TRM112 RNA methylation protein TRM112 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: TRM112
Gene description: RNA methylation protein TRM112
Primary source: FungiDB:YNR046W
Locus tag: YNR046W
See related: SGD:S000005329; AllianceGenome:SGD:S000005329
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Contributes to protein methyltransferase activity; rRNA (guanine) methyltransferase activity; and tRNA (guanine-N2-)-methyltransferase activity. Involved in ncRNA processing and peptidyl-glutamine methylation. Located in cytoplasm and nucleolus. Part of eRF1 methyltransferase complex and tRNA (m2G10) methyltransferase complex. Orthologous to human TRMT112 (tRNA methyltransferase activator subunit 11-2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See TRM112 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (707788..708195)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The catalytic activity of the translation termination factor methyltransferase Mtq2-Trm112 complex is required for large ribosomal subunit biogenesis.
Title: The catalytic activity of the translation termination factor methyltransferase Mtq2-Trm112 complex is required for large ribosomal subunit biogenesis.
Trm112 is required for efficient ribosome synthesis and progression through mitosis
Title: Trm112 is required for Bud23-mediated methylation of the 18S rRNA at position G1575.
Trm112p is a 15-kDa zinc finger protein essential for the activity of two tRNA and one protein methyltransferases in yeast
Title: Trm112p is a 15-kDa zinc finger protein essential for the activity of two tRNA and one protein methyltransferases in yeast.
The Ynr046w eRF1 methyltransferase subunit is shared by the tRNA methyltransferase Trm11p and probably by two other enzymes containing a Rossman fold
Title: The zinc finger protein Ynr046w is plurifunctional and a component of the eRF1 methyltransferase in yeast.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in maturation of LSU-rRNA	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maturation of SSU-rRNA	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-glutamine methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-glutamine methylation	IDA Inferred from Direct Assay more info	PubMed
involved_in rRNA (guanine-N7)-methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA (guanine-N7)-methylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosomal large subunit biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosomal small subunit biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tRNA methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA methylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of eRF1 methyltransferase complex	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleolus	HDA more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of tRNA (m2G10) methyltransferase complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: RNA methylation protein TRM112

NP_014444.1

Protein involved in methylation of tRNA, rRNA, and translation factors; also involved in ribosome biogenesis; subunit of tRNA methyltransferase (MTase) complexes in combination with Trm9p and Trm11p; N7-methylates G1575 of 18S rRNA as complex with Bud23p; subunit of complex with Mtq2p that methylates Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; relative distribution to the nucleus increases upon DNA replication stress; functional homolog of human TRMT112

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

707788..708195

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183223.1 → NP_014444.1 TPA: RNA methylation protein TRM112 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014444.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W1M1, P53738

UniProtKB/TrEMBL

A0A6A5Q8J8, A6ZSC0, B3LPJ7, C7GLL1, C8ZFS5, G2WLA3, N1NZS7

Conserved Domains (1) summary

cd21089
Location:2 → 130

Trm112-like; eukaryotic tRNA methyltransferase 112, a partner protein of both rRNA/tRNA and protein methyltransferases, and similar proteins