Rln3 relaxin 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rln3provided by MGI
Official Full Name: relaxin 3provided by MGI
Primary source: MGI:MGI:2158015
See related: Ensembl:ENSMUSG00000045232 AllianceGenome:MGI:2158015
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: M3; insl7
Summary: Predicted to enable G protein-coupled receptor binding activity. Predicted to be located in extracellular region. Is expressed in brain and gonad. Orthologous to human RLN3 (relaxin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 3.0), thymus adult (RPKM 2.9) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 C2; 8 40.26 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (84769696..84771608, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (84043067..84044979, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mapping Cell Types and Efferent Pathways in the Ascending Relaxin-3 System of the Nucleus Incertus.
Title: Mapping Cell Types and Efferent Pathways in the Ascending Relaxin-3 System of the Nucleus Incertus.
Results indicate endogenous RLN3/RXFP3 signaling can modulate hippocampal-dependent spatial reference and working memory via effects on somatostatin interneurons, and further our knowledge of hippocampal cognitive processing
Title: Relaxin-3 inputs target hippocampal interneurons and deletion of hilar relaxin-3 receptors in "floxed-RXFP3" mice impairs spatial memory.
That endogenous relaxin-3-RXFP3 signalling is a powerful mediator of salt appetite in mice.
Title: Involvement of central relaxin-3 signalling in sodium (salt) appetite.
Relaxin-3 knockout mice exhibit mild anxiolytic characteristics relative to wild-type mice, suggesting that this peptide is involved in anxiety-related behavior.
Title: Behavioral analysis of relaxin-3 deficient mice.
Central injection of the RXFP3 agonists R3/I5 or H3 relaxin (0.5 nmol, icv) did not alter chow consumption in satiated mice relative to vehicle controls, during the 60 min after treatment.
Title: Pharmacological activation of RXFP3 is not orexigenic in C57BL/6J mice.
These preliminary studies suggest an interaction between relaxin-3 and ventrolateral preoptic galanin neurons that may contribute to the arousal-promoting action of relaxin-3.
Title: Potential hypothalamic targets of relaxin-3 innervation: a perspective.
These findings are consistent with an earlier report of increased activity scores in rats acutely injected centrally with R3/I5, and further suggest a role for relaxin-3/RXFP3 signalling in promoting behavioural arousal.
Title: Viral-mediated delivery of an RXFP3 agonist into brain promotes arousal in mice.
The present study compared the ability of relaxin-3 deficient (null mutation) and C57BL/6J wildtype littermate mice to entrain daily running wheel activity to timed food availability.
Title: Consequences of relaxin-3 null mutation in mice on food-entrainable arousal.
These studies support a role for relaxin-3 signaling in the control of arousal and sleep/wakefulness, and identify the relaxin-3 KO mouse as a useful model to study this role further.
Title: Relaxin-3 null mutation mice display a circadian hypoactivity phenotype.
Data provide evidence for the conserved nature of RLN3/RXFP3 systems in mammalian brain and the ability of RLN3/RXFP3 signaling to modulate "behavioral state" and an array of circuits involved in arousal, stress, affect, and cognition.
Title: Distribution of relaxin-3 and RXFP3 within arousal, stress, affective, and cognitive circuits of mouse brain.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (4) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor binding	ISO Inferred from Sequence Orthology more info
enables hormone activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: relaxin-3

Names: insulin-like 7; insulin-like peptide 7; insulin-like peptide INSL7; prorelaxin M3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173184.1 → NP_775276.1 relaxin-3 precursor

See identical proteins and their annotated locations for NP_775276.1

Status: PROVISIONAL

Source sequence(s)

AB076565

Consensus CDS

CCDS22466.1

UniProtKB/Swiss-Prot

Q8CHK2

Related

ENSMUSP00000051392.4, ENSMUST00000061923.5

Conserved Domains (1) summary

cd04365
Location:30 → 141

IlGF_relaxin_like; IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4), ...