Gfral GDNF family receptor alpha like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gfralprovided by MGI
Official Full Name: GDNF family receptor alpha likeprovided by MGI
Primary source: MGI:MGI:3607786
See related: Ensembl:ENSMUSG00000059383 AllianceGenome:MGI:3607786
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gral
Summary: Enables glial cell-derived neurotrophic factor receptor activity and receptor tyrosine kinase binding activity. Involved in positive regulation of MAPK cascade and reduction of food intake in response to dietary excess. Acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of neuron apoptotic process; and stress-activated protein kinase signaling cascade. Located in plasma membrane. Orthologous to human GFRAL (GDNF family receptor alpha like). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 9 D; 9 42.48 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (76071389..76120939, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (76164102..76213657, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fatty Acids Increase GDF15 and Reduce Food Intake Through a GFRAL Signaling Axis.
Title: Fatty Acids Increase GDF15 and Reduce Food Intake Through a GFRAL Signaling Axis.
The GDF15-GFRAL axis mediates chemotherapy-induced fatigue in mice.
Title: The GDF15-GFRAL axis mediates chemotherapy-induced fatigue in mice.
Macrophage inhibitory cytokine-1 promotes angiogenesis by eliciting the GFRAL-mediated endothelial cell signaling.
Title: Macrophage inhibitory cytokine-1 promotes angiogenesis by eliciting the GFRAL-mediated endothelial cell signaling.
Investigated the role of the growth differentiation factor 15 (GDF15) - glial derived neurotrophic factor receptor alpha-like (GFRAL) pathway in the physiological regulation of body weight and metabolism.
Title: GDF15 mediates adiposity resistance through actions on GFRAL neurons in the hindbrain AP/NTS.
isolating GFRAL as the receptor for GDF15-induced anorexia and weight loss, the identification of a mechanistic basis for the non-homeostatic regulation of neural circuitry by a peripheral signal associated with tissue damage and stress; findings provide opportunities to develop therapeutic agents for the treatment of disorders with altered energy demand
Title: Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (8) 1 citation
Targeted (3) 1 citation

General gene information

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Markers

contig_359087 (e-PCR)
- UniSTS:517160

MHAa70g6.seq (e-PCR)
- UniSTS:125295

NoName (e-PCR)
- UniSTS:495730

NoName (e-PCR)
- UniSTS:487852

17.MHAa96b5.seq (e-PCR)
- UniSTS:123330

NoName (e-PCR)
- UniSTS:488673

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables glial cell-derived neurotrophic factor receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables glial cell-derived neurotrophic factor receptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor tyrosine kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in GDF15-GFRAL signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in GDF15-GFRAL signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in GDF15-GFRAL signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in glial cell-derived neurotrophic factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of appetite	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of appetite	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in reduction of food intake in response to dietary excess	IDA Inferred from Direct Assay more info	PubMed
involved_in reduction of food intake in response to dietary excess	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to metformin	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within stress-activated protein kinase signaling cascade	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: GDNF family receptor alpha-like

Names: GDNF receptor alpha-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.