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    Dnajc14 DnaJ heat shock protein family (Hsp40) member C14 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114481, updated on 5-Mar-2024

    Summary

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    Symbol
    Dnajc14provided by RGD
    Full Name
    DnaJ heat shock protein family (Hsp40) member C14provided by RGD
    Primary source
    RGD:620489
    See related
    Ensembl:ENSRNOG00000006844 AllianceGenome:RGD:620489
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Drip78
    Summary
    Enables dopamine receptor binding activity. Predicted to be involved in protein transport. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Orthologous to human DNAJC14 (DnaJ heat shock protein family (Hsp40) member C14). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 153.4), Heart (RPKM 138.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dnajc14 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (1818360..1831642)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (1233856..1247349)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (3229026..3242265)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene PYM homolog 1, exon junction complex associated factor Neighboring gene matrix metallopeptidase 19 Neighboring gene transmembrane protein 198b Neighboring gene ORMDL sphingolipid biosynthesis regulator 2 Neighboring gene SAP domain containing ribonucleoprotein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Regulation of transport of the dopamine D1 receptor by a new membrane-associated ER protein. Bermak JC, et al. Nat Cell Biol, 2001 May. PMID 11331877
    2. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93289

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dopamine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dopamine receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dnaJ homolog subfamily C member 14
    Names
    DnaJ (Hsp40) homolog, subfamily C, member 14
    dnaJ homolog subfamily C member 14-like
    dopamine receptor interacting protein
    dopamine receptor-interacting protein of 78 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053690.2 → NP_446142.2  dnaJ homolog subfamily C member 14

      See identical proteins and their annotated locations for NP_446142.2

      Status: VALIDATED

      Source sequence(s)
      AA957791, BC083549, BP502976
      UniProtKB/Swiss-Prot
      Q5XIX0, Q925G7
      UniProtKB/TrEMBL
      A6KSJ1, A6KSJ2
      Related
      ENSRNOP00000029946.3, ENSRNOT00000037332.4
      Conserved Domains (2) summary
      pfam00226
      Location:444 → 505
      DnaJ; DnaJ domain
      pfam14901
      Location:535 → 621
      Jiv90; Cleavage inducing molecular chaperone

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      1818360..1831642
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240727.4 → XP_006240789.1  dnaJ homolog subfamily C member 14 isoform X1

      See identical proteins and their annotated locations for XP_006240789.1

      UniProtKB/Swiss-Prot
      Q5XIX0, Q925G7
      UniProtKB/TrEMBL
      A6KSJ1, A6KSJ2
      Conserved Domains (2) summary
      pfam00226
      Location:444 → 505
      DnaJ; DnaJ domain
      pfam14901
      Location:535 → 621
      Jiv90; Cleavage inducing molecular chaperone

    2. XM_006240726.3 → XP_006240788.1  dnaJ homolog subfamily C member 14 isoform X1

      See identical proteins and their annotated locations for XP_006240788.1

      UniProtKB/Swiss-Prot
      Q5XIX0, Q925G7
      UniProtKB/TrEMBL
      A6KSJ1, A6KSJ2
      Conserved Domains (2) summary
      pfam00226
      Location:444 → 505
      DnaJ; DnaJ domain
      pfam14901
      Location:535 → 621
      Jiv90; Cleavage inducing molecular chaperone

    3. XM_008765011.4 → XP_008763233.1  dnaJ homolog subfamily C member 14 isoform X1

      See identical proteins and their annotated locations for XP_008763233.1

      UniProtKB/Swiss-Prot
      Q5XIX0, Q925G7
      UniProtKB/TrEMBL
      A6KSJ1, A6KSJ2
      Conserved Domains (2) summary
      pfam00226
      Location:444 → 505
      DnaJ; DnaJ domain
      pfam14901
      Location:535 → 621
      Jiv90; Cleavage inducing molecular chaperone

    4. XM_039078240.2 → XP_038934168.1  dnaJ homolog subfamily C member 14 isoform X2

      Conserved Domains (2) summary
      pfam14901
      Location:72 → 160
      Jiv90; Cleavage inducing molecular chaperone
      cl02542
      Location:9 → 44
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

    5. XM_017594567.3 → XP_017450056.1  dnaJ homolog subfamily C member 14 isoform X1

      UniProtKB/Swiss-Prot
      Q5XIX0, Q925G7
      UniProtKB/TrEMBL
      A6KSJ1, A6KSJ2
      Conserved Domains (2) summary
      pfam00226
      Location:444 → 505
      DnaJ; DnaJ domain
      pfam14901
      Location:535 → 621
      Jiv90; Cleavage inducing molecular chaperone
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XIX0.1 GenPept UniProtKB/Swiss-Prot:Q5XIX0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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