Tff1 trefoil factor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tff1provided by MGI
Official Full Name: trefoil factor 1provided by MGI
Primary source: MGI:MGI:88135
See related: Ensembl:ENSMUSG00000024032 AllianceGenome:MGI:88135
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PS2; Bcei
Summary: Predicted to enable growth factor activity. Acts upstream of or within cell differentiation and negative regulation of cell population proliferation. Predicted to be located in cytoplasm. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; ear; nervous system; reproductive system; and skeleton. Used to study stomach cancer. Orthologous to human TFF1 (trefoil factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward stomach adult (RPKM 12931.2) See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 15.8 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (31380369..31384034, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (31161395..31165060, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression Profiling along the Murine Intestine: Different Mucosal Protection Systems and Alterations in Tff1-Deficient Animals.
Title: Expression Profiling along the Murine Intestine: Different Mucosal Protection Systems and Alterations in Tff1-Deficient Animals.
Trefoil factor 1 inhibits the development of esophageal adenocarcinoma from Barrett's epithelium.
Title: Trefoil factor 1 inhibits the development of esophageal adenocarcinoma from Barrett's epithelium.
Aorta Regulatory T Cells with a Tissue-Specific Phenotype and Function Promote Tissue Repair through Tff1 in Abdominal Aortic Aneurysms.
Title: Aorta Regulatory T Cells with a Tissue-Specific Phenotype and Function Promote Tissue Repair through Tff1 in Abdominal Aortic Aneurysms.
Runx1 regulates Tff1 expression to expedite viability of retinal microvascular endothelial cells in mice with diabetic retinopathy.
Title: Runx1 regulates Tff1 expression to expedite viability of retinal microvascular endothelial cells in mice with diabetic retinopathy.
Premalignant pancreatic cells seed stealth metastasis in distant organs in mice.
Title: Premalignant pancreatic cells seed stealth metastasis in distant organs in mice.
Molecular Alterations in the Stomach of Tff1-Deficient Mice: Early Steps in Antral Carcinogenesis.
Title: Molecular Alterations in the Stomach of Tff1-Deficient Mice: Early Steps in Antral Carcinogenesis.
Study findings demonstrate a functional role of TFF1 in suppressing gastric tumorigenesis by impeding the IL6-STAT3 pro-inflammatory signaling axis.
Title: Activation of STAT3 signaling is mediated by TFF1 silencing in gastric neoplasia.
This study indicates that the acquisition of TFF1 expression is an early event in pancreatic carcinogenesis and that TFF1 might act as a tumor suppressor to prevent EMT and the invasive transformation of PanIN.
Title: Trefoil factor 1 inhibits epithelial-mesenchymal transition of pancreatic intraepithelial neoplasm.
TFF1 is responsible for liver regeneration after liver injury by promoting the differentiation of hepatic progenitor cells (HPC) into a biliary lineage and inhibiting HPC differentiation into a hepatic lineage.
Title: Loss of trefoil factor 1 inhibits biliary regeneration but accelerates the hepatic differentiation of progenitor cells in mice.
these data suggest that TFF1 might help cells to counteract Helicobacter colonization and the development of a chronic inflammation.
Title: Gastric TFF1 Expression from Acute to Chronic Helicobacter Infection.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation
Targeted (3) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:491283

Tff1 (e-PCR), detects polymorphism
- UniSTS:234019

Tff1 (e-PCR), detects polymorphism
- UniSTS:259154

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of gastrointestinal epithelium	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to wounding	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: trefoil factor 1

Names: protein pS2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009362.2 → NP_033388.1 trefoil factor 1 precursor

See identical proteins and their annotated locations for NP_033388.1

Status: VALIDATED

Source sequence(s)

AK131896

Consensus CDS

CCDS37546.1

UniProtKB/Swiss-Prot

Q08423, Q3TVE6

UniProtKB/TrEMBL

Q149Y8

Related

ENSMUSP00000024831.7, ENSMUST00000024831.8

Conserved Domains (1) summary

smart00018
Location:32 → 74

PD; P or trefoil or TFF domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

31380369..31384034 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006524030.3 → XP_006524093.1 trefoil factor 1 isoform X1

Conserved Domains (1) summary

smart00018
Location:32 → 74

PD; P or trefoil or TFF domain