Kremen2 kringle containing transmembrane protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kremen2provided by MGI
Official Full Name: kringle containing transmembrane protein 2provided by MGI
Primary source: MGI:MGI:1920266
See related: Ensembl:ENSMUSG00000040680 AllianceGenome:MGI:1920266
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Krm2; 2900054E04Rik
Summary: Involved in limb development and negative regulation of ossification. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including reproductive system; sensory organ; skeletal musculature; skin; and tooth. Orthologous to human KREMEN2 (kringle containing transmembrane protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in limb E14.5 (RPKM 15.8), colon adult (RPKM 11.2) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 12.03 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (23960173..23965305, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (23741199..23745960, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kremen2 drives the progression of non-small cell lung cancer by preventing SOCS3-mediated degradation of EGFR.
Title: Kremen2 drives the progression of non-small cell lung cancer by preventing SOCS3-mediated degradation of EGFR.
Kremen2 antagonizes the apoptotic activity of Kremen1
Title: Kremen1-induced cell death is regulated by homo- and heterodimerization.
The dysregulated collagen metabolic process, ECM-receptor interaction and p53 signaling pathway may be responsible for impaired fracture healing of osteoporotic Krm2 transgenic mice.
Title: Bioinformatics analysis of gene expression profile in callus tissues of osteoporotic phenotype mice induced by osteoblast-specific Krm2 overexpression.
Bone formation was more reduced in Col1a1-Krm2 than in Lrp5-/- mice, whereas osteoclast number was similarly increased in both genotypes in comparison with wild-type mice
Title: Osteoblast-specific Krm2 overexpression and Lrp5 deficiency have different effects on fracture healing in mice.
effects of Krm2 on bone remodeling
Title: Negative regulation of bone formation by the transmembrane Wnt antagonist Kremen-2.
Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling.
Title: Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:491493

UniSTS:496615 (e-PCR)
- UniSTS:496615

Kremen2 (e-PCR), detects polymorphism
- UniSTS:496615

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in limb development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of ossification	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: kremen protein 2

Names: dickkopf receptor 2; kringle domain-containing transmembrane protein 2; kringle-containing protein marking the eye and the nose

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028416.2 → NP_082692.1 kremen protein 2 precursor

See identical proteins and their annotated locations for NP_082692.1

Status: VALIDATED

Source sequence(s)

AJ457192

Consensus CDS

CCDS28462.1

UniProtKB/Swiss-Prot

Q0VBR6, Q8K1S7

Related

ENSMUSP00000046369.9, ENSMUST00000046525.10

Conserved Domains (3) summary

smart00130
Location:33 → 118

KR; Kringle domain

cd00041
Location:218 → 323

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

pfam01822
Location:124 → 204

WSC; WSC domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

23960173..23965305 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036160796.1 → XP_036016689.1 kremen protein 2 isoform X2

UniProtKB/Swiss-Prot

Q0VBR6, Q8K1S7

Conserved Domains (3) summary

smart00130
Location:33 → 118

KR; Kringle domain

cd00041
Location:218 → 323

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

pfam01822
Location:124 → 204

WSC; WSC domain
XM_006524983.5 → XP_006525046.3 kremen protein 2 isoform X1

Conserved Domains (3) summary

smart00130
Location:102 → 187

KR; Kringle domain

cd00041
Location:287 → 392

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

pfam01822
Location:192 → 273

WSC; WSC domain
XM_006524984.4 → XP_006525047.1 kremen protein 2 isoform X2

See identical proteins and their annotated locations for XP_006525047.1

UniProtKB/Swiss-Prot

Q0VBR6, Q8K1S7

Conserved Domains (3) summary

smart00130
Location:33 → 118

KR; Kringle domain

cd00041
Location:218 → 323

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

pfam01822
Location:124 → 204

WSC; WSC domain
XM_036160797.1 → XP_036016690.1 kremen protein 2 isoform X3

Conserved Domains (2) summary

smart00130
Location:102 → 187

KR; Kringle domain

cl02568
Location:193 → 230

WSC; WSC domain