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    Otud7b OTU deubiquitinase 7B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310677, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Otud7bprovided by RGD
    Official Full Name
    OTU deubiquitinase 7Bprovided by RGD
    Primary source
    RGD:1308111
    See related
    Ensembl:ENSRNOG00000042068 AllianceGenome:RGD:1308111
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308111
    Summary
    Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity; Lys48-specific deubiquitinase activity; and thiol-dependent deubiquitinase. Predicted to be involved in several processes, including negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of macromolecule metabolic process; and protein deubiquitination. Predicted to act upstream of or within in utero embryonic development and protein deubiquitination. Predicted to be active in cytoplasm and nucleus. Orthologous to human OTUD7B (OTU deubiquitinase 7B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 94.1), Heart (RPKM 90.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Otud7b in Genome Data Viewer
    Location:
    2q34
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (186350811..186411461)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (183661955..183722584)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (198231353..198302220)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein eL8-like Neighboring gene uncharacterized LOC134485652 Neighboring gene uncharacterized LOC134485654 Neighboring gene developmental pluripotency-associated 4, pseudogene 7 Neighboring gene myotubularin related protein 11 Neighboring gene splicing factor 3B subunit 4 Neighboring gene synaptic vesicle glycoprotein 2a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. OTUD7B (Cezanne) ameliorates fibrosis after myocardial infarction via FAK-ERK/P38 MAPK signaling pathway. Zhang J, et al. Arch Biochem Biophys, 2022 Jul 30. PMID 35523269
    2. Transcranial direct-current stimulation protects against cerebral ischemia-reperfusion injury through regulating Cezanne-dependent signaling. Cheng J, et al. Exp Neurol, 2021 Nov. PMID 34324860
    3. Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination. Luong le A, et al. Circ Res, 2013 Jun 7. PMID 23564640, Free PMC Article
    4. A novel type of deubiquitinating enzyme. Evans PC, et al. J Biol Chem, 2003 Jun 20. PMID 12682062
    5. Isolation and characterization of two novel A20-like proteins. Evans PC, et al. Biochem J, 2001 Aug 1. PMID 11463333, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ovarian Tumor Domain-Containing 7B Attenuates Pathological Cardiac Hypertrophy by Inhibiting Ubiquitination and Degradation of Kruppel-Like Factor 4.
      Title: Ovarian Tumor Domain-Containing 7B Attenuates Pathological Cardiac Hypertrophy by Inhibiting Ubiquitination and Degradation of Krüppel-Like Factor 4.
    2. OTUD7B (Cezanne) ameliorates fibrosis after myocardial infarction via FAK-ERK/P38 MAPK signaling pathway.
      Title: OTUD7B (Cezanne) ameliorates fibrosis after myocardial infarction via FAK-ERK/P38 MAPK signaling pathway.
    3. Transcranial direct-current stimulation protects against cerebral ischemia-reperfusion injury through regulating Cezanne-dependent signaling.
      Title: Transcranial direct-current stimulation protects against cerebral ischemia-reperfusion injury through regulating Cezanne-dependent signaling.
    4. Inflammatory responses to ischemia are controlled by a balance between ubiquitination and deubiquitination, and Cezanne is a key regulator of this process.
      Title: Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables K48-linked deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables K63-linked polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables K63-linked polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mucosal immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K11-linked deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K48-linked deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K63-linked deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein deubiquitination involved in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    OTU domain-containing protein 7B
    Names
    OTU domain containing 7B
    cellular zinc finger anti-NF-kappaB Cezanne
    NP_001101167.1
    XP_006233019.1
    XP_063137950.1
    XP_063137951.1
    XP_063137952.1
    XP_063137953.1
    XP_063137954.1
    XP_063137955.1
    XP_063137956.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107697.1 → NP_001101167.1  OTU domain-containing protein 7B

      See identical proteins and their annotated locations for NP_001101167.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474015
      UniProtKB/TrEMBL
      A0A0G2K5N0, A6K349
      Related
      ENSRNOP00000073488.2, ENSRNOT00000078288.2
      Conserved Domains (3) summary
      cd14347
      Location:4 → 46
      UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
      pfam01754
      Location:799 → 821
      zf-A20; A20-like zinc finger
      cl19932
      Location:189 → 359
      OTU; OTU-like cysteine protease

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      186350811..186411461
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281883.1 → XP_063137953.1  OTU domain-containing protein 7B isoform X1

      UniProtKB/TrEMBL
      A0A0G2K5N0, A6K349

    2. XM_063281885.1 → XP_063137955.1  OTU domain-containing protein 7B isoform X1

      UniProtKB/TrEMBL
      A0A0G2K5N0, A6K349

    3. XM_063281880.1 → XP_063137950.1  OTU domain-containing protein 7B isoform X1

      UniProtKB/TrEMBL
      A0A0G2K5N0, A6K349

    4. XM_006232957.5 → XP_006233019.1  OTU domain-containing protein 7B isoform X1

      See identical proteins and their annotated locations for XP_006233019.1

      UniProtKB/TrEMBL
      A0A0G2K5N0, A6K349
      Conserved Domains (3) summary
      cd14347
      Location:4 → 46
      UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
      pfam01754
      Location:799 → 821
      zf-A20; A20-like zinc finger
      cl19932
      Location:189 → 359
      OTU; OTU-like cysteine protease

    5. XM_063281882.1 → XP_063137952.1  OTU domain-containing protein 7B isoform X1

      UniProtKB/TrEMBL
      A0A0G2K5N0, A6K349

    6. XM_063281881.1 → XP_063137951.1  OTU domain-containing protein 7B isoform X1

      UniProtKB/TrEMBL
      A0A0G2K5N0, A6K349

    7. XM_063281886.1 → XP_063137956.1  OTU domain-containing protein 7B isoform X3

    8. XM_063281884.1 → XP_063137954.1  OTU domain-containing protein 7B isoform X2

      UniProtKB/TrEMBL
      A0A0G2K5N0
    Nucleotide Protein Strain
    Heading Accession and Version

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