulated protein PM1
    Names
    X-linked gene family of B-cell surface antigens
    X-linked lymphocyte-regulated complex

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291747.2 → NP_001278676.1  X-linked lymphocyte-regulated protein PM1 isoform a

      See identical proteins and their annotated locations for NP_001278676.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-8 all encode the same isoform (a).
      Source sequence(s)
      AL691513
      Consensus CDS
      CCDS30139.1
      UniProtKB/Swiss-Prot
      P05531
      UniProtKB/TrEMBL
      Q544L6
      Related
      ENSMUSP00000110458.2, ENSMUST00000114810.2
      Conserved Domains (1) summary
      pfam04803
      Location:61 → 192
      Cor1; Cor1/Xlr/Xmr conserved region

    2. NM_001291748.1 → NP_001278677.1  X-linked lymphocyte-regulated protein PM1 isoform b

      See identical proteins and their annotated locations for NP_001278677.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, the 3' UTR, and the 3' coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 3, 9, and 10 all encode the same isoform (b).
      Source sequence(s)
      AK035025, AL691513
      Consensus CDS
      CCDS81127.1
      UniProtKB/TrEMBL
      Q8BS74
      Related
      ENSMUSP00000066162.2, ENSMUST00000067782.8
      Conserved Domains (1) summary
      pfam04803
      Location:63 → 162
      Cor1; Cor1/Xlr/Xmr conserved region

    3. NM_001426070.1 → NP_001412999.1  X-linked lymphocyte-regulated protein PM1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL691513
      UniProtKB/Swiss-Prot
      P05531
      UniProtKB/TrEMBL
      Q544L6

    4. NM_001426071.1 → NP_001413000.1  X-linked lymphocyte-regulated protein PM1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL691513
      UniProtKB/Swiss-Prot
      P05531
      UniProtKB/TrEMBL
      Q544L6

    5. NM_001426072.1 → NP_001413001.1  X-linked lymphocyte-regulated protein PM1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL691513
      UniProtKB/Swiss-Prot
      P05531
      UniProtKB/TrEMBL
      Q544L6

    6. NM_001426073.1 → NP_001413002.1  X-linked lymphocyte-regulated protein PM1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL691513
      UniProtKB/Swiss-Prot
      P05531
      UniProtKB/TrEMBL
      Q544L6

    7. NM_001426074.1 → NP_001413003.1  X-linked lymphocyte-regulated protein PM1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL691513
      UniProtKB/Swiss-Prot
      P05531
      UniProtKB/TrEMBL
      Q544L6

    8. NM_001426075.1 → NP_001413004.1  X-linked lymphocyte-regulated protein PM1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL691513
      UniProtKB/TrEMBL
      Q8BS74

    9. NM_001426076.1 → NP_001413005.1  X-linked lymphocyte-regulated protein PM1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL691513
      UniProtKB/TrEMBL
      Q8BS74

    10. NM_011725.5 → NP_035855.1  X-linked lymphocyte-regulated protein PM1 isoform a

      See identical proteins and their annotated locations for NP_035855.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2, and 4-8 all encode the same isoform (a).
      Source sequence(s)
      AL691513
      Consensus CDS
      CCDS30139.1
      UniProtKB/Swiss-Prot
      P05531
      UniProtKB/TrEMBL
      Q544L6
      Related
      ENSMUSP00000068044.4, ENSMUST00000067763.10
      Conserved Domains (1) summary
      pfam04803
      Location:61 → 192
      Cor1; Cor1/Xlr/Xmr conserved region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      52779084..52799673 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P05531.1 GenPept UniProtKB/Swiss-Prot:P05531

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