Zfy1 zinc finger protein 1, Y-linked [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfy1provided by MGI
Official Full Name: zinc finger protein 1, Y-linkedprovided by MGI
Primary source: MGI:MGI:99212
See related: Ensembl:ENSMUSG00000053211 AllianceGenome:MGI:99212
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Zfy2; Zfy-1
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in nucleus. Is expressed in genitourinary system; heart; liver; lung; and trunk. Orthologous to human ZFY (zinc finger protein Y-linked). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: Y; Ypter

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	Y	NC_000087.8 (725207..797409, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	Y	NC_000087.7 (725207..797409, complement)

Chromosome Y - NC_000087.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of mouse Y chromosome gene Zfy1 and Zfy2 leads to spermatogenesis impairment, sperm defects, and infertility.
Title: Loss of mouse Y chromosome gene Zfy1 and Zfy2 leads to spermatogenesis impairment, sperm defects, and infertility.
our findings show that RNAi-mediated disruption of Zfx/Zfy in mouse testis affected X/Y spermatogenesis. Additionally, results suggest that the paralogous genes Zfx/Zfy play an important role in the process of X and Y sperm development. The individual interference of Zfx/Zfy may predict the outcome of X and Y haploid sperms. Presented herein is an advanced method developed to control mouse X/Y spermatogenesis and sex rati
Title: RNAi as a tool to control the sex ratio of mouse offspring by interrupting Zfx/Zfy genes in the testis.
we show that in mice, Zfy genes(Zfy1 and Zfy2 ) are also necessary for efficient meiotic sex chrand the sex chromosomes are not correctly silenced in Zfy-deficient spermatocytes.
Title: Zfy genes are required for efficient meiotic sex chromosome inactivation (MSCI) in spermatocytes.
Zfy1-KO mice did not show any significant phenotypic alterations. Zfy1/2-DKO mice were infertile and displayed abnormal sperm morphology and fertilization failure.
Title: Complementary Critical Functions of Zfy1 and Zfy2 in Mouse Spermatogenesis and Reproduction.
genetic information on the short arm of the Y chromosome promotes meiosis II, and by transgene addition Zfy1 and Zfy2 were identified as the genes responsible.
Title: Mouse Y-linked Zfy1 and Zfy2 are expressed during the male-specific interphase between meiosis I and meiosis II and promote the 2nd meiotic division.
Studies identified a Zfy2 transcript that predominates in spermatids, and a Zfy1 transcript, lacking an exon encoding approximately half of the acidic domain.
Title: Human and mouse ZFY genes produce a conserved testis-specific transcript encoding a zinc finger protein with a short acidic domain and modified transactivation potential.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation

General gene information

Go to the top of the page Help

Markers

Zfy1 (e-PCR), detects polymorphism
- UniSTS:226079

Zfy1 (e-PCR), detects polymorphism
- UniSTS:256879

Zfy1 (e-PCR), detects polymorphism
- UniSTS:466051

Zfy1 (e-PCR), detects polymorphism
- UniSTS:256416

PMC262401P1 (e-PCR)
- UniSTS:272312

Zfy1 (e-PCR), detects polymorphism
- UniSTS:144834

Zfy1 (e-PCR), detects polymorphism
- UniSTS:144835

Zfy1 (e-PCR), detects polymorphism
- UniSTS:144836

Zfy1 (e-PCR), detects polymorphism
- UniSTS:144837

Zfy2 (e-PCR), detects polymorphism
- UniSTS:144838

PMC136376P1 (e-PCR)
- UniSTS:270797

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: zinc finger Y-chromosomal protein 1

Names: Y-linked zinc finger protein 1; Y-linked zinc finger protein 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009570.4 → NP_033596.3 zinc finger Y-chromosomal protein 1

See identical proteins and their annotated locations for NP_033596.3

Status: VALIDATED

Source sequence(s)

AK076618, X14382

Consensus CDS

CCDS30539.1

UniProtKB/Swiss-Prot

E9QKM5, P10925, Q8C638

Related

ENSMUSP00000069364.5, ENSMUST00000065545.6

Conserved Domains (6) summary

COG5048
Location:513 → 687

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:528 → 548

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00019
Location:405 → 425

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:526 → 548

zf-C2H2; Zinc finger, C2H2 type

pfam04704
Location:68 → 388

Zfx_Zfy_act; Zfx / Zfy transcription activation region

pfam13465
Location:540 → 562

zf-H2C2_2; Zinc-finger double domain