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    Cnn2 calponin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 690976, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Cnn2provided by RGD
    Official Full Name
    calponin 2provided by RGD
    Primary source
    RGD:1589807
    See related
    AllianceGenome:RGD:1589807
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin binding activity and calmodulin binding activity. Predicted to be involved in actomyosin structure organization. Predicted to act upstream of or within several processes, including cellular response to mechanical stimulus; negative regulation of phagocytosis; and wound healing. Predicted to be located in stress fiber. Predicted to be active in cytoskeleton. Orthologous to human CNN2 (calponin 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 622.3), Thymus (RPKM 508.2) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cnn2 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10363141..10370312, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9712505..9719678, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12782459..12787977)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 45 Neighboring gene ATP binding cassette subfamily A member 7 Neighboring gene uncharacterized LOC134479813 Neighboring gene U6 spliceosomal RNA Neighboring gene transmembrane protein 259 Neighboring gene glutamate ionotropic receptor NMDA type subunit 3B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Role of H2-calponin in regulating macrophage motility and phagocytosis. Huang QQ, et al. J Biol Chem, 2008 Sep 19. PMID 18617524, Free PMC Article
    2. h2-Calponin is regulated by mechanical tension and modifies the function of actin cytoskeleton. Hossain MM, et al. J Biol Chem, 2005 Dec 23. PMID 16236705, Free PMC Article
    3. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Kuo JC, et al. Nat Cell Biol, 2011 Apr. PMID 21423176, Free PMC Article
    4. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article
    5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actomyosin structure organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to mechanical stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of establishment of localization in cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of macrophage migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of macrophage migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of phagocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of phagocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of actin filament-based process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of leukocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of mononuclear cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within wound healing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    calponin-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399010.1 → NP_001385939.1  calponin-2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      Conserved Domains (2) summary
      pfam00402
      Location:166 → 190
      Calponin; Calponin family repeat
      cd21283
      Location:27 → 135
      CH_CNN2; calponin homology (CH) domain found in calponin-2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      10363141..10370312 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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