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    Polr2h RNA polymerase II, I and III subunit H [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498109, updated on 5-Mar-2024

    Summary

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    Symbol
    Polr2hprovided by RGD
    Full Name
    RNA polymerase II, I and III subunit Hprovided by RGD
    Primary source
    RGD:1561203
    See related
    Ensembl:ENSRNOG00000001748 AllianceGenome:RGD:1561203
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RPB17; RGD1561203
    Summary
    Predicted to enable single-stranded DNA binding activity. Predicted to be involved in transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of nuclear DNA-directed RNA polymerase complex and protein-DNA complex. Orthologous to human POLR2H (RNA polymerase II, I and III subunit H). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 132.3), Spleen (RPKM 107.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Polr2h in Genome Data Viewer
    Location:
    11q23
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (93696423..93701902, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (80192017..80197468, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (83877760..83882208, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene chordin Neighboring gene thrombopoietin like 1 Neighboring gene chloride voltage-gated channel 2 Neighboring gene family with sequence similarity 131, member A Neighboring gene eukaryotic translation initiation factor 4 gamma 1 Neighboring gene small nucleolar RNA, C/D box 66

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structural, biochemical, and dynamic characterizations of the hRPB8 subunit of human RNA polymerases. Kang X, et al. J Biol Chem, 2006 Jun 30. PMID 16632472
    2. Perinatal regulation of the ClC-2 chloride channel in lung is mediated by Sp1 and Sp3. Chu S, et al. Am J Physiol, 1999 Apr. PMID 10198359
    3. Structure and function of RNA polymerase II elongation factor ELL. Identification of two overlapping ELL functional domains that govern its interaction with polymerase and the ternary elongation complex. Shilatifard A, et al. J Biol Chem, 1997 Aug 29. PMID 9268387
    4. Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. Kershnar E, et al. J Biol Chem, 1998 Dec 18. PMID 9852112
    5. Gene expression analysis in response to lung toxicants: I. Sequencing and microarray development. Shultz MA, et al. Am J Respir Cell Mol Biol, 2004 Mar. PMID 12947022

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to RNA polymerase I activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase II activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase III activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in transcription by RNA polymerase I IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription by RNA polymerase III IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase I complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of RNA polymerase II, core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase II, core complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase III complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-DNA complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA-directed RNA polymerases I, II, and III subunit RPABC3
    Names
    DNA-directed RNA polymerases I, II, and III subunit RPABC3-like
    RNA polymerase II subunit H
    polymerase (RNA) II (DNA directed) polypeptide H
    polymerase (RNA) II subunit H
    NP_001128261.1
    XP_038944511.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134789.1 → NP_001128261.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3

      See identical proteins and their annotated locations for NP_001128261.1

      Status: VALIDATED

      Source sequence(s)
      BQ210721, CB699618, CB758009, CF113682
      UniProtKB/TrEMBL
      A6JS83, G3V678
      Related
      ENSRNOP00000002382.4, ENSRNOT00000002382.6
      Conserved Domains (1) summary
      smart00658
      Location:2 → 147
      RPOL8c; RNA polymerase subunit 8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      93696423..93701902 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088583.2 → XP_038944511.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform X1

      UniProtKB/TrEMBL
      A6JS84
      Conserved Domains (1) summary
      smart00658
      Location:2 → 106
      RPOL8c; RNA polymerase subunit 8
    Nucleotide Protein Strain
    Heading Accession and Version

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