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    Tmem129 transmembrane protein 129, E3 ubiquitin ligase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305458, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Tmem129provided by RGD
    Official Full Name
    transmembrane protein 129, E3 ubiquitin ligaseprovided by RGD
    Primary source
    RGD:1310828
    See related
    Ensembl:ENSRNOG00000017329 AllianceGenome:RGD:1310828
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310828
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein polyubiquitination; retrograde protein transport, ER to cytosol; and ubiquitin-dependent ERAD pathway. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human TMEM129 (transmembrane protein 129, E3 ubiquitin ligase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 69.1), Thymus (RPKM 66.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmem129 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (81289852..81295416)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (77065391..77070871)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (82350734..82356084)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene small nucleolar RNA SNORA18 Neighboring gene transforming, acidic coiled-coil containing protein 3 Neighboring gene stem-loop histone mRNA binding protein Neighboring gene family with sequence similarity 53, member A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I. van den Boomen DJ, et al. Proc Natl Acad Sci U S A, 2014 Aug 5. PMID 25030448, Free PMC Article
    2. A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation. van de Weijer ML, et al. Nat Commun, 2014 May 8. PMID 24807418, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde protein transport, ER to cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase TM129
    NP_001119746.1
    XP_038947907.1
    XP_038947908.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001126274.1 → NP_001119746.1  E3 ubiquitin-protein ligase TM129

      See identical proteins and their annotated locations for NP_001119746.1

      Status: PROVISIONAL

      Source sequence(s)
      BC161857
      UniProtKB/TrEMBL
      B1WBR6
      Related
      ENSRNOP00000023259.4, ENSRNOT00000023259.6
      Conserved Domains (1) summary
      pfam10272
      Location:17 → 359
      Tmpp129; Putative transmembrane protein precursor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      81289852..81295416
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039091979.2 → XP_038947907.1  E3 ubiquitin-protein ligase TM129 isoform X1

      UniProtKB/TrEMBL
      B1WBR6
      Conserved Domains (1) summary
      pfam10272
      Location:17 → 359
      Tmpp129; Putative transmembrane protein precursor

    2. XM_039091980.2 → XP_038947908.1  E3 ubiquitin-protein ligase TM129 isoform X2

      Conserved Domains (1) summary
      pfam10272
      Location:1 → 288
      Tmpp129; Putative transmembrane protein precursor
    Nucleotide Protein Strain
    Heading Accession and Version

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