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    Zbtb7c zinc finger and BTB domain containing 7C [ Mus musculus (house mouse) ]

    Gene ID: 207259, updated on 11-Jun-2024

    Summary

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    Official Symbol
    Zbtb7cprovided by MGI
    Official Full Name
    zinc finger and BTB domain containing 7Cprovided by MGI
    Primary source
    MGI:MGI:2443302
    See related
    Ensembl:ENSMUSG00000044646 AllianceGenome:MGI:2443302
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kr-pok; Zbtb36; B230208J24Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within positive regulation of fat cell differentiation; positive regulation of transcription by RNA polymerase II; and regulation of RNA polymerase II regulatory region sequence-specific DNA binding activity. Located in nucleus. Is expressed in central nervous system; craniocervical region bone; esophagus; maturing glomerular tuft; and nose. Orthologous to human ZBTB7C (zinc finger and BTB domain containing 7C). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in stomach adult (RPKM 11.5), colon adult (RPKM 6.0) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zbtb7c in Genome Data Viewer
    Location:
    18 E3; 18 51.1 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (75953249..76281635)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (75820178..76148564)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700034B16 gene Neighboring gene predicted gene, 33703 Neighboring gene STARR-seq mESC enhancer starr_45085 Neighboring gene STARR-seq mESC enhancer starr_45086 Neighboring gene predicted gene, 52362 Neighboring gene RIKEN cDNA 2900057B20 gene Neighboring gene STARR-seq mESC enhancer starr_45090 Neighboring gene predicted gene, 52361 Neighboring gene STARR-seq mESC enhancer starr_45092 Neighboring gene microRNA 6358 Neighboring gene predicted gene, 52360 Neighboring gene predicted gene 9028

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Derepression of matrix metalloproteinase gene transcription and an emphysema-like phenotype in transcription factor Zbtb7c knockout mouse lungs. Jeon BN, et al. FEBS Lett, 2019 Sep. PMID 31222731
    2. Zbtb7c is a critical gluconeogenic transcription factor that induces glucose-6-phosphatase and phosphoenylpyruvate carboxykinase 1 genes expression during mice fasting. Choi WI, et al. Biochim Biophys Acta Gene Regul Mech, 2019 Jun. PMID 30959128
    3. Proto-oncoprotein Zbtb7c and SIRT1 repression: implications in high-fat diet-induced and age-dependent obesity. Choi WI, et al. Exp Mol Med, 2021 May. PMID 34017061, Free PMC Article
    4. Retinoic acid regulation of eye and testis-specific transcripts within a complex locus. Das P, et al. Mech Dev, 2007 Feb. PMID 17166701, Free PMC Article
    5. The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment. He X, et al. Nature, 2005 Feb 24. PMID 15729333

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Proto-oncoprotein Zbtb7c and SIRT1 repression: implications in high-fat diet-induced and age-dependent obesity.
      Title: Proto-oncoprotein Zbtb7c and SIRT1 repression: implications in high-fat diet-induced and age-dependent obesity.
    2. Zbtb7c degradation or absence may contribute to the pathogenesis of emphysema
      Title: Derepression of matrix metalloproteinase gene transcription and an emphysema-like phenotype in transcription factor Zbtb7c knockout mouse lungs.
    3. Zbtb7c to be a crucial metabolic regulator of blood glucose homeostasis, during mammalian fasting.
      Title: Zbtb7c is a critical gluconeogenic transcription factor that induces glucose-6-phosphatase and phosphoenylpyruvate carboxykinase 1 genes expression during mice fasting.
    4. findings show that Zbtb7c is a key molecule that recruits an NCoR/Hdac3 complex to inhibit phosphorylation of c-Jun, and thereby repress Mmp gene expression
      Title: Zbtb7c is a molecular 'off' and 'on' switch of Mmp gene transcription.
    5. Kr-pok (kidney cancer-related POZ domain and Kruppel-like protein) activates transcription of the FASN gene.
      Title: Kr-pok increases FASN expression by modulating the DNA binding of SREBP-1c and Sp1 at the proximal promoter.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of RNA polymerase II regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 7C
    Names
    zinc finger and BTB domain containing 36
    zinc finger and BTB domain-containing protein 36

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357506.2 → NP_001344435.1  zinc finger and BTB domain-containing protein 7C

      Status: VALIDATED

      Source sequence(s)
      AC107768
      Consensus CDS
      CCDS29349.1
      UniProtKB/Swiss-Prot
      Q8VCZ7
      Related
      ENSMUSP00000126808.2, ENSMUST00000167921.2
      Conserved Domains (3) summary
      COG5189
      Location:380 → 468
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:394 → 414
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18328
      Location:9 → 128
      BTB_POZ_ZBTB7C_ZBTB36; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C)

    2. NM_145356.3 → NP_663331.1  zinc finger and BTB domain-containing protein 7C

      See identical proteins and their annotated locations for NP_663331.1

      Status: VALIDATED

      Source sequence(s)
      BC070424
      Consensus CDS
      CCDS29349.1
      UniProtKB/Swiss-Prot
      Q8VCZ7
      Related
      ENSMUSP00000057856.8, ENSMUST00000058997.15
      Conserved Domains (3) summary
      COG5189
      Location:380 → 468
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:394 → 414
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18328
      Location:9 → 128
      BTB_POZ_ZBTB7C_ZBTB36; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      75953249..76281635
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161041.1 → XP_036016934.1  zinc finger and BTB domain-containing protein 7C isoform X1

      Conserved Domains (3) summary
      COG5189
      Location:386 → 474
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:400 → 420
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18328
      Location:15 → 134
      BTB_POZ_ZBTB7C_ZBTB36; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C)

    2. XM_036161042.1 → XP_036016935.1  zinc finger and BTB domain-containing protein 7C isoform X2

      UniProtKB/Swiss-Prot
      Q8VCZ7
      Conserved Domains (3) summary
      COG5189
      Location:380 → 468
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:394 → 414
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18328
      Location:9 → 128
      BTB_POZ_ZBTB7C_ZBTB36; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VCZ7.1 GenPept UniProtKB/Swiss-Prot:Q8VCZ7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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