Kcnk4 potassium channel, subfamily K, member 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcnk4provided by MGI
Official Full Name: potassium channel, subfamily K, member 4provided by MGI
Primary source: MGI:MGI:1298234
See related: Ensembl:ENSMUSG00000024957 AllianceGenome:MGI:1298234
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TRAAK; Tex40; TRAAKt; MLZ-622; Catsperz
Summary: Predicted to enable cation channel activity and identical protein binding activity. Involved in detection of mechanical stimulus involved in sensory perception of touch; sensory perception of pain; and sensory perception of temperature stimulus. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of potassium channel complex. Predicted to be integral component of plasma membrane. Is expressed in 2-cell stage embryo; blastocyst; early conceptus; secondary oocyte; and spermatid. Orthologous to human KCNK4 (potassium two pore domain channel subfamily K member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 71.0) and cortex adult (RPKM 5.7) See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 5.08 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (6903030..6912261, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (6925662..6934883, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hyperoxia treatment of TREK-1/TREK-2/TRAAK-deficient mice is associated with a reduction in surfactant proteins
Title: Hyperoxia treatment of TREK-1/TREK-2/TRAAK-deficient mice is associated with a reduction in surfactant proteins.
The beneficial effects of TRAAK deletion designate this channel as a promising pharmacological target for the treatment against stroke.
Title: Deletion of TRAAK potassium channel affects brain metabolism and protects against ischemia.
Polycystins protect renal epithelial cells against apoptosis in response to mechanical stress, and this function is mediated through the opening of stretch-activated K(2P) channels.
Title: Mechanoprotection by polycystins against apoptosis is mediated through the opening of stretch-activated K(2P) channels.
The TRAAK appears to be strongly involved in regulating airway mechanosensing since it was found to be expressed on the terminals of all subpopulations of potential vagal mechanosensors.
Title: Expression of mechanogated two-pore domain potassium channels in mouse lungs: special reference to mechanosensory airway receptors.
Together TREK-1 and TRAAK channels are important regulators of nociceptor activation by cold, particularly in the nociceptor population that is not activated by menthol.
Title: The mechano-activated K+ channels TRAAK and TREK-1 control both warm and cold perception.
TREK-1, TREK-2, and TRAAK are lysophosphatidic acid-operated K+ channels
Title: Lysophosphatidic acid-operated K+ channels.
primary observation is that the mechanosensitive K2P channels TREK-1 and TRAAK desensitize; desensitization and its regulation by chemical messengers is predicted to condition the physiological role of K2P channels
Title: Desensitization of mechano-gated K2P channels.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (1) 1 citation

General gene information

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Markers

Kcnk4 (e-PCR), detects polymorphism
- UniSTS:547597

Kcnk4 (e-PCR), detects polymorphism
- UniSTS:547598

NoName (e-PCR)
- UniSTS:493355

Kcnk4 (e-PCR), detects polymorphism
- UniSTS:143671

UniSTS:166286 (e-PCR)
- UniSTS:166286

Kcnk4 (e-PCR), detects polymorphism
- UniSTS:166286

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables mechanosensitive potassium channel activity	ISO Inferred from Sequence Orthology more info
enables outward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel activity	ISO Inferred from Sequence Orthology more info
enables potassium ion leak channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables temperature-gated cation channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to fatty acid	ISO Inferred from Sequence Orthology more info
involved_in cellular response to mechanical stimulus	ISO Inferred from Sequence Orthology more info
involved_in detection of mechanical stimulus involved in sensory perception of touch	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of temperature stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stabilization of membrane potential	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of potassium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: potassium channel subfamily K member 4

Names: TWIK-related arachidonic acid-stimulated potassium channel protein; catSper-zeta; catSperzeta; protein expressed in male leptotene and zygotene spermatocytes 622; testis-expressed protein 40

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001403912.1 → NP_001390841.1 potassium channel subfamily K member 4 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC120557

UniProtKB/Swiss-Prot

O88454

UniProtKB/TrEMBL

Q0VD85

Related

ENSMUSP00000159967.1, ENSMUST00000249872.1
NM_001403913.1 → NP_001390842.1 potassium channel subfamily K member 4 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC120557

UniProtKB/Swiss-Prot

O88454

UniProtKB/TrEMBL

Q0VD85

Related

ENSMUSP00000159966.1, ENSMUST00000249871.1
NM_001403914.1 → NP_001390843.1 potassium channel subfamily K member 4 isoform 2

Status: VALIDATED

Source sequence(s)

AC120557
NM_001403915.1 → NP_001390844.1 potassium channel subfamily K member 4 isoform 2

Status: VALIDATED

Source sequence(s)

AC120557
NM_001403916.1 → NP_001390845.1 potassium channel subfamily K member 4 isoform 3

Status: VALIDATED

Source sequence(s)

AC120557
NM_008431.4 → NP_032457.1 potassium channel subfamily K member 4 isoform 1 precursor

See identical proteins and their annotated locations for NP_032457.1

Status: VALIDATED

Source sequence(s)

AC120557

Consensus CDS

CCDS29511.1

UniProtKB/Swiss-Prot

O88454

UniProtKB/TrEMBL

Q0VD85

Related

ENSMUSP00000025908.7, ENSMUST00000025908.8

Conserved Domains (2) summary

TIGR02927
Location:281 → 352

SucB_Actino; 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase

pfam07885
Location:89 → 143

Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

6903030..6912261 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006526717.5 → XP_006526780.1 potassium channel subfamily K member 4 isoform X2

Conserved Domains (2) summary

TIGR02927
Location:310 → 381

SucB_Actino; 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase

pfam07885
Location:210 → 288

Ion_trans_2; Ion channel
XM_036161450.1 → XP_036017343.1 potassium channel subfamily K member 4 isoform X7

Conserved Domains (1) summary

pfam07885
Location:135 → 189

Ion_trans_2; Ion channel
XM_006526720.4 → XP_006526783.1 potassium channel subfamily K member 4 isoform X5

See identical proteins and their annotated locations for XP_006526783.1

UniProtKB/Swiss-Prot

O88454

UniProtKB/TrEMBL

Q0VD85

Conserved Domains (2) summary

TIGR02927
Location:281 → 352

SucB_Actino; 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase

pfam07885
Location:89 → 143

Ion_trans_2; Ion channel
XM_006526719.3 → XP_006526782.1 potassium channel subfamily K member 4 isoform X4

See identical proteins and their annotated locations for XP_006526782.1

Conserved Domains (2) summary

TIGR02927
Location:307 → 378

SucB_Actino; 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase

pfam07885
Location:115 → 169

Ion_trans_2; Ion channel
XM_006526721.1 → XP_006526784.1 potassium channel subfamily K member 4 isoform X6

Conserved Domains (2) summary

TIGR02927
Location:270 → 341

SucB_Actino; 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase

pfam07885
Location:170 → 248

Ion_trans_2; Ion channel