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    Zscan26 zinc finger and SCAN domain containing 26 [ Mus musculus (house mouse) ]

    Gene ID: 432731, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zscan26provided by MGI
    Official Full Name
    zinc finger and SCAN domain containing 26provided by MGI
    Primary source
    MGI:MGI:3531417
    See related
    Ensembl:ENSMUSG00000022228 AllianceGenome:MGI:3531417
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfp187; Znf187
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including gut; metatarsal bone; rest of cerebellum ventricular layer; sensory organ; and telencephalon. Orthologous to human ZSCAN26 (zinc finger and SCAN domain containing 26). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 25.1), cerebellum adult (RPKM 17.0) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zscan26 in Genome Data Viewer
    Location:
    13 A3.1; 13 7.8 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (21626344..21637901, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (21442180..21453727, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene zinc finger with KRAB and SCAN domains 3 Neighboring gene STARR-seq mESC enhancer starr_33849 Neighboring gene STARR-positive B cell enhancer ABC_E10783 Neighboring gene microRNA 6942 Neighboring gene piggyBac transposable element derived 1 Neighboring gene RIKEN cDNA 4930470G03 gene Neighboring gene microRNA 1896 Neighboring gene STARR-positive B cell enhancer ABC_E11532 Neighboring gene NFKB activating protein-like Neighboring gene zinc finger with KRAB and SCAN domains 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Comprehensive interactome of Otx2 in the adult mouse neural retina. Fant B, et al. Genesis, 2015 Nov. PMID 26426291
    2. The central role of EED in the orchestration of polycomb group complexes. Cao Q, et al. Nat Commun, 2014. PMID 24457600, Free PMC Article
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and SCAN domain-containing protein 26
    Names
    zinc finger protein 187

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013786.4 → NP_001013808.2  zinc finger and SCAN domain-containing protein 26 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two alternate in-frame exons in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
      Source sequence(s)
      BX001068
      Consensus CDS
      CCDS49211.1
      UniProtKB/TrEMBL
      F8WJ31
      Related
      ENSMUSP00000032820.7, ENSMUST00000032820.15
      Conserved Domains (3) summary
      COG5048
      Location:136 → 297
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:146 → 166
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:158 → 183
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001347491.2 → NP_001334420.1  zinc finger and SCAN domain-containing protein 26 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      BX001068
      Consensus CDS
      CCDS84009.1
      UniProtKB/Swiss-Prot
      Q5RJ54, Q6NVD7
      Related
      ENSMUSP00000106111.2, ENSMUST00000110485.3
      Conserved Domains (3) summary
      COG5048
      Location:253 → 463
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:272 → 292
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02605
      Location:43 → 151
      SCAN; SCAN oligomerization domain

    3. NM_001426343.1 → NP_001413272.1  zinc finger and SCAN domain-containing protein 26 isoform a

      Status: VALIDATED

      Source sequence(s)
      BX001068
      UniProtKB/Swiss-Prot
      Q5RJ54, Q6NVD7

    4. NM_001426344.1 → NP_001413273.1  zinc finger and SCAN domain-containing protein 26 isoform 3

      Status: VALIDATED

      Source sequence(s)
      BX001068

    5. NM_001426345.1 → NP_001413274.1  zinc finger and SCAN domain-containing protein 26 isoform 4

      Status: VALIDATED

      Source sequence(s)
      BX001068

    6. NM_001426346.1 → NP_001413275.1  zinc finger and SCAN domain-containing protein 26 isoform 5

      Status: VALIDATED

      Source sequence(s)
      BX001068

    7. NM_001426347.1 → NP_001413276.1  zinc finger and SCAN domain-containing protein 26 isoform 6

      Status: VALIDATED

      Source sequence(s)
      BX001068

    8. NM_001426348.1 → NP_001413277.1  zinc finger and SCAN domain-containing protein 26 isoform 7

      Status: VALIDATED

      Source sequence(s)
      BX001068

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      21626344..21637901 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5RJ54.1 GenPept UniProtKB/Swiss-Prot:Q5RJ54

    Gene LinkOut

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