Slc22a4 solute carrier family 22 member 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc22a4provided by RGD
Official Full Name: solute carrier family 22 member 4provided by RGD
Primary source: RGD:621149
See related: Ensembl:ENSRNOG00000046195 AllianceGenome:RGD:621149
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Octn1
Summary: Enables quaternary ammonium group transmembrane transporter activity. Involved in quaternary ammonium group transport. Predicted to be located in apical plasma membrane and mitochondrion. Human ortholog(s) of this gene implicated in rheumatoid arthritis. Orthologous to human SLC22A4 (solute carrier family 22 member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 105.6), Kidney (RPKM 96.3) and 5 other tissues See more
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Genomic context

Location:: 10q22

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (38634098..38687409, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (38133333..38179932, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (39334972..39373508, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lack of impact of OCTN1 gene polymorphisms on clinical outcomes of gabapentinoids in Pakistani patients with neuropathic pain.
Title: Lack of impact of OCTN1 gene polymorphisms on clinical outcomes of gabapentinoids in Pakistani patients with neuropathic pain.
the results obtained by the pointed out experimental model demonstrate that the organic cation transporter OCTN1 is expressed in peritoneum and is localized in mesothelial cells
Title: Acetylcholine and acetylcarnitine transport in peritoneum: Role of the SLC22A4 (OCTN1) transporter.
rat Octn1 is important by transporting anti-oxidant ergothioneine in PC12 cells
Title: Functional characterization of ergothioneine transport by rat organic cation/carnitine transporter Octn1 (slc22a4).
We conclude that PPARalpha agonists increase carnitine concentrations in livers of rats and cells by an increased uptake of carnitine into the cell but not by an increased carnitine biosynthesis.
Title: PPARalpha agonists up-regulate organic cation transporters in rat liver cells.

Submit: New GeneRIF Correction

General gene information

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Markers

Slc22a4 (e-PCR), detects polymorphism
- UniSTS:463371

D10Wox49 (e-PCR)
- UniSTS:518599

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables PDZ domain binding	IEA Inferred from Electronic Annotation more info
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables acetylcholine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables acetylcholine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables acetylcholine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables amino acid transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables amino-acid betaine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables amino-acid betaine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables amino-acid betaine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables carnitine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables carnitine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables organic cation transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables quaternary ammonium group transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables quaternary ammonium group transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables quaternary ammonium group transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables quaternary ammonium group transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables symporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acetate ester transport	IEA Inferred from Electronic Annotation more info
involved_in amino acid import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in amino acid import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in carnitine metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within carnitine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in carnitine transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within carnitine transport	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter transport	IEA Inferred from Electronic Annotation more info
involved_in quaternary ammonium group transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in quaternary ammonium group transport	IDA Inferred from Direct Assay more info	PubMed
involved_in quaternary ammonium group transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within quaternary ammonium group transport	ISO Inferred from Sequence Orthology more info
involved_in quaternary ammonium group transport	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info
involved_in triglyceride metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within triglyceride metabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic transport	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in basal plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: solute carrier family 22 member 4

Names: organic cation transporter OCTN1; organic cation/carnitine transporter 1; solute carrier family 22 (organic cation transporter), member 4; solute carrier family 22 (organic cation/zwitterion transporter), member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022270.2 → NP_071606.1 solute carrier family 22 member 4

See identical proteins and their annotated locations for NP_071606.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q9R141

UniProtKB/TrEMBL

A6HEF8

Related

ENSRNOP00000055693.5, ENSRNOT00000058907.5

Conserved Domains (1) summary

TIGR00898
Location:12 → 519

2A0119; cation transport protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

38634098..38687409 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039086773.2 → XP_038942701.1 solute carrier family 22 member 4 isoform X2

Conserved Domains (1) summary

TIGR00898
Location:12 → 427

2A0119; cation transport protein
XM_039086772.2 → XP_038942700.1 solute carrier family 22 member 4 isoform X1

UniProtKB/TrEMBL

D3ZCM6

Conserved Domains (1) summary

TIGR00898
Location:12 → 458

2A0119; cation transport protein
XM_039086777.2 → XP_038942705.1 solute carrier family 22 member 4 isoform X4

UniProtKB/TrEMBL

A6HEF9, A6HEG0

Conserved Domains (1) summary

cl28910
Location:1 → 334

MFS; Major Facilitator Superfamily
XM_039086775.2 → XP_038942703.1 solute carrier family 22 member 4 isoform X4

UniProtKB/TrEMBL

A6HEF9, A6HEG0

Conserved Domains (1) summary

cl28910
Location:1 → 334

MFS; Major Facilitator Superfamily
XM_063269796.1 → XP_063125866.1 solute carrier family 22 member 4 isoform X3
XM_039086776.2 → XP_038942704.1 solute carrier family 22 member 4 isoform X4

UniProtKB/TrEMBL

A6HEF9, A6HEG0

Conserved Domains (1) summary

cl28910
Location:1 → 334

MFS; Major Facilitator Superfamily