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    FPK1 serine/threonine protein kinase FPK1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855783, updated on 17-May-2024

    Summary

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    Gene symbol
    FPK1
    Gene description
    serine/threonine protein kinase FPK1
    Primary source
    FungiDB:YNR047W
    Locus tag
    YNR047W
    See related
    SGD:S000005330; AllianceGenome:SGD:S000005330
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein serine/threonine kinase activity. Involved in several processes, including negative regulation of protein kinase activity by regulation of protein phosphorylation; positive regulation of cellular component organization; and protein phosphorylation. Located in cytoplasm; mating projection tip; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See FPK1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (708523..711204)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Pet494p Neighboring gene RNA methylation protein TRM112 Neighboring gene putative aminophospholipid translocase regulatory protein Neighboring gene Mso1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Single nucleotide mapping of trait space reveals Pareto fronts that constrain adaptation. Li Y, et al. Nat Ecol Evol, 2019 Nov. PMID 31611676, Free PMC Article
    2. Mutations in N-terminal flanking region of blue light-sensing light-oxygen and voltage 2 (LOV2) domain disrupt its repressive activity on kinase domain in the Chlamydomonas phototropin. Aihara Y, et al. J Biol Chem, 2012 Mar 23. PMID 22291022, Free PMC Article
    3. TOR Complex 2-Regulated Protein Kinase Fpk1 Stimulates Endocytosis via Inhibition of Ark1/Prk1-Related Protein Kinase Akl1 in Saccharomyces cerevisiae. Roelants FM, et al. Mol Cell Biol, 2017 Apr 1. PMID 28069741, Free PMC Article
    4. Protein kinases Fpk1p and Fpk2p are novel regulators of phospholipid asymmetry. Nakano K, et al. Mol Biol Cell, 2008 Apr. PMID 18199685, Free PMC Article
    5. An optogenetic system to control membrane phospholipid asymmetry through flippase activation in budding yeast. Suzuki T, et al. Sci Rep, 2020 Jul 27. PMID 32719316, Free PMC Article

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of clathrin-dependent endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of phospholipid translocation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to pheromone triggering conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mating projection tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine protein kinase FPK1
    NP_014445.1
    • Ser/Thr protein kinase; phosphorylates several aminophospholipid translocase family members, regulating phospholipid translocation and membrane asymmetry; phosphorylates and inhibits the protein kinase Akl1p, stimulating endocytosis; phosphorylates and inhibits upstream inhibitory kinase Ypk1p; localizes to the cytoplasm, early endosome/TGN, the plasma membrane and the shmoo tip; redundant role with KIN82 in the mating pheromone response; activity stimulated by Gin4p kinase and sphingolipid MIPC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      708523..711204
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183224.1 → NP_014445.1  TPA: serine/threonine protein kinase FPK1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014445.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1M2, P53739
      UniProtKB/TrEMBL
      A0A8H4BXC9, C8ZFS6, N1NXT7
      Conserved Domains (1) summary
      cd05574
      Location:494 → 797
      STKc_phototropin_like; Catalytic domain of Phototropin-like Serine/Threonine Kinases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53739.1

    Gene LinkOut

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