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    Dnai7 dynein axonemal intermediate chain 7 [ Mus musculus (house mouse) ]

    Gene ID: 320662, updated on 8-May-2024

    Summary

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    Official Symbol
    Dnai7provided by MGI
    Official Full Name
    dynein axonemal intermediate chain 7provided by MGI
    Primary source
    MGI:MGI:2444480
    See related
    Ensembl:ENSMUSG00000043541 AllianceGenome:MGI:2444480
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Las1; Casc1; Cfap94; A230084G12Rik
    Summary
    Enables beta-tubulin binding activity and microtubule binding activity. Predicted to act upstream of or within microtubule sliding. Located in cilium; cytoplasm; and microtubule cytoskeleton. Part of axonemal dynein complex. Orthologous to human DNAI7 (dynein axonemal intermediate chain 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 5.2), spleen adult (RPKM 4.7) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dnai7 in Genome Data Viewer
    Location:
    6 G3; 6 77.37 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (145120556..145156866, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (145174833..145211017, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene branched chain aminotransferase 1, cytosolic Neighboring gene predicted gene, 26666 Neighboring gene STARR-seq mESC enhancer starr_17771 Neighboring gene STARR-positive B cell enhancer ABC_E11339 Neighboring gene STARR-seq mESC enhancer starr_17772 Neighboring gene predicted gene, 38925 Neighboring gene STARR-positive B cell enhancer ABC_E8147 Neighboring gene STARR-seq mESC enhancer starr_17775 Neighboring gene STARR-seq mESC enhancer starr_17776 Neighboring gene STARR-positive B cell enhancer ABC_E2809 Neighboring gene STARR-positive B cell enhancer mm9_chr6:145072197-145072498 Neighboring gene inositol 1,4,5-triphosphate receptor associated 2 Neighboring gene STARR-positive B cell enhancer ABC_E4880 Neighboring gene predicted gene 15543 Neighboring gene STARR-seq mESC enhancer starr_17780 Neighboring gene electron transfer flavoprotein regulatory factor 1 Neighboring gene Kirsten rat sarcoma viral oncogene homolog Neighboring gene predicted gene 15706 Neighboring gene ribosomal protein S25, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. IC97 is a novel intermediate chain of I1 dynein that interacts with tubulin and regulates interdoublet sliding. Wirschell M, et al. Mol Biol Cell, 2009 Jul. PMID 19420136, Free PMC Article
    2. Degradation of lung adenoma susceptibility 1, a major candidate mouse lung tumor modifier, is required for cell cycle progression. Liu Y, et al. Cancer Res, 2007 Nov 1. PMID 17974961
    3. Allelic effects of mouse Pas1 candidate genes in human lung cancer cell lines. Galbiati F, et al. Cancer Lett, 2006 Dec 8. PMID 16458428
    4. A quantitative trait locus on chromosome 6 regulates the onset of puberty in mice. Nathan BM, et al. Endocrinology, 2006 Nov. PMID 16873534
    5. Positional cloning of the major quantitative trait locus underlying lung tumor susceptibility in mice. Zhang Z, et al. Proc Natl Acad Sci U S A, 2003 Oct 28. PMID 14583591, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The differential degradation of Las1-A/J and Las-B6 produced from the 2 corresponding alleles, has important implications for its intracellular function and may eventually explain Las1-A/J in lung tumorigenesis.
      Title: Degradation of lung adenoma susceptibility 1, a major candidate mouse lung tumor modifier, is required for cell cycle progression.
    2. Las1 is part of the complex multigenic Pas1 locus, with a functional role for its intragenic polymorphisms and AA changes in lung tumor susceptibility. It may be a tumor suppressor.
      Title: Haplotype sharing suggests that a genomic segment containing six genes accounts for the pulmonary adenoma susceptibility 1 (Pas1) locus activity in mice.
    3. Casc1 knockout mouse tumor bioassays showed that Casc1-deficient mice were susceptible to chemical induction of lung tumors.
      Title: Candidate lung tumor susceptibility genes identified through whole-genome association analyses in inbred mice.
    4. Whole-genome association analyis of lung tumor susceptibility refined the Pas1 locus to a region of less than 0.5 Mb containing two strong candidates, Kras2 and Casc1 (also known as Las1).
      Title: Candidate lung tumor susceptibility genes identified through whole-genome association analyses in inbred mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables beta-tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-tubulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables beta-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within microtubule sliding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of axonemal dynein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasmic microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of inner dynein arm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dynein axonemal intermediate chain 7
    Names
    cancer susceptibility candidate 1
    cancer susceptibility candidate gene 1 protein homolog
    cancer susceptibility candidate protein 1
    cilia and flagella associated protein 94
    dynein intermediate chain CFAP94, axonemal
    lung adenoma susceptibility 1
    lung adenoma susceptibility protein 1
    protein CASC1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177222.4 → NP_796196.3  dynein axonemal intermediate chain 7

      See identical proteins and their annotated locations for NP_796196.3

      Status: VALIDATED

      Source sequence(s)
      AY485608, BB374869, CJ202396
      Consensus CDS
      CCDS39705.1
      UniProtKB/Swiss-Prot
      Q3V0T6, Q64JA2, Q675B4, Q675B5, Q6TDU8, Q8BZM3
      UniProtKB/TrEMBL
      A0A0R4J0S9
      Related
      ENSMUSP00000062279.8, ENSMUST00000060797.10
      Conserved Domains (2) summary
      pfam12366
      Location:244 → 469
      Casc1; Cancer susceptibility candidate 1
      pfam15927
      Location:39 → 229
      Casc1_N; Cancer susceptibility candidate 1 N-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      145120556..145156866 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506971.3 → XP_006507034.1  dynein axonemal intermediate chain 7 isoform X5

      UniProtKB/Swiss-Prot
      Q3V0T6, Q64JA2, Q675B4, Q675B5, Q6TDU8, Q8BZM3
      Conserved Domains (1) summary
      pfam15927
      Location:39 → 183
      Casc1_N; Cancer susceptibility candidate 1 N-terminus

    2. XM_017321645.2 → XP_017177134.1  dynein axonemal intermediate chain 7 isoform X10

      Conserved Domains (2) summary
      pfam12366
      Location:336 → 483
      Casc1; Cancer susceptibility candidate 1
      pfam15927
      Location:39 → 205
      Casc1_N; Cancer susceptibility candidate 1 N-terminus

    3. XM_011241588.2 → XP_011239890.1  dynein axonemal intermediate chain 7 isoform X1

      UniProtKB/Swiss-Prot
      Q3V0T6, Q64JA2, Q675B4, Q675B5, Q6TDU8, Q8BZM3
      Conserved Domains (1) summary
      pfam15927
      Location:39 → 218
      Casc1_N; Cancer susceptibility candidate 1 N-terminus

    4. XM_006506974.3 → XP_006507037.1  dynein axonemal intermediate chain 7 isoform X8

      UniProtKB/Swiss-Prot
      Q3V0T6, Q64JA2, Q675B4, Q675B5, Q6TDU8, Q8BZM3
      Conserved Domains (2) summary
      pfam12366
      Location:377 → 524
      Casc1; Cancer susceptibility candidate 1
      pfam15927
      Location:39 → 229
      Casc1_N; Cancer susceptibility candidate 1 N-terminus

    5. XM_006506972.3 → XP_006507035.1  dynein axonemal intermediate chain 7 isoform X6

      UniProtKB/Swiss-Prot
      Q3V0T6, Q64JA2, Q675B4, Q675B5, Q6TDU8, Q8BZM3
      Conserved Domains (2) summary
      pfam12366
      Location:429 → 576
      Casc1; Cancer susceptibility candidate 1
      pfam15927
      Location:39 → 229
      Casc1_N; Cancer susceptibility candidate 1 N-terminus

    6. XM_011241593.2 → XP_011239895.1  dynein axonemal intermediate chain 7 isoform X4

      UniProtKB/Swiss-Prot
      Q3V0T6, Q64JA2, Q675B4, Q675B5, Q6TDU8, Q8BZM3
      Conserved Domains (2) summary
      pfam12366
      Location:440 → 587
      Casc1; Cancer susceptibility candidate 1
      pfam15927
      Location:39 → 229
      Casc1_N; Cancer susceptibility candidate 1 N-terminus

    7. XM_006506970.3 → XP_006507033.1  dynein axonemal intermediate chain 7 isoform X3

      UniProtKB/TrEMBL
      A0A0R4J1G3
      Related
      ENSMUSP00000107357.2, ENSMUST00000111728.8
      Conserved Domains (1) summary
      pfam15927
      Location:39 → 229
      Casc1_N; Cancer susceptibility candidate 1 N-terminus

    8. XM_006506973.3 → XP_006507036.1  dynein axonemal intermediate chain 7 isoform X7

      UniProtKB/Swiss-Prot
      Q3V0T6, Q64JA2, Q675B4, Q675B5, Q6TDU8, Q8BZM3
      Conserved Domains (2) summary
      pfam12366
      Location:391 → 538
      Casc1; Cancer susceptibility candidate 1
      pfam15927
      Location:6 → 137
      Casc1_N; Cancer susceptibility candidate 1 N-terminus

    9. XM_017321646.2 → XP_017177135.1  dynein axonemal intermediate chain 7 isoform X9

      UniProtKB/Swiss-Prot
      Q3V0T6, Q64JA2, Q675B4, Q675B5, Q6TDU8, Q8BZM3
      Conserved Domains (2) summary
      pfam12366
      Location:366 → 513
      Casc1; Cancer susceptibility candidate 1
      pfam15927
      Location:1 → 112
      Casc1_N; Cancer susceptibility candidate 1 N-terminus

    10. XM_011241590.1 → XP_011239892.1  dynein axonemal intermediate chain 7 isoform X2

      See identical proteins and their annotated locations for XP_011239892.1

      UniProtKB/Swiss-Prot
      Q3V0T6, Q64JA2, Q675B4, Q675B5, Q6TDU8, Q8BZM3
      Conserved Domains (1) summary
      pfam15927
      Location:26 → 216
      Casc1_N; Cancer susceptibility candidate 1 N-terminus

    11. XM_011241591.1 → XP_011239893.1  dynein axonemal intermediate chain 7 isoform X2

      See identical proteins and their annotated locations for XP_011239893.1

      UniProtKB/Swiss-Prot
      Q3V0T6, Q64JA2, Q675B4, Q675B5, Q6TDU8, Q8BZM3
      Conserved Domains (1) summary
      pfam15927
      Location:26 → 216
      Casc1_N; Cancer susceptibility candidate 1 N-terminus

    12. XM_011241592.1 → XP_011239894.1  dynein axonemal intermediate chain 7 isoform X2

      See identical proteins and their annotated locations for XP_011239894.1

      UniProtKB/Swiss-Prot
      Q3V0T6, Q64JA2, Q675B4, Q675B5, Q6TDU8, Q8BZM3
      Conserved Domains (1) summary
      pfam15927
      Location:26 → 216
      Casc1_N; Cancer susceptibility candidate 1 N-terminus

    13. XM_011241589.3 → XP_011239891.1  dynein axonemal intermediate chain 7 isoform X2

      See identical proteins and their annotated locations for XP_011239891.1

      UniProtKB/Swiss-Prot
      Q3V0T6, Q64JA2, Q675B4, Q675B5, Q6TDU8, Q8BZM3
      Conserved Domains (1) summary
      pfam15927
      Location:26 → 216
      Casc1_N; Cancer susceptibility candidate 1 N-terminus

    14. XM_036166231.1 → XP_036022124.1  dynein axonemal intermediate chain 7 isoform X9

      UniProtKB/Swiss-Prot
      Q3V0T6, Q64JA2, Q675B4, Q675B5, Q6TDU8, Q8BZM3
      Conserved Domains (2) summary
      pfam12366
      Location:366 → 513
      Casc1; Cancer susceptibility candidate 1
      pfam15927
      Location:1 → 112
      Casc1_N; Cancer susceptibility candidate 1 N-terminus

    15. XM_011241594.2 → XP_011239896.1  dynein axonemal intermediate chain 7 isoform X11

      Conserved Domains (1) summary
      pfam15927
      Location:39 → 229
      Casc1_N; Cancer susceptibility candidate 1 N-terminus

    16. XM_006506978.3 → XP_006507041.1  dynein axonemal intermediate chain 7 isoform X12

      Conserved Domains (1) summary
      pfam15927
      Location:39 → 229
      Casc1_N; Cancer susceptibility candidate 1 N-terminus

    17. XM_030255463.2 → XP_030111323.1  dynein axonemal intermediate chain 7 isoform X13

      Conserved Domains (1) summary
      pfam15927
      Location:26 → 216
      Casc1_N; Cancer susceptibility candidate 1 N-terminus

    RNA

    1. XR_001785141.3 RNA Sequence

      Related
      ENSMUST00000111727.8

    2. XR_001785140.2 RNA Sequence

    3. XR_378098.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6TDU8.1 GenPept UniProtKB/Swiss-Prot:Q6TDU8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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