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    Rab11fip3 RAB11 family interacting protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303002, updated on 2-May-2024

    Summary

    Official Symbol
    Rab11fip3provided by RGD
    Official Full Name
    RAB11 family interacting protein 3provided by RGD
    Primary source
    RGD:1308952
    See related
    Ensembl:ENSRNOG00000032152 AllianceGenome:RGD:1308952
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    LRRGT00043; RGD1308952
    Summary
    Predicted to enable dynein light intermediate chain binding activity; protein homodimerization activity; and small GTPase binding activity. Predicted to be involved in endocytic recycling; negative regulation of adiponectin secretion; and regulation of cytokinesis. Predicted to act upstream of or within protein localization to cilium. Predicted to be located in several cellular components, including centriolar satellite; intercellular bridge; and recycling endosome. Predicted to be active in cleavage furrow; cytoplasmic vesicle; and midbody. Orthologous to human RAB11FIP3 (RAB11 family interacting protein 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 349.4), Brain (RPKM 75.3) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rab11fip3 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (15507151..15591173, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (15002650..15086382, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (15348356..15433384, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L36A, pseudogene 7 Neighboring gene calpain 15 Neighboring gene uncharacterized LOC120095052 Neighboring gene uncharacterized LOC134480764 Neighboring gene 60S ribosomal protein L34 pseudogene Neighboring gene ribosomal protein L37A, pseudogene 10 Neighboring gene ribosomal protein L3, pseudogene 2 Neighboring gene 2,4-dienoyl-CoA reductase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 2,4-dienoyl-CoA reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables dynein light intermediate chain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleoside diphosphate kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in CTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in GTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Golgi to plasma membrane protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in UTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in early endosome to recycling endosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in endocytic recycling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fatty acid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of adiponectin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitotic cytokinetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein localization to cilium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to cilium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of early endosome to recycling endosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of endocytic recycling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein localization to centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cleavage furrow IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endocytic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in midbody IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic recycling endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in recycling endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in trans-Golgi network membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    rab11 family-interacting protein 3
    Names
    RAB11 family interacting protein 3 (class II)
    eferin
    NP_001414014.1
    XP_002727801.1
    XP_006246133.1
    XP_038943046.1
    XP_063125014.1
    XP_063125015.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427085.1NP_001414014.1  rab11 family-interacting protein 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6GLH8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      15507151..15591173 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246071.4XP_006246133.1  rab11 family-interacting protein 3 isoform X2

      See identical proteins and their annotated locations for XP_006246133.1

      UniProtKB/TrEMBL
      A0A8I5ZUA1
      Related
      ENSRNOP00000082618.1
      Conserved Domains (7) summary
      cd00051
      Location:516573
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam09457
      Location:10131053
      RBD-FIP; FIP domain
      pfam05700
      Location:776886
      BCAS2; Breast carcinoma amplified sequence 2 (BCAS2)
      pfam07926
      Location:837985
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      pfam13499
      Location:517573
      EF-hand_7; EF-hand domain pair
      pfam14077
      Location:944987
      WD40_alt; Alternative WD40 repeat motif
      cl00143
      Location:837939
      SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
    2. XM_002727755.6XP_002727801.1  rab11 family-interacting protein 3 isoform X1

      See identical proteins and their annotated locations for XP_002727801.1

      UniProtKB/TrEMBL
      A0A8I5ZQX0
      Related
      ENSRNOP00000080945.1
      Conserved Domains (7) summary
      cd00051
      Location:516573
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam09457
      Location:10251065
      RBD-FIP; FIP domain
      pfam05700
      Location:788898
      BCAS2; Breast carcinoma amplified sequence 2 (BCAS2)
      pfam07926
      Location:849997
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      pfam13499
      Location:517573
      EF-hand_7; EF-hand domain pair
      pfam14077
      Location:956999
      WD40_alt; Alternative WD40 repeat motif
      cl00143
      Location:849951
      SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
    3. XM_063268945.1XP_063125015.1  rab11 family-interacting protein 3 isoform X5

      UniProtKB/TrEMBL
      Q66H66
    4. XM_063268944.1XP_063125014.1  rab11 family-interacting protein 3 isoform X3

    5. XM_039087118.2XP_038943046.1  rab11 family-interacting protein 3 isoform X4

      Conserved Domains (2) summary
      PTZ00449
      Location:12328
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam13405
      Location:516545
      EF-hand_6; EF-hand domain