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    Eif4e1b eukaryotic translation initiation factor 4E family member 1B [ Mus musculus (house mouse) ]

    Gene ID: 218268, updated on 12-May-2024

    Summary

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    Official Symbol
    Eif4e1bprovided by MGI
    Official Full Name
    eukaryotic translation initiation factor 4E family member 1Bprovided by MGI
    Primary source
    MGI:MGI:2685119
    See related
    Ensembl:ENSMUSG00000074895 AllianceGenome:MGI:2685119
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm273; Eif4eloo
    Summary
    Predicted to enable RNA 7-methylguanosine cap binding activity and translation initiation factor activity. Predicted to act upstream of or within translational initiation. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 4F complex. Is expressed in oocyte and testis. Orthologous to human EIF4E1B (eukaryotic translation initiation factor 4E family member 1B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward ovary adult (RPKM 4.5) See more
    Orthologs
    human all
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    Genomic context

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    See Eif4e1b in Genome Data Viewer
    Location:
    13 B1; 13 29.39 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (54931807..54936272)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (54783994..54788459)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene synuclein, beta Neighboring gene STARR-seq mESC enhancer starr_34592 Neighboring gene predicted gene 16249 Neighboring gene STARR-positive B cell enhancer mm9_chr13:54890539-54890840 Neighboring gene tetraspanin 17 Neighboring gene predicted gene, 40959

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Germ cell-specific eIF4E1b regulates maternal mRNA translation to ensure zygotic genome activation. Yang G, et al. Genes Dev, 2023 May 1. PMID 37257918, Free PMC Article
    2. Selective Translation of Maternal mRNA by eIF4E1B Controls Oocyte to Embryo Transition. Guo J, et al. Adv Sci (Weinh), 2023 Apr. PMID 36755190, Free PMC Article
    3. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. eIF4E1b is a non-canonical eIF4E protecting maternal dormant mRNAs.
      Title: eIF4E1b is a non-canonical eIF4E protecting maternal dormant mRNAs.
    2. Germ cell-specific eIF4E1b regulates maternal mRNA translation to ensure zygotic genome activation.
      Title: Germ cell-specific eIF4E1b regulates maternal mRNA translation to ensure zygotic genome activation.
    3. Selective Translation of Maternal mRNA by eIF4E1B Controls Oocyte to Embryo Transition.
      Title: Selective Translation of Maternal mRNA by eIF4E1B Controls Oocyte to Embryo Transition.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (7)  1 citation
    • Targeted (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA 7-methylguanosine cap binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 4F complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 4E type 1B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033269.3 → NP_001028441.1  eukaryotic translation initiation factor 4E type 1B isoform 1

      See identical proteins and their annotated locations for NP_001028441.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      DQ279473, DV659735
      Consensus CDS
      CCDS49269.1
      UniProtKB/Swiss-Prot
      Q27ZJ1, Q3UTA9
      UniProtKB/TrEMBL
      E9Q0M0
      Related
      ENSMUSP00000123294.2, ENSMUST00000132728.8
      Conserved Domains (1) summary
      pfam01652
      Location:66 → 225
      IF4E; Eukaryotic initiation factor 4E

    2. NM_001039683.2 → NP_001034772.1  eukaryotic translation initiation factor 4E type 1B isoform 2

      See identical proteins and their annotated locations for NP_001034772.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift and early stop codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      DQ279473, DQ279474, DV659735
      Consensus CDS
      CCDS49270.1
      UniProtKB/Swiss-Prot
      Q3UTA9
      Related
      ENSMUSP00000120619.2, ENSMUST00000152204.3
      Conserved Domains (1) summary
      pfam01652
      Location:66 → 161
      IF4E; Eukaryotic initiation factor 4E

    3. NM_001286178.1 → NP_001273107.1  eukaryotic translation initiation factor 4E type 1B isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5'-terminal exon, and initiates translation from an alternate start codon, compared to variant 1. The encoded isoform (3) has a longer N-terminus, compared to isoform 1.
      Source sequence(s)
      DQ279473, DV653822, DV659735
      UniProtKB/TrEMBL
      E9Q0M0
      Related
      ENSMUSP00000117092.2, ENSMUST00000142158.8
      Conserved Domains (1) summary
      pfam01652
      Location:74 → 230
      IF4E; Eukaryotic initiation factor 4E

    4. NM_001286179.1 → NP_001273108.1  eukaryotic translation initiation factor 4E type 1B isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 5'-terminal exon, and initiates translation from an alternate start codon, compared to variant 1. The encoded isoform (4) has a longer N-terminus, compared to isoform 1.
      Source sequence(s)
      DQ279473, DV659735, DV662251
      Consensus CDS
      CCDS70460.1
      UniProtKB/TrEMBL
      E9PVZ9, E9Q0M0
      Related
      ENSMUSP00000118697.3, ENSMUST00000126785.8
      Conserved Domains (1) summary
      pfam01652
      Location:75 → 231
      IF4E; Eukaryotic initiation factor 4E

    5. NM_001286180.1 → NP_001273109.1  eukaryotic translation initiation factor 4E type 1B isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses alternate splice sites in the 5'-terminal exon and in the 3' coding region, and initiates translation from an alternate start codon, compared to variant 1. The encoded isoform (5) has a longer N-terminus and a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      DQ279473, DV659735, DV662389
      Consensus CDS
      CCDS70459.1
      UniProtKB/TrEMBL
      E9Q929
      Related
      ENSMUSP00000116681.2, ENSMUST00000132005.8
      Conserved Domains (1) summary
      pfam01652
      Location:74 → 166
      IF4E; Eukaryotic initiation factor 4E

    RNA

    1. NR_104406.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) has multiple differences in the 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      DQ279473, DQ279478, DV659735

    2. NR_104407.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks two internal exons and contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      DQ279473, DQ279479, DV659735

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      54931807..54936272
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315485.2 → XP_017170974.1  eukaryotic translation initiation factor 4E type 1B isoform X1

      UniProtKB/Swiss-Prot
      Q27ZJ1, Q3UTA9
      UniProtKB/TrEMBL
      E9Q0M0
      Related
      ENSMUSP00000105630.3, ENSMUST00000110003.9
      Conserved Domains (1) summary
      pfam01652
      Location:66 → 225
      IF4E; Eukaryotic initiation factor 4E

    2. XM_017315486.2 → XP_017170975.1  eukaryotic translation initiation factor 4E type 1B isoform X2

      UniProtKB/Swiss-Prot
      Q3UTA9
      Conserved Domains (1) summary
      pfam01652
      Location:66 → 161
      IF4E; Eukaryotic initiation factor 4E
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UTA9.1 GenPept UniProtKB/Swiss-Prot:Q3UTA9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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