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    Romo1 reactive oxygen species modulator 1 [ Mus musculus (house mouse) ]

    Gene ID: 67067, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Romo1provided by MGI
    Official Full Name
    reactive oxygen species modulator 1provided by MGI
    Primary source
    MGI:MGI:1914317
    See related
    Ensembl:ENSMUSG00000067847 AllianceGenome:MGI:1914317
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2010100O12Rik
    Summary
    Predicted to be involved in several processes, including defense response to other organism; protein targeting to mitochondrion; and replicative senescence. Located in mitochondrion. Orthologous to human ROMO1 (reactive oxygen species modulator 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 102.7), adrenal adult (RPKM 88.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Romo1 in Genome Data Viewer
    Location:
    2 H1; 2 77.36 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (155986073..155987714)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (156144153..156145794)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene sperm associated antigen 4 Neighboring gene copine I Neighboring gene STARR-seq mESC enhancer starr_06153 Neighboring gene STARR-positive B cell enhancer ABC_E3414 Neighboring gene RNA binding motif protein 12 Neighboring gene nitrogen fixation gene 1 (S. cerevisiae) Neighboring gene RNA binding motif protein 39 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:156005117-156005304 Neighboring gene STARR-positive B cell enhancer ABC_E817 Neighboring gene STARR-seq mESC enhancer starr_06156 Neighboring gene STARR-positive B cell enhancer ABC_E9537 Neighboring gene STARR-seq mESC enhancer starr_06157 Neighboring gene PHD finger protein 20 Neighboring gene STARR-seq mESC enhancer starr_06159 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:156104477-156104678 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:156113998-156114107

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel protein, Romo1, induces ROS production in the mitochondria. Chung YM, et al. Biochem Biophys Res Commun, 2006 Sep 1. PMID 16842742
    2. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables monoatomic cation transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to reactive oxygen species ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytolysis by host of symbiont cells ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to Gram-negative bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in killing of cells of another organism ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monoatomic cation transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein import into mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein insertion into mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein insertion into mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in replicative senescence ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of TIM23 mitochondrial import inner membrane translocase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TIM23 mitochondrial import inner membrane translocase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    reactive oxygen species modulator 1
    Names
    ROS modulator 1
    protein MGR2 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164216.1 → NP_001157688.1  reactive oxygen species modulator 1

      See identical proteins and their annotated locations for NP_001157688.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AA058111, AK008300, BE996606
      Consensus CDS
      CCDS38296.1
      UniProtKB/Swiss-Prot
      A2BHV9, P60603
      Related
      ENSMUSP00000085981.5, ENSMUST00000088610.11
      Conserved Domains (1) summary
      pfam10247
      Location:14 → 79
      Romo1; Reactive mitochondrial oxygen species modulator 1

    2. NM_001164217.2 → NP_001157689.1  reactive oxygen species modulator 1

      See identical proteins and their annotated locations for NP_001157689.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AA058111, BC028749, CJ221444
      Consensus CDS
      CCDS38296.1
      UniProtKB/Swiss-Prot
      A2BHV9, P60603
      Related
      ENSMUSP00000113943.2, ENSMUST00000119950.2
      Conserved Domains (1) summary
      pfam10247
      Location:14 → 79
      Romo1; Reactive mitochondrial oxygen species modulator 1

    3. NM_025946.6 → NP_080222.1  reactive oxygen species modulator 1

      See identical proteins and their annotated locations for NP_080222.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      BC028749, EL963857
      Consensus CDS
      CCDS38296.1
      UniProtKB/Swiss-Prot
      A2BHV9, P60603
      Related
      ENSMUSP00000105226.4, ENSMUST00000109597.10
      Conserved Domains (1) summary
      pfam10247
      Location:14 → 79
      Romo1; Reactive mitochondrial oxygen species modulator 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      155986073..155987714
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P60603.1 GenPept UniProtKB/Swiss-Prot:P60603

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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