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    Pisd phosphatidylserine decarboxylase [ Mus musculus (house mouse) ]

    Gene ID: 320951, updated on 9-May-2024

    Summary

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    Official Symbol
    Pisdprovided by MGI
    Official Full Name
    phosphatidylserine decarboxylaseprovided by MGI
    Primary source
    MGI:MGI:2445114
    See related
    Ensembl:ENSMUSG00000023452 AllianceGenome:MGI:2445114
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9030221M09Rik
    Summary
    Predicted to enable phosphatidylserine decarboxylase activity. Predicted to be involved in mitochondrial protein catabolic process; phosphatidylethanolamine biosynthetic process; and regulation of mitochondrion organization. Predicted to act upstream of or within lipid metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PISD (phosphatidylserine decarboxylase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 35.1), duodenum adult (RPKM 34.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pisd in Genome Data Viewer
    Location:
    5 B1; 5 17.33 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (32893645..32943008, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (32736301..32785642, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12801 Neighboring gene predicted gene 10461 Neighboring gene YES proto-oncogene 1, Src family tyrosine kinase Neighboring gene STARR-seq mESC enhancer starr_12803 Neighboring gene predicted gene 2420 Neighboring gene predicted gene, 52771 Neighboring gene STARR-seq mESC enhancer starr_12804 Neighboring gene STARR-positive B cell enhancer ABC_E4751 Neighboring gene proline rich 14-like Neighboring gene STARR-positive B cell enhancer ABC_E10312 Neighboring gene ribosomal protein L37 pseudogene Neighboring gene DEP domain containing 5 Neighboring gene predicted gene, 24003

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Phosphatidylserine decarboxylase is critical for the maintenance of skeletal muscle mitochondrial integrity and muscle mass. Selathurai A, et al. Mol Metab, 2019 Sep. PMID 31285171, Free PMC Article
    2. Limited RNA editing in exons of mouse liver and adipose. Lagarrigue S, et al. Genetics, 2013 Apr. PMID 23410828, Free PMC Article
    3. Disruption of the phosphatidylserine decarboxylase gene in mice causes embryonic lethality and mitochondrial defects. Steenbergen R, et al. J Biol Chem, 2005 Dec 2. PMID 16192276, Free PMC Article
    4. Single-cell architecture and functional requirement of alternative splicing during hematopoietic stem cell formation. Wang F, et al. Sci Adv, 2022 Jan 7. PMID 34995116, Free PMC Article
    5. Vesicular monoamine transporter 2 and dopamine transporter are molecular targets of Pitx3 in the ventral midbrain dopamine neurons. Hwang DY, et al. J Neurochem, 2009 Dec. PMID 19780901, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The phosphatidylserine decarboxylase pathway has a significant role in maintaining phospholipid homeostasis in adult skeletal muscle. Moreover, phosphatidylserine decarboxylase is essential for maintenance of mitochondrial integrity and skeletal muscle mass.
      Title: Phosphatidylserine decarboxylase is critical for the maintenance of skeletal muscle mitochondrial integrity and muscle mass.
    2. phosphatidylserine decarboxylase in mice is required for embryonic survival and mitochondria
      Title: Disruption of the phosphatidylserine decarboxylase gene in mice causes embryonic lethality and mitochondrial defects.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carboxy-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylserine decarboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylserine decarboxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid droplet formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylethanolamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylethanolamine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylserine decarboxylase proenzyme, mitochondrial
    NP_001334261.1
    NP_796272.2
    XP_006504062.1
    XP_006504063.1
    XP_006504065.1
    XP_030110443.1
    XP_030110444.1
    XP_030110445.1
    XP_030110446.1
    XP_030110448.1
    XP_036021115.1
    XP_036021116.1
    XP_036021117.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347332.1 → NP_001334261.1  phosphatidylserine decarboxylase proenzyme, mitochondrial isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC241622
      Consensus CDS
      CCDS84866.1
      UniProtKB/TrEMBL
      E9PX91
      Related
      ENSMUSP00000112573.2, ENSMUST00000120591.8
      Conserved Domains (1) summary
      PLN02938
      Location:70 → 373
      PLN02938; phosphatidylserine decarboxylase

    2. NM_177298.3 → NP_796272.2  phosphatidylserine decarboxylase proenzyme, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_796272.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC070408, CX201846
      Consensus CDS
      CCDS19194.1
      UniProtKB/Swiss-Prot
      Q8BSD6, Q8BSF4
      UniProtKB/TrEMBL
      Q3TRI5, Q505E1
      Related
      ENSMUSP00000051438.10, ENSMUST00000061895.16
      Conserved Domains (1) summary
      cl03656
      Location:148 → 404
      PS_Dcarbxylase; Phosphatidylserine decarboxylase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      32893645..32943008 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165223.1 → XP_036021116.1  phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X4

      Conserved Domains (1) summary
      PLN02938
      Location:131 → 434
      PLN02938; phosphatidylserine decarboxylase

    2. XM_030254586.1 → XP_030110446.1  phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X5

      UniProtKB/TrEMBL
      Q3TJ76
      Conserved Domains (1) summary
      PLN02938
      Location:3 → 301
      PLN02938; phosphatidylserine decarboxylase

    3. XM_006503999.4 → XP_006504062.1  phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_006504062.1

      UniProtKB/TrEMBL
      E9PX91
      Conserved Domains (1) summary
      PLN02938
      Location:70 → 373
      PLN02938; phosphatidylserine decarboxylase

    4. XM_036165222.1 → XP_036021115.1  phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X1

      Conserved Domains (1) summary
      PLN02938
      Location:83 → 386
      PLN02938; phosphatidylserine decarboxylase

    5. XM_030254583.1 → XP_030110443.1  phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X2

      UniProtKB/TrEMBL
      E9PX91
      Conserved Domains (1) summary
      PLN02938
      Location:70 → 373
      PLN02938; phosphatidylserine decarboxylase

    6. XM_006504000.5 → XP_006504063.1  phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_006504063.1

      UniProtKB/TrEMBL
      E9PX91
      Conserved Domains (1) summary
      PLN02938
      Location:70 → 373
      PLN02938; phosphatidylserine decarboxylase

    7. XM_030254585.2 → XP_030110445.1  phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X2

      UniProtKB/TrEMBL
      E9PX91
      Conserved Domains (1) summary
      PLN02938
      Location:70 → 373
      PLN02938; phosphatidylserine decarboxylase

    8. XM_030254584.2 → XP_030110444.1  phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X2

      UniProtKB/TrEMBL
      E9PX91
      Conserved Domains (1) summary
      PLN02938
      Location:70 → 373
      PLN02938; phosphatidylserine decarboxylase

    9. XM_030254588.2 → XP_030110448.1  phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X5

      UniProtKB/TrEMBL
      Q3TJ76
      Conserved Domains (1) summary
      PLN02938
      Location:3 → 301
      PLN02938; phosphatidylserine decarboxylase

    10. XM_036165224.1 → XP_036021117.1  phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X5

      UniProtKB/TrEMBL
      Q3TJ76
      Conserved Domains (1) summary
      PLN02938
      Location:3 → 301
      PLN02938; phosphatidylserine decarboxylase

    11. XM_006504002.4 → XP_006504065.1  phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X3

      Conserved Domains (1) summary
      PLN02938
      Location:35 → 338
      PLN02938; phosphatidylserine decarboxylase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BSF4.1 GenPept UniProtKB/Swiss-Prot:Q8BSF4

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