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    Slc39a14 solute carrier family 39 member 14 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306009, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Slc39a14provided by RGD
    Official Full Name
    solute carrier family 39 member 14provided by RGD
    Primary source
    RGD:1307026
    See related
    Ensembl:ENSRNOG00000009832 AllianceGenome:RGD:1307026
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable anion:cation symporter activity and transition metal ion transmembrane transporter activity. Predicted to be involved in several processes, including negative regulation of cyclic-nucleotide phosphodiesterase activity; transition metal ion homeostasis; and transition metal ion transport. Predicted to act upstream of or within iron ion transport and zinc ion transport. Predicted to be located in apical plasma membrane; basolateral plasma membrane; and bounding membrane of organelle. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in hypermanganesemia with dystonia 2. Orthologous to human SLC39A14 (solute carrier family 39 member 14). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 477.0), Heart (RPKM 179.5) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc39a14 in Genome Data Viewer
    Location:
    15p11
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (51786517..51833260, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (45376806..45423549, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (51982872..52029841, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482142 Neighboring gene sorbin and SH3 domain containing 3 Neighboring gene protein phosphatase 3 catalytic subunit gamma Neighboring gene mitochondrial pyruvate carrier 1-like Neighboring gene histone deacetylase 1-like Neighboring gene piwi-like RNA-mediated gene silencing 2 Neighboring gene small nucleolar RNA SNORA70

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Metal Transporter Zip14 (Slc39a14) Deletion in Mice Increases Manganese Deposition and Produces Neurotoxic Signatures and Diminished Motor Activity. Aydemir TB, et al. J Neurosci, 2017 Jun 21. PMID 28536273, Free PMC Article
    2. Hepatic mobilization of zinc after an experimental surgery, and its relationship with inflammatory cytokines release, and expression of metallothionein and Zip14 transporter. Aburto-Luna V, et al. Inflamm Res, 2017 Feb. PMID 27785531
    3. Zip14 is a complex broad-scope metal-ion transporter whose functional properties support roles in the cellular uptake of zinc and nontransferrin-bound iron. Pinilla-Tenas JJ, et al. Am J Physiol Cell Physiol, 2011 Oct. PMID 21653899, Free PMC Article
    4. Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cells. Liuzzi JP, et al. Proc Natl Acad Sci U S A, 2006 Sep 12. PMID 16950869, Free PMC Article
    5. The intestinal metal transporter ZIP14 maintains systemic manganese homeostasis. Scheiber IF, et al. J Biol Chem, 2019 Jun 7. PMID 31028174, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. After tissue is damaged in abdominal surgery, cytokines are released to the circulation, IL-6, the main mediator of acute phase response induces the expression of MT and Zip14, and the increase of transporter Zip14 promotes the uptake of zinc by liver at the expense of serum zinc
      Title: Hepatic mobilization of zinc after an experimental surgery, and its relationship with inflammatory cytokines release, and expression of metallothionein and Zip14 transporter.
    2. Nuclear localization for Zip8 and Zip14 transporters as well as TfR1 was observed in the inner ear of rats.
      Title: Cellular localization and developmental changes of Zip8, Zip14 and transferrin receptor 1 in the inner ear of rats.
    3. Data suggest magnesium deficiency enhances liver zinc uptake by up-regulating expression of Zip14/Slc39a14 (solute carrier family 39, member 14); increased liver content of zinc leads to up-regulation of expression of metallothioneins (Mt1 and Mt2).
      Title: Magnesium and calcium deficiencies additively increase zinc concentrations and metallothionein expression in the rat liver.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cadmium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ferrous iron transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables iron ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables manganese ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monoatomic anion:monoatomic cation symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monoatomic cation:bicarbonate symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monoatomic cation:bicarbonate symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in bicarbonate transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cadmium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of chondrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inorganic cation transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular monoatomic cation homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular zinc ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in iron import into cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in iron ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within iron ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in manganese ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in manganese ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monoatomic anion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of regulation of hormone levels ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in zinc ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in zinc ion import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within zinc ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in zinc ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within zinc ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    metal cation symporter ZIP14
    Names
    solute carrier family 39 (zinc transporter), member 14
    zinc transporter ZIP14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107275.1 → NP_001100745.1  metal cation symporter ZIP14 precursor

      See identical proteins and their annotated locations for NP_001100745.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473951
      UniProtKB/TrEMBL
      A6HTK2, D3ZZM0
      Related
      ENSRNOP00000013066.2, ENSRNOT00000013067.4
      Conserved Domains (1) summary
      pfam02535
      Location:150 → 481
      Zip; ZIP Zinc transporter

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      51786517..51833260 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006252270.4 → XP_006252332.1  metal cation symporter ZIP14 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ABU1
      Related
      ENSRNOP00000091533.1
      Conserved Domains (1) summary
      pfam02535
      Location:151 → 481
      Zip; ZIP Zinc transporter

    2. XM_039093346.2 → XP_038949274.1  metal cation symporter ZIP14 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ABU1
      Conserved Domains (1) summary
      pfam02535
      Location:151 → 481
      Zip; ZIP Zinc transporter

    3. XM_039093343.2 → XP_038949271.1  metal cation symporter ZIP14 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ABU1
      Conserved Domains (1) summary
      pfam02535
      Location:151 → 481
      Zip; ZIP Zinc transporter

    4. XM_063274299.1 → XP_063130369.1  metal cation symporter ZIP14 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ABU1

    5. XM_039093347.2 → XP_038949275.1  metal cation symporter ZIP14 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ABU1
      Conserved Domains (1) summary
      pfam02535
      Location:151 → 481
      Zip; ZIP Zinc transporter

    6. XM_063274301.1 → XP_063130371.1  metal cation symporter ZIP14 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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