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    Gpr137b G protein-coupled receptor 137B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289287, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Gpr137bprovided by RGD
    Official Full Name
    G protein-coupled receptor 137Bprovided by RGD
    Primary source
    RGD:1307342
    See related
    Ensembl:ENSRNOG00000002480 AllianceGenome:RGD:1307342
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tm7sf1
    Summary
    Predicted to be involved in several processes, including negative regulation of bone resorption; positive regulation of TORC1 signaling; and positive regulation of protein localization to lysosome. Predicted to be integral component of membrane. Predicted to be active in lysosomal membrane. Orthologous to human GPR137B (G protein-coupled receptor 137B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 272.7), Kidney (RPKM 268.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gpr137b in Genome Data Viewer
    Location:
    17q12.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (92987792..93026003, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (86003635..86041841, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (90670852..90709003)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene EDAR associated via death domain Neighboring gene endoplasmic reticulum oxidoreductase 1 beta Neighboring gene nidogen 1 Neighboring gene uncharacterized LOC134482624

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Gpr137b is an orphan G-protein-coupled receptor associated with M2 macrophage polarization. Islam Z, et al. Biochem Biophys Res Commun, 2019 Feb 12. PMID 30595385
    2. A role for G protein-coupled receptor 137b in bone remodeling in mouse and zebrafish. Urso K, et al. Bone, 2019 Oct. PMID 31173907, Free PMC Article
    3. The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1 localization and activity. Gan L, et al. Nat Cell Biol, 2019 May. PMID 31036939, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in negative regulation of bone resorption IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of bone resorption ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of osteoclast differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization to lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of macrophage activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    integral membrane protein GPR137B
    Names
    transmembrane 7 superfamily member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399407.1 → NP_001386336.1  integral membrane protein GPR137B isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A8I6G770, D3ZK26
      Related
      ENSRNOP00000082259.1, ENSRNOT00000095724.1
      Conserved Domains (1) summary
      cd21476
      Location:20 → 339
      7tm_GPR137B; Integral membrane protein GPR137B, an orphan receptor member of the seven-transmembrane G protein-coupled receptor superfamily

    2. NM_001399408.1 → NP_001386337.1  integral membrane protein GPR137B isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A0G2K234, D3ZK26
      Related
      ENSRNOP00000072087.2, ENSRNOT00000081530.2
      Conserved Domains (1) summary
      cd21476
      Location:20 → 339
      7tm_GPR137B; Integral membrane protein GPR137B, an orphan receptor member of the seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      92987792..93026003 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039095436.2 → XP_038951364.1  integral membrane protein GPR137B isoform X1

      UniProtKB/TrEMBL
      D3ZK26
      Conserved Domains (2) summary
      cd21464
      Location:31 → 53
      7tm_GPR137; TM helix 1 [structural motif]
      cl28897
      Location:20 → 295
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001105978.1: Suppressed sequence

      Description
      NM_001105978.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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