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    Ubxn1 UBX domain protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 225896, updated on 3-Jun-2024

    Summary

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    Official Symbol
    Ubxn1provided by MGI
    Official Full Name
    UBX domain protein 1provided by MGI
    Primary source
    MGI:MGI:1289301
    See related
    Ensembl:ENSMUSG00000071655 AllianceGenome:MGI:1289301
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2B28; mY33K; D19Ertd721e; 4930455J02Rik
    Summary
    Predicted to enable several functions, including enzyme binding activity; polyubiquitin modification-dependent protein binding activity; and proteasome regulatory particle binding activity. Predicted to be involved in negative regulation of cellular protein metabolic process. Predicted to be located in several cellular components, including dendrite; neuronal cell body; and nucleoplasm. Predicted to be part of VCP-NPL4-UFD1 AAA ATPase complex. Is expressed in pancreas epithelium. Orthologous to human UBXN1 (UBX domain protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 89.4), CNS E11.5 (RPKM 86.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ubxn1 in Genome Data Viewer
    Location:
    19 A; 19 5.88 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (8848912..8853030)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (8871548..8875666)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene BSCL2 lipid droplet biogenesis associated, seipin Neighboring gene guanine nucleotide binding protein (G protein), gamma 3 Neighboring gene LRRN4 C-terminal like Neighboring gene STARR-seq mESC enhancer starr_45500 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:8955290-8955473 Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 3 Neighboring gene RIKEN cDNA 5730408K05 gene Neighboring gene STARR-positive B cell enhancer ABC_E11017 Neighboring gene LBH domain containing 1 Neighboring gene small nucleolar RNA, H/ACA box 57

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel protein specifically interacting with Homer2 regulates ubiquitin-proteasome systems. Ishibashi T, et al. J Biochem, 2005 May. PMID 15944415
    2. The AAA ATPase p97 links peptide N-glycanase to the endoplasmic reticulum-associated E3 ligase autocrine motility factor receptor. Li G, et al. Proc Natl Acad Sci U S A, 2006 May 30. PMID 16709668, Free PMC Article
    3. Identification of proteins that interact with mammalian peptide:N-glycanase and implicate this hydrolase in the proteasome-dependent pathway for protein degradation. Park H, et al. Proc Natl Acad Sci U S A, 2001 Sep 25. PMID 11562482, Free PMC Article
    4. An 'equalized cDNA library' by the reassociation of short double-stranded cDNAs. Ko MS. Nucleic Acids Res, 1990 Oct 11. PMID 2216762, Free PMC Article
    5. The AAA-ATPase ATAD1 and its partners promote degradation of desmin intermediate filaments in muscle. Aweida D, et al. EMBO Rep, 2022 Dec 6. PMID 36278411, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC6696

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables K48-linked polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables K48-linked polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables K6-linked polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables proteasome regulatory particle binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein K48-linked deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of protein K48-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of ubiquitin-specific protease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of VCP-NPL4-UFD1 AAA ATPase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    UBX domain-containing protein 1
    Names
    SAPK substrate protein 1
    UBA/UBX 33.3 kDa protein
    protein 2B28

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362044.1 → NP_001348973.1  UBX domain-containing protein 1

      Status: VALIDATED

      Source sequence(s)
      AK150442, BY238872, BY606648, CX123666
      Consensus CDS
      CCDS29553.1
      UniProtKB/Swiss-Prot
      Q3UCP8, Q922Y1
      UniProtKB/TrEMBL
      A0A498WFS2
      Related
      ENSMUSP00000157971.2, ENSMUST00000238036.2
      Conserved Domains (2) summary
      cd01772
      Location:210 → 293
      SAKS1_UBX; SAKS1-like UBX domain
      cd14302
      Location:5 → 45
      UBA_UBXN1; UBA domain found in UBX domain-containing protein 1 (UBXN1) and similar proteins

    2. NM_146093.2 → NP_666205.1  UBX domain-containing protein 1

      See identical proteins and their annotated locations for NP_666205.1

      Status: VALIDATED

      Source sequence(s)
      AC129217
      Consensus CDS
      CCDS29553.1
      UniProtKB/Swiss-Prot
      Q3UCP8, Q922Y1
      UniProtKB/TrEMBL
      A0A498WFS2
      Related
      ENSMUSP00000133250.2, ENSMUST00000166407.9
      Conserved Domains (2) summary
      cd01772
      Location:210 → 293
      SAKS1_UBX; SAKS1-like UBX domain
      cd14302
      Location:5 → 45
      UBA_UBXN1; UBA domain found in UBX domain-containing protein 1 (UBXN1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      8848912..8853030
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q922Y1.1 GenPept UniProtKB/Swiss-Prot:Q922Y1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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