Ctla2b cytotoxic T lymphocyte-associated protein 2 beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ctla2bprovided by MGI
Official Full Name: cytotoxic T lymphocyte-associated protein 2 betaprovided by MGI
Primary source: MGI:MGI:88555
See related: Ensembl:ENSMUSG00000074874 AllianceGenome:MGI:88555
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ctla-2b
Summary: Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in cellular protein catabolic process. Predicted to be active in extracellular space and lysosome. Is expressed in several structures, including blood; extraembryonic component; female reproductive system; and lung. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in placenta adult (RPKM 17.6), liver E18 (RPKM 2.8) and 9 other tissues See more
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Genomic context

Location:: 13 B2; 13 32.53 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (61043165..61045269, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (60895351..60897934, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CTLA-2 secretion is induced by dendritic cells to enhance regulatory T cell conversion after administration of cholera toxin and cAMP
Title: Low doses of cholera toxin and its mediator cAMP induce CTLA-2 secretion by dendritic cells to enhance regulatory T cell conversion.
expression of CTLA-2beta in the decidua may regulate implantation of the embryo by neutralizing the activities of one or more proteases generated by the proliferating trophoblast
Title: Induction of cytotoxic T-lymphocyte antigen-2beta, a cysteine protease inhibitor in decidua: a potential regulator of embryo implantation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase inhibitor activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: protein CTLA-2-beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145801.2 → NP_001139273.1 protein CTLA-2-beta isoform b

See identical proteins and their annotated locations for NP_001139273.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (b) has a distinct C-terminus and is shorter than isoform a.

Source sequence(s)

AC160962, CT010498

Consensus CDS

CCDS49288.1

UniProtKB/TrEMBL

A0A0R4J245, A0A286YD17

Related

ENSMUSP00000131083.2, ENSMUST00000171347.9

Conserved Domains (1) summary

smart00848
Location:16 → 74

Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
NM_001428483.1 → NP_001415412.1 protein CTLA-2-beta isoform a

Status: VALIDATED

Source sequence(s)

AC160962, CT010498

UniProtKB/Swiss-Prot

P12400, Q3UBK9, Q541S2
NM_007797.2 → NP_031823.1 protein CTLA-2-beta isoform a

See identical proteins and their annotated locations for NP_031823.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (a).

Source sequence(s)

AC160962, CT010498

Consensus CDS

CCDS49289.1

UniProtKB/Swiss-Prot

P12400, Q3UBK9, Q541S2

UniProtKB/TrEMBL

A0A286YD17

Related

ENSMUSP00000021884.9, ENSMUST00000021884.10

Conserved Domains (1) summary

smart00848
Location:16 → 74

Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

RNA

NR_190375.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC160962, CT010498

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

61043165..61045269 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011244472.2 → XP_011242774.1 protein CTLA-2-beta isoform X1

Conserved Domains (1) summary

smart00848
Location:16 → 74

Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)