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    Actbl2 actin, beta-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 238880, updated on 5-May-2024

    Summary

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    Official Symbol
    Actbl2provided by MGI
    Official Full Name
    actin, beta-like 2provided by MGI
    Primary source
    MGI:MGI:2444552
    See related
    Ensembl:ENSMUSG00000055194 AllianceGenome:MGI:2444552
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4732495G21Rik
    Summary
    Predicted to enable protein kinase binding activity. Predicted to be a structural constituent of postsynaptic actin cytoskeleton. Predicted to be involved in axonogenesis and cell motility. Located in synapse. Is active in glutamatergic synapse. Orthologous to human ACTBL2 (actin beta like 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human all
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    Genomic context

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    See Actbl2 in Genome Data Viewer
    Location:
    13 D2.2; 13 63.1 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (111391547..111394283)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (111255013..111257749)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene SCAN domain containing 3 pseudogene Neighboring gene RIKEN cDNA 3110015C05 gene Neighboring gene STARR-seq mESC enhancer starr_35651 Neighboring gene electron transfer flavoprotein subunit alpha, mitochondrial pseudogene Neighboring gene GC-rich promoter binding protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E2421 Neighboring gene STARR-positive B cell enhancer ABC_E1468

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Proteomic screening of glutamatergic mouse brain synaptosomes isolated by fluorescence activated sorting. Biesemann C, et al. EMBO J, 2014 Jan 13. PMID 24413018, Free PMC Article
    2. PRC1 and PRC2 are not required for targeting of H2A.Z to developmental genes in embryonic stem cells. Illingworth RS, et al. PLoS One, 2012. PMID 22496869, Free PMC Article
    3. Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin. Zhou X, et al. J Cell Biol, 2015 Sep 14. PMID 26370502, Free PMC Article
    4. Identification of atrogin-1-targeted proteins during the myostatin-induced skeletal muscle wasting. Lokireddy S, et al. Am J Physiol Cell Physiol, 2012 Sep 1. PMID 22673621
    5. WDFY4 is required for cross-presentation in response to viral and tumor antigens. Theisen DJ, et al. Science, 2018 Nov 9. PMID 30409884, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of postsynaptic actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    beta-actin-like protein 2
    Names
    kappa-actin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175497.3 → NP_780706.1  beta-actin-like protein 2

      See identical proteins and their annotated locations for NP_780706.1

      Status: PROVISIONAL

      Source sequence(s)
      AK029110
      Consensus CDS
      CCDS26768.1
      UniProtKB/Swiss-Prot
      Q8BFZ3
      UniProtKB/TrEMBL
      Q3U5R4, Q3UA89, Q3UAF7, Q3UGS0, Q61276
      Related
      ENSMUSP00000052086.4, ENSMUST00000054716.4
      Conserved Domains (2) summary
      smart00268
      Location:7 → 376
      ACTIN; Actin
      cl17037
      Location:1 → 376
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      111391547..111394283
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BFZ3.1 GenPept UniProtKB/Swiss-Prot:Q8BFZ3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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