Acp5 acid phosphatase 5, tartrate resistant [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Acp5provided by MGI
Official Full Name: acid phosphatase 5, tartrate resistantprovided by MGI
Primary source: MGI:MGI:87883
See related: Ensembl:ENSMUSG00000001348 AllianceGenome:MGI:87883
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TRAP; TRACP
Summary: Enables acid phosphatase activity. Acts upstream of or within several processes, including bone resorption; negative regulation of cytokine production; and response to bacterium. Located in lysosome. Is expressed in several structures, including alimentary system; limb; liver; skeleton; and skin. Orthologous to human ACP5 (acid phosphatase 5, tartrate resistant). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in subcutaneous fat pad adult (RPKM 123.7), colon adult (RPKM 116.7) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A3; 9 8.38 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (22038023..22047042, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (22126727..22135746, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tartrate resistant acid phosphatase 5 (TRAP5) mediates immune cell recruitment in a murine model of pulmonary bacterial infection.
Title: Tartrate resistant acid phosphatase 5 (TRAP5) mediates immune cell recruitment in a murine model of pulmonary bacterial infection.
TRAP and nidogen-2 co-localized in adipose tissue cells in situ.
Title: The growth factor-like adipokine tartrate-resistant acid phosphatase 5a interacts with the rod G3 domain of adipocyte-produced nidogen-2.
Uteroferrin is a cytokine secreted by uterine glands in response to progesterone that promotes fetal erythropoiesis at various stages of pregnancy.
Title: Pregnancy-secreted Acid phosphatase, uteroferrin, enhances fetal erythropoiesis.
Supraphysiologic oscillatory fluid shear induces upregulation of osteoclastic activity, measured by tartrate-resistant acid phosphatase activity and formation of mineral resorption pits.
Title: A novel in vitro loading system to produce supraphysiologic oscillatory fluid shear stress.
Pax6 binds endogenously to the proximal region of the tartrate acid phosphatase (TRAP) gene promoter and suppresses nuclear factor of activated T cells c1 (NFATc1)-induced TRAP gene expression.
Title: The paired-box homeodomain transcription factor Pax6 binds to the upstream region of the TRAP gene promoter and suppresses receptor activator of NF-κB ligand (RANKL)-induced osteoclast differentiation.
Serum TRAP levels were lower in mice receiving eggshell calcium citrate malate than those receiving eggshells calcium malate.
Title: Assessment the levels of tartrate-resistant acid phosphatase (TRAP) on mice fed with eggshell calcium citrate malate.
tartrate resistant acid phosphatase
Title: Foreign body giant cells and osteoclasts are TRAP positive, have podosome-belts and both require OC-STAMP for cell fusion.
TRAP is not essential for the formation of the epiphyseal vascular network.
Title: Role of tartrate-resistant acid phosphatase (TRAP) in long bone development.
dephosphorylation of Man6P-containing lysosomal proteins requires the concerted action of Acp2 and Acp5 and is needed for hydrolysis and removal of degradation products
Title: Mannose 6 dephosphorylation of lysosomal proteins mediated by acid phosphatases Acp2 and Acp5.
in the absence of RANKL and osteoclast differentiation, STAT6 binds the TRAP promoter after IL-4 treatment and directly enhances TRAP expression
Title: Complex regulation of tartrate-resistant acid phosphatase (TRAP) expression by interleukin 4 (IL-4): IL-4 indirectly suppresses receptor activator of NF-kappaB ligand (RANKL)-mediated TRAP expression but modestly induces its expression directly.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Gene trapped (1)
Targeted (1) 1 citation

General gene information

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Markers

Acp5 (e-PCR), detects polymorphism
- UniSTS:498457

ACP5 (e-PCR)
- UniSTS:261992

M99054 (e-PCR)
- UniSTS:163454

D9Mit83 (e-PCR), detects polymorphism
- UniSTS:131969

Acp5 (e-PCR), detects polymorphism
- UniSTS:498362

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acid phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acid phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables acid phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables acid phosphatase activity	ISO Inferred from Sequence Orthology more info
enables ferric iron binding	IBA Inferred from Biological aspect of Ancestor more info
enables ferric iron binding	ISO Inferred from Sequence Orthology more info
enables ferrous iron binding	IBA Inferred from Biological aspect of Ancestor more info
enables ferrous iron binding	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within bone morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bone resorption	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within bone resorption	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of interleukin-1 beta production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of interleukin-12 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of macrophage cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of interleukin-1 beta production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of interleukin-12 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of macrophage cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of nitric oxide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of superoxide anion generation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of nitric oxide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to cytokine	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of superoxide anion generation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: tartrate-resistant acid phosphatase type 5

Names: TR-AP; acid phosphatase type V; tartrate-resistant acid ATPase; trATPase; type 5 acid phosphatase

NP_001095874.1

EC 3.1.3.2

NP_001095875.1

EC 3.1.3.2

NP_031414.1

EC 3.1.3.2

XP_006510007.1

EC 3.1.3.2

XP_006510008.1

EC 3.1.3.2

XP_006510009.1

EC 3.1.3.2

XP_011240686.1

EC 3.1.3.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001102404.1 → NP_001095874.1 tartrate-resistant acid phosphatase type 5 precursor

See identical proteins and their annotated locations for NP_001095874.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same isoform.

Source sequence(s)

AK010865, AK011915, BQ031772, BY084869

Consensus CDS

CCDS22923.1

UniProtKB/Swiss-Prot

Q05117

Related

ENSMUSP00000065425.7, ENSMUST00000069330.14

Conserved Domains (1) summary

cd07378
Location:28 → 313

MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
NM_001102405.1 → NP_001095875.1 tartrate-resistant acid phosphatase type 5 precursor

See identical proteins and their annotated locations for NP_001095875.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same isoform.

Source sequence(s)

AK010865, AK011915, BQ031772, BY107232

Consensus CDS

CCDS22923.1

UniProtKB/Swiss-Prot

Q05117

Related

ENSMUSP00000127128.2, ENSMUST00000165735.9

Conserved Domains (1) summary

cd07378
Location:28 → 313

MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
NM_007388.3 → NP_031414.1 tartrate-resistant acid phosphatase type 5 precursor

See identical proteins and their annotated locations for NP_031414.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same isoform.

Source sequence(s)

AK010865, AK011915, BG076865, BQ031772

Consensus CDS

CCDS22923.1

UniProtKB/Swiss-Prot

Q05117

Related

ENSMUSP00000110970.3, ENSMUST00000115315.3

Conserved Domains (1) summary

cd07378
Location:28 → 313

MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

22038023..22047042 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011242384.2 → XP_011240686.1 tartrate-resistant acid phosphatase type 5 isoform X1

See identical proteins and their annotated locations for XP_011240686.1

UniProtKB/Swiss-Prot

Q05117

Conserved Domains (1) summary

cd07378
Location:28 → 313

MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
XM_006509944.3 → XP_006510007.1 tartrate-resistant acid phosphatase type 5 isoform X1

See identical proteins and their annotated locations for XP_006510007.1

UniProtKB/Swiss-Prot

Q05117

Conserved Domains (1) summary

cd07378
Location:28 → 313

MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
XM_006509945.3 → XP_006510008.1 tartrate-resistant acid phosphatase type 5 isoform X1

See identical proteins and their annotated locations for XP_006510008.1

UniProtKB/Swiss-Prot

Q05117

Conserved Domains (1) summary

cd07378
Location:28 → 313

MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
XM_006509946.3 → XP_006510009.1 tartrate-resistant acid phosphatase type 5 isoform X1

See identical proteins and their annotated locations for XP_006510009.1

UniProtKB/Swiss-Prot

Q05117

Related

ENSMUSP00000149597.2, ENSMUST00000213815.2

Conserved Domains (1) summary

cd07378
Location:28 → 313

MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain