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    Zbtb8b zinc finger and BTB domain containing 8b [ Mus musculus (house mouse) ]

    Gene ID: 215627, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Zbtb8bprovided by MGI
    Official Full Name
    zinc finger and BTB domain containing 8bprovided by MGI
    Primary source
    MGI:MGI:2387181
    See related
    Ensembl:ENSMUSG00000048485 AllianceGenome:MGI:2387181
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BOZF1; Zbtb8
    Summary
    Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in early conceptus; eye; and genitourinary system. Orthologous to human ZBTB8B (zinc finger and BTB domain containing 8B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in ovary adult (RPKM 1.9), whole brain E14.5 (RPKM 1.2) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zbtb8b in Genome Data Viewer
    Location:
    4 D2.2; 4 63.26 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (129320063..129340761, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (129425765..129446969, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 8a Neighboring gene STARR-seq mESC enhancer starr_11489 Neighboring gene STARR-seq mESC enhancer starr_11490 Neighboring gene RIKEN cDNA C330020E22 gene Neighboring gene STARR-seq mESC enhancer starr_11493 Neighboring gene STARR-seq mESC enhancer starr_11495 Neighboring gene STARR-positive B cell enhancer ABC_E11256 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:129138525-129138708 Neighboring gene predicted gene, 24621 Neighboring gene BSD domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Medeiros de Araújo JA, et al. Development, 2021 Aug 15. PMID 34351428, Free PMC Article
    2. High-throughput mapping of a dynamic signaling network in mammalian cells. Barrios-Rodiles M, et al. Science, 2005 Mar 11. PMID 15761153
    3. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC38362

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 8B
    Names
    zinc finger and BTB domain containing 8

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153541.4 → NP_705769.2  zinc finger and BTB domain-containing protein 8B

      See identical proteins and their annotated locations for NP_705769.2

      Status: VALIDATED

      Source sequence(s)
      AL606921
      Consensus CDS
      CCDS18691.1
      UniProtKB/Swiss-Prot
      Q3US18, Q8CII0
      UniProtKB/TrEMBL
      A0A0R4J0Q8
      Related
      ENSMUSP00000058157.6, ENSMUST00000053042.6
      Conserved Domains (4) summary
      smart00225
      Location:25 → 122
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:333 → 353
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:14 → 118
      BTB; BTB/POZ domain
      pfam13465
      Location:346 → 370
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      129320063..129340761 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240481.4 → XP_011238783.1  zinc finger and BTB domain-containing protein 8B isoform X1

      See identical proteins and their annotated locations for XP_011238783.1

      UniProtKB/Swiss-Prot
      Q3US18, Q8CII0
      UniProtKB/TrEMBL
      I7HLR7
      Conserved Domains (4) summary
      sd00017
      Location:366 → 386
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18330
      Location:39 → 151
      BTB_POZ_ZBTB8B; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B)
      pfam13465
      Location:379 → 403
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:364 → 388
      zf-H2C2_5; C2H2-type zinc-finger domain

    2. XM_017320102.3 → XP_017175591.1  zinc finger and BTB domain-containing protein 8B isoform X1

      UniProtKB/Swiss-Prot
      Q3US18, Q8CII0
      UniProtKB/TrEMBL
      I7HLR7
      Conserved Domains (4) summary
      sd00017
      Location:366 → 386
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18330
      Location:39 → 151
      BTB_POZ_ZBTB8B; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B)
      pfam13465
      Location:379 → 403
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:364 → 388
      zf-H2C2_5; C2H2-type zinc-finger domain

    3. XM_036163954.1 → XP_036019847.1  zinc finger and BTB domain-containing protein 8B isoform X1

      UniProtKB/Swiss-Prot
      Q3US18, Q8CII0
      UniProtKB/TrEMBL
      I7HLR7
      Related
      ENSMUSP00000101661.2, ENSMUST00000106046.8
      Conserved Domains (4) summary
      sd00017
      Location:366 → 386
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18330
      Location:39 → 151
      BTB_POZ_ZBTB8B; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B)
      pfam13465
      Location:379 → 403
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:364 → 388
      zf-H2C2_5; C2H2-type zinc-finger domain

    4. XM_006502927.4 → XP_006502990.1  zinc finger and BTB domain-containing protein 8B isoform X1

      See identical proteins and their annotated locations for XP_006502990.1

      UniProtKB/Swiss-Prot
      Q3US18, Q8CII0
      UniProtKB/TrEMBL
      I7HLR7
      Conserved Domains (4) summary
      sd00017
      Location:366 → 386
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18330
      Location:39 → 151
      BTB_POZ_ZBTB8B; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B)
      pfam13465
      Location:379 → 403
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:364 → 388
      zf-H2C2_5; C2H2-type zinc-finger domain

    5. XM_017320101.2 → XP_017175590.1  zinc finger and BTB domain-containing protein 8B isoform X1

      UniProtKB/Swiss-Prot
      Q3US18, Q8CII0
      UniProtKB/TrEMBL
      I7HLR7
      Conserved Domains (4) summary
      sd00017
      Location:366 → 386
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18330
      Location:39 → 151
      BTB_POZ_ZBTB8B; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B)
      pfam13465
      Location:379 → 403
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:364 → 388
      zf-H2C2_5; C2H2-type zinc-finger domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CII0.1 GenPept UniProtKB/Swiss-Prot:Q8CII0

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