Sart3 spliceosome associated factor 3, U4/U6 recycling protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sart3provided by RGD
Official Full Name: spliceosome associated factor 3, U4/U6 recycling proteinprovided by RGD
Primary source: RGD:1311646
See related: Ensembl:ENSRNOG00000000702 AllianceGenome:RGD:1311646
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable histone binding activity; snRNA binding activity; and ubiquitin-specific protease binding activity. Predicted to be involved in nucleosome assembly; positive regulation of histone deubiquitination; and spliceosomal tri-snRNP complex assembly. Predicted to act upstream of or within several processes, including cell morphogenesis; hematopoietic stem cell proliferation; and homeostasis of number of cells. Predicted to be located in Cajal body. Predicted to be part of ASAP complex. Predicted to be active in cytoplasm and nucleoplasm. Orthologous to human SART3 (spliceosome associated factor 3, U4/U6 recycling protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 61.4), Spleen (RPKM 52.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q16

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (48519579..48547584)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (42859026..42887041)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (48628198..48656096)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Sart3 (e-PCR), detects polymorphism
- UniSTS:479256

RH132969 (e-PCR)
- UniSTS:216252

SART3 (e-PCR)
- UniSTS:258303

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
NOT enables U4 snRNA binding	ISO Inferred from Sequence Orthology more info
enables U4 snRNA binding	ISO Inferred from Sequence Orthology more info
NOT enables U6 snRNA binding	ISO Inferred from Sequence Orthology more info
enables U6 snRNA binding	ISO Inferred from Sequence Orthology more info
enables U6atac snRNA binding	ISO Inferred from Sequence Orthology more info
enables histone binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-specific protease binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within cell morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hematopoietic stem cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within homeostasis of number of cells	ISO Inferred from Sequence Orthology more info
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in nucleosome assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
NOT involved_in spliceosomal snRNP assembly	ISO Inferred from Sequence Orthology more info
involved_in spliceosomal snRNP assembly	ISO Inferred from Sequence Orthology more info
involved_in spliceosomal tri-snRNP complex assembly	ISO Inferred from Sequence Orthology more info
involved_in transcription elongation-coupled chromatin remodeling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of ASAP complex	IBA Inferred from Biological aspect of Ancestor more info
located_in Cajal body	ISO Inferred from Sequence Orthology more info
part_of U4/U6 snRNP	ISO Inferred from Sequence Orthology more info
NOT part_of U4/U6 x U5 tri-snRNP complex	ISO Inferred from Sequence Orthology more info
NOT part_of U4atac/U6atac snRNP	ISO Inferred from Sequence Orthology more info
part_of U6atac snRNP	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: squamous cell carcinoma antigen recognized by T-cells 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107156.1 → NP_001100626.1 squamous cell carcinoma antigen recognized by T-cells 3

See identical proteins and their annotated locations for NP_001100626.1

Status: PROVISIONAL

Source sequence(s)

CH473973

UniProtKB/TrEMBL

A6J227

Conserved Domains (6) summary

COG5107
Location:99 → 459

RNA14; Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and modification]

cd12391
Location:703 → 776

RRM1_SART3; RNA recognition motif 1 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins

cd12392
Location:797 → 877

RRM2_SART3; RNA recognition motif 2 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins

pfam05391
Location:942 → 959

Lsm_interact; Lsm interaction motif

pfam08424
Location:332 → 485

NRDE-2; NRDE-2, necessary for RNA interference

pfam16605
Location:875 → 933

LSM_int_assoc; LSM-interacting associated unstructured

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

48519579..48547584

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006249501.5 → XP_006249563.1 squamous cell carcinoma antigen recognized by T-cells 3 isoform X1

UniProtKB/TrEMBL

D3ZAS8

Related

ENSRNOP00000000891.4

Conserved Domains (6) summary

COG5107
Location:99 → 477

RNA14; Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and modification]

cd12391
Location:721 → 794

RRM1_SART3; RNA recognition motif 1 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins

cd12392
Location:815 → 895

RRM2_SART3; RNA recognition motif 2 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins

pfam05391
Location:960 → 977

Lsm_interact; Lsm interaction motif

pfam08424
Location:350 → 503

NRDE-2; NRDE-2, necessary for RNA interference

pfam16605
Location:893 → 951

LSM_int_assoc; LSM-interacting associated unstructured
XM_006249502.4 → XP_006249564.1 squamous cell carcinoma antigen recognized by T-cells 3 isoform X2

See identical proteins and their annotated locations for XP_006249564.1

Conserved Domains (6) summary

COG5107
Location:4 → 346

RNA14; Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and modification]

cd12391
Location:590 → 663

RRM1_SART3; RNA recognition motif 1 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins

cd12392
Location:684 → 764

RRM2_SART3; RNA recognition motif 2 in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins

pfam05391
Location:829 → 846

Lsm_interact; Lsm interaction motif

pfam08424
Location:219 → 372

NRDE-2; NRDE-2, necessary for RNA interference

pfam16605
Location:762 → 820

LSM_int_assoc; LSM-interacting associated unstructured
XM_039089525.2 → XP_038945453.1 squamous cell carcinoma antigen recognized by T-cells 3 isoform X3

Conserved Domains (3) summary

pfam16605
Location:488 → 546

LSM_int_assoc; LSM-interacting associated unstructured

cd12391
Location:316 → 389

RRM1_SART3; RNA recognition motif 1 (RRM1) found in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins

cd12392
Location:410 → 490

RRM2_SART3; RNA recognition motif 2 (RRM2) found in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins