Tas1r3 taste receptor, type 1, member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tas1r3provided by MGI
Official Full Name: taste receptor, type 1, member 3provided by MGI
Primary source: MGI:MGI:1933547
See related: Ensembl:ENSMUSG00000029072 AllianceGenome:MGI:1933547
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sac; T1r3
Summary: Predicted to enable G protein-coupled receptor activity. Predicted to contribute to sweet taste receptor activity. Acts upstream of or within sensory perception of sweet taste. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of sweet taste receptor complex. Predicted to be integral component of plasma membrane. Is expressed in circumvallate papilla and tongue anterior part. Orthologous to human TAS1R3 (taste 1 receptor member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 1.6), thymus adult (RPKM 1.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 E2; 4 87.65 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (155943725..155947810, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (155859268..155863353, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Taste receptor type 1 member 3 mediates diet-induced cognitive impairment in mice.
Title: Taste receptor type 1 member 3 mediates diet-induced cognitive impairment in mice.
Taste receptor type 1 member 3 enables western diet-induced anxiety in mice.
Title: Taste receptor type 1 member 3 enables western diet-induced anxiety in mice.
Prediction of dynamic allostery for the transmembrane domain of the sweet taste receptor subunit, TAS1R3.
Title: Prediction of dynamic allostery for the transmembrane domain of the sweet taste receptor subunit, TAS1R3.
Current Progress in Understanding the Structure and Function of Sweet Taste Receptor.
Title: Current Progress in Understanding the Structure and Function of Sweet Taste Receptor.
Loss of the nutrient receptor Tas1R3 reduces atherosclerotic plaque accumulation and hepatic steatosis in ApoE(-/-) mice.
Title: Loss of the nutrient receptor Tas1R3 reduces atherosclerotic plaque accumulation and hepatic steatosis in ApoE(-/-) mice.
Allelic variation of the Tas1r3 taste receptor gene affects sweet taste responsiveness and metabolism of glucose in F1 mouse hybrids.
Title: Allelic variation of the Tas1r3 taste receptor gene affects sweet taste responsiveness and metabolism of glucose in F1 mouse hybrids.
TAS1R3 is not required to mount an immune response to the helminth Heligmosomoides polygyrus, which infects the proximal small intestine. Examination of uninfected Tas1r3(-/-) mice revealed a modest reduction in the number of tuft cells in the proximal small intestine but a severe decrease in the distal small intestine at homeostasis.
Title: The Taste Receptor TAS1R3 Regulates Small Intestinal Tuft Cell Homeostasis.
this study shows that taste receptor T1R3 promotes the tumoricidal activity of hepatic CD49a(+) CD49b(-) natural killer cells
Title: Taste receptor T1R1/T1R3 promotes the tumoricidal activity of hepatic CD49a(+) CD49b(-) natural killer cells.
residual sensitivity by the T1R1+T1R3 KO mice demonstrates that a T1R-independent mechanism can contribute to the detectability of high concentrations of this prototypical umami compound stimulus
Title: Taste sensitivity to a mixture of monosodium glutamate and inosine 5'-monophosphate by mice lacking both subunits of the T1R1+T1R3 amino acid receptor.
Data suggest that Tas1r2 and Tas1r3 are involved in regulation of Glp1 secretion in enteroendocrine cells; 3DG (3-deoxyglucosone) attenuates high glucose-stimulated Glp1 secretion by antagonizing Tas1r2/Tas1r3 subunits and downstream cAMP signaling. (Tas1r2 = sweet taste receptor subunit Tas1r2; Tas1r3 = sweet taste receptor subunit Tas1r3; Glp1 = glucagon-like peptide-1)
Title: The downregulation of sweet taste receptor signaling in enteroendocrine L-cells mediates 3-deoxyglucosone-induced attenuation of high glucose-stimulated GLP-1 secretion.

Submit: New GeneRIF Correction See all GeneRIFs (68)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Not Applicable (2) 1 citation
Targeted (4) 1 citation

General gene information

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Markers

Dvl (e-PCR), detects polymorphism
- UniSTS:142878

D4Mon6 (e-PCR)
- UniSTS:241015

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to sweet taste receptor activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to sweet taste receptor activity	ISO Inferred from Sequence Orthology more info
contributes_to taste receptor activity	ISO Inferred from Sequence Orthology more info
enables taste receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in detection of chemical stimulus involved in sensory perception of sweet taste	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to stimulus	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of sweet taste	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sensory perception of sweet taste	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sensory perception of sweet taste	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception of taste	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of umami taste	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of umami taste	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed
part_of sweet taste receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: taste receptor type 1 member 3

Names: saccharin preference protein; sweet taste receptor T1R3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031872.2 → NP_114078.1 taste receptor type 1 member 3 precursor

See identical proteins and their annotated locations for NP_114078.1

Status: PROVISIONAL

Source sequence(s)

AL670236

Consensus CDS

CCDS19046.1

UniProtKB/Swiss-Prot

A2ADA0, Q91VA4, Q923K0, Q925A4, Q925D8, Q925D9

Related

ENSMUSP00000030949.4, ENSMUST00000030949.4

Conserved Domains (4) summary

pfam00003
Location:597 → 821

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

pfam01094
Location:73 → 469

ANF_receptor; Receptor family ligand binding region

pfam07562
Location:501 → 551

NCD3G; Nine Cysteines Domain of family 3 GPCR

cl10011
Location:29 → 494

Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily