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    Rhobtb2 Rho-related BTB domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306004, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Rhobtb2provided by RGD
    Official Full Name
    Rho-related BTB domain containing 2provided by RGD
    Primary source
    RGD:1309924
    See related
    Ensembl:ENSRNOG00000017373 AllianceGenome:RGD:1309924
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including cytoskeleton organization; engulfment of apoptotic cell; and regulation of cell shape. Predicted to be active in several cellular components, including cell cortex; cytoplasmic vesicle; and cytoskeleton. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy. Orthologous to human RHOBTB2 (Rho related BTB domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 82.2), Adrenal (RPKM 50.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rhobtb2 in Genome Data Viewer
    Location:
    15p11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (51278024..51298209, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (44868251..44888436, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (51465148..51485562, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene R3H domain and coiled-coil containing 1 Neighboring gene charged multivesicular body protein 7 Neighboring gene TNF receptor superfamily member 10b Neighboring gene uncharacterized LOC103693695 Neighboring gene uncharacterized LOC102550955

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109268

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Cdc42 protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment or maintenance of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    rho-related BTB domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013133.1 → NP_001013151.1  rho-related BTB domain-containing protein 2

      See identical proteins and their annotated locations for NP_001013151.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091309
      UniProtKB/TrEMBL
      A6HTI2, Q5BJV7
      Related
      ENSRNOP00000088428.1, ENSRNOT00000117351.1
      Conserved Domains (4) summary
      cd01873
      Location:13 → 207
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      cd18359
      Location:480 → 603
      BTB2_POZ_RHOBTB2; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2)
      cd18531
      Location:608 → 704
      BACK_RHOBTB2; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2)
      cl38908
      Location:250 → 475
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      51278024..51298209 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274298.1 → XP_063130368.1  rho-related BTB domain-containing protein 2 isoform X2

    2. XM_017599699.3 → XP_017455188.2  rho-related BTB domain-containing protein 2 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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