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    Pgap6 post-GPI attachment to proteins 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303004, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Pgap6provided by RGD
    Official Full Name
    post-GPI attachment to proteins 6provided by RGD
    Primary source
    RGD:1311395
    See related
    Ensembl:ENSRNOG00000020374 AllianceGenome:RGD:1311395
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    M83; Tmem8; Tmem8a
    Summary
    Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Orthologous to human PGAP6 (post-glycosylphosphatidylinositol attachment to proteins 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 169.3), Testes (RPKM 28.1) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pgap6 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (15643081..15652912)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (15138918..15148431)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (15484952..15495380)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L34-like Neighboring gene NME/NM23 nucleoside diphosphate kinase 4 Neighboring gene mitochondrial ribosomal protein L28 Neighboring gene axin 1 Neighboring gene U6atac minor spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Integral and associated lysosomal membrane proteins. Schröder B, et al. Traffic, 2007 Dec. PMID 17897319
    2. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    post-GPI attachment to proteins factor 6
    Names
    post-glycosylphosphatidylinositol attachment to proteins 6
    transmembrane protein 8 (five membrane-spanning domains)
    transmembrane protein 8A
    type I transmembrane protein
    NP_001100461.1
    XP_063125016.1
    XP_063125017.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106991.1 → NP_001100461.1  post-GPI attachment to proteins factor 6 precursor

      See identical proteins and their annotated locations for NP_001100461.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A0A0G2JV00, A6HD88, D3ZKI8
      Related
      ENSRNOP00000027609.4, ENSRNOT00000027609.6
      Conserved Domains (1) summary
      pfam12036
      Location:553 → 728
      DUF3522; Protein of unknown function (DUF3522)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      15643081..15652912
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268946.1 → XP_063125016.1  post-GPI attachment to proteins factor 6 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZVT8

    2. XM_063268947.1 → XP_063125017.1  post-GPI attachment to proteins factor 6 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZVT8

    RNA

    1. XR_010055170.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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