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    Cdk15 cyclin dependent kinase 15 [ Mus musculus (house mouse) ]

    Gene ID: 271697, updated on 12-May-2024

    Summary

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    Official Symbol
    Cdk15provided by MGI
    Official Full Name
    cyclin dependent kinase 15provided by MGI
    Primary source
    MGI:MGI:3583944
    See related
    Ensembl:ENSMUSG00000026023 AllianceGenome:MGI:3583944
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pftk2; Als2cr7
    Summary
    Predicted to enable cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation and regulation of transcription involved in G1/S transition of mitotic cell cycle. Predicted to act upstream of or within phosphorylation. Predicted to be active in cytosol and nucleus. Orthologous to human CDK15 (cyclin dependent kinase 15). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Cdk15 in Genome Data Viewer
    Location:
    1 C1.3- C2; 1 29.47 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (59296029..59391656)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (59256861..59352497)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:59219938-59220121 Neighboring gene alsin Rho guanine nucleotide exchange factor Neighboring gene STARR-positive B cell enhancer ABC_E1993 Neighboring gene predicted gene, 33667 Neighboring gene STARR-seq mESC enhancer starr_01032 Neighboring gene VISTA enhancer mm1575 Neighboring gene VISTA enhancer mm489 Neighboring gene predicted gene, 51625 Neighboring gene STARR-seq mESC enhancer starr_01034 Neighboring gene predicted gene, 33724 Neighboring gene STARR-seq mESC enhancer starr_01037 Neighboring gene STARR-seq mESC enhancer starr_01039 Neighboring gene predicted gene, 33774

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-dependent kinase 15
    Names
    PFTAIRE protein kinase 2
    amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 7
    amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein homolog
    cell division protein kinase 15
    serine/threonine-protein kinase ALS2CR7
    serine/threonine-protein kinase PFTAIRE-2
    NP_001028545.2
    NP_001343318.1
    XP_006496111.1
    XP_006496112.1
    XP_011236833.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033373.3 → NP_001028545.2  cyclin-dependent kinase 15 isoform 1

      See identical proteins and their annotated locations for NP_001028545.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC116995, AC132361, AC153652
      Consensus CDS
      CCDS48273.1
      UniProtKB/Swiss-Prot
      B2RVR3, B7ZWG3, Q3V3A1
      UniProtKB/TrEMBL
      E3W997
      Related
      ENSMUSP00000109886.3, ENSMUST00000114248.3
      Conserved Domains (2) summary
      PLN00009
      Location:101 → 385
      PLN00009; cyclin-dependent kinase A; Provisional
      cd07870
      Location:100 → 385
      STKc_PFTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase

    2. NM_001356389.1 → NP_001343318.1  cyclin-dependent kinase 15 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC116995, AC132361, AC153652
      UniProtKB/TrEMBL
      E3W997
      Conserved Domains (1) summary
      cd07870
      Location:99 → 384
      STKc_PFTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      59296029..59391656
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496049.5 → XP_006496112.1  cyclin-dependent kinase 15 isoform X2

      UniProtKB/TrEMBL
      E3W997
      Conserved Domains (1) summary
      cl21453
      Location:99 → 399
      PKc_like; Protein Kinases, catalytic domain

    2. XM_006496048.5 → XP_006496111.1  cyclin-dependent kinase 15 isoform X1

      UniProtKB/TrEMBL
      E3W997
      Conserved Domains (1) summary
      cd07870
      Location:100 → 400
      STKc_PFTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase

    3. XM_011238531.3 → XP_011236833.1  cyclin-dependent kinase 15 isoform X3

      Conserved Domains (1) summary
      cl21453
      Location:10 → 214
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_373255.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3V3A1.2 GenPept UniProtKB/Swiss-Prot:Q3V3A1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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