Vdac2 voltage-dependent anion channel 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Vdac2provided by MGI
Official Full Name: voltage-dependent anion channel 2provided by MGI
Primary source: MGI:MGI:106915
See related: Ensembl:ENSMUSG00000021771 AllianceGenome:MGI:106915
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Vdac6; mVDAC2; mVDAC6
Summary: Predicted to enable several functions, including cholesterol binding activity; phosphatidylcholine binding activity; and voltage-gated anion channel activity. Involved in negative regulation of intrinsic apoptotic signaling pathway and negative regulation of protein polymerization. Located in mitochondrial inner membrane and myelin sheath. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human VDAC2 (voltage dependent anion channel 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 152.6), adrenal adult (RPKM 132.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 A3; 14 11.91 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (21881629..21895947)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (21831561..21845879)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SPATA33 is an autophagy mediator for cargo selectivity in germline mitophagy.
Title: SPATA33 is an autophagy mediator for cargo selectivity in germline mitophagy.
Cardiac-specific deletion of voltage dependent anion channel 2 leads to dilated cardiomyopathy by altering calcium homeostasis.
Title: Cardiac-specific deletion of voltage dependent anion channel 2 leads to dilated cardiomyopathy by altering calcium homeostasis.
VDAC2 phenocopied the loss of BAX in impairing both the killing of tumor cells by anti-cancer agents and the ability to suppress tumor formation.
Title: VDAC2 enables BAX to mediate apoptosis and limit tumor development.
an important MYBL2-VDAC2-BECN1-BCL2L1 pathway linking autophagy suppression in the developing ovary, is reported.
Title: MYBL2 guides autophagy suppressor VDAC2 in the developing ovary to inhibit autophagy through a complex of VDAC2-BECN1-BCL2L1 in mammals.
Motifs of VDAC2 required for mitochondrial Bak import and tBid-induced apoptosis.
Title: Motifs of VDAC2 required for mitochondrial Bak import and tBid-induced apoptosis.
Bax localizes to the mitochondrial outer membrane via alternate mechanisms, either constitutively via an interaction with VDAC2 or after activation via interaction with Bcl-2 family proteins.
Title: Bax targets mitochondria by distinct mechanisms before or during apoptotic cell death: a requirement for VDAC2 or Bak for efficient Bax apoptotic function.
Bcl-xL interacts functionally with VDAC1 and -3 but not VDAC2.
Title: An interaction between Bcl-xL and the voltage-dependent anion channel (VDAC) promotes mitochondrial Ca2+ uptake.
Abnormal regulation of VDACs negatively affected sperm function. Thus, VDACs may be key regulators of the fertilization ability of spermatozoa.
Title: Voltage-dependent anion channels are a key factor of male fertility.
VDAC2 acts as a crucial component in mitochondrial apoptosis by allowing the mitochondrial recruitment of BAK, thereby controlling tBID-induced OMM permeabilization and cell death.
Title: VDAC2 is required for truncated BID-induced mitochondrial apoptosis by recruiting BAK to the mitochondria.
Genetic depletion of Vdac2 in the thymus resulted in excessive cell death & hypersensitivity to diverse death stimuli including engagement of the T cell receptor. The VDAC2-BAK axis governs the homeostasis of thymocytes.
Title: The VDAC2-BAK rheostat controls thymocyte survival.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

U30838 (e-PCR)
- UniSTS:125719

AA900297 (e-PCR)
- UniSTS:248807

Vdac2 (e-PCR), detects polymorphism
- UniSTS:499191

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ceramide binding	ISO Inferred from Sequence Orthology more info
enables cholesterol binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables oxysterol binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphatidylcholine binding	ISO Inferred from Sequence Orthology more info
enables porin activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables voltage-gated monoatomic anion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated monoatomic anion channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in binding of sperm to zona pellucida	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial outer membrane permeabilization	ISO Inferred from Sequence Orthology more info
involved_in monoatomic anion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic anion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of intrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	HDA more info	PubMed
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial nucleoid	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in myelin sheath	HDA more info	PubMed
part_of pore complex	IEA Inferred from Electronic Annotation more info
located_in sperm midpiece	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: voltage-dependent anion-selective channel protein 2

Names: VDAC-2; VDAC-6; outer mitochondrial membrane protein porin 2; voltage-dependent anion-selective channel protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011695.2 → NP_035825.1 voltage-dependent anion-selective channel protein 2

See identical proteins and their annotated locations for NP_035825.1

Status: PROVISIONAL

Source sequence(s)

AC132590, AC151533

Consensus CDS

CCDS26867.1

UniProtKB/Swiss-Prot

Q60930, Q78MH6, Q99L98

UniProtKB/TrEMBL

G3UX26

Related

ENSMUSP00000022293.8, ENSMUST00000022293.14

Conserved Domains (1) summary

cd07306
Location:16 → 294

Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane