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    Taf3 TATA-box binding protein associated factor 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100360100, updated on 2-May-2024

    Summary

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    Official Symbol
    Taf3provided by RGD
    Official Full Name
    TATA-box binding protein associated factor 3provided by RGD
    Primary source
    RGD:2324594
    See related
    Ensembl:ENSRNOG00000019223 AllianceGenome:RGD:2324594
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable p53 binding activity and transcription regulator inhibitor activity. Predicted to be involved in maintenance of protein location in nucleus; negative regulation of DNA-binding transcription factor activity; and negative regulation of transcription by RNA polymerase II. Predicted to be located in nuclear membrane and nucleoplasm. Predicted to be part of transcription factor TFIID complex. Orthologous to human TAF3 (TATA-box binding protein associated factor 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 34.1), Kidney (RPKM 30.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Taf3 in Genome Data Viewer
    Location:
    17q12.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (73365162..73518053)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (68455389..68608367)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (72240785..72393448)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC102546431 Neighboring gene ATP synthase F1 subunit gamma Neighboring gene Kin17 DNA and RNA binding protein Neighboring gene uncharacterized LOC120097843 Neighboring gene GATA binding protein 3 Neighboring gene uncharacterized LOC134482600

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function. Bereczki O, et al. BMC Mol Biol, 2008 Jun 12. PMID 18549481, Free PMC Article
    2. The nuclear import of TAF10 is regulated by one of its three histone fold domain-containing interaction partners. Soutoglou E, et al. Mol Cell Biol, 2005 May. PMID 15870280, Free PMC Article
    3. Structural bioinformatics of the general transcription factor TFIID. Malkowska M, et al. Biochimie, 2013 Apr. PMID 23146842
    4. The TFIID components human TAF(II)140 and Drosophila BIP2 (TAF(II)155) are novel metazoan homologues of yeast TAF(II)47 containing a histone fold and a PHD finger. Gangloff YG, et al. Mol Cell Biol, 2001 Aug. PMID 11438666, Free PMC Article
    5. The intracellular localisation of TAF7L, a paralogue of transcription factor TFIID subunit TAF7, is developmentally regulated during male germ-cell differentiation. Pointud JC, et al. J Cell Sci, 2003 May 1. PMID 12665565

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proton-transporting ATP synthase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription regulator inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA polymerase II preinitiation complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mRNA transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in maintenance of protein location in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription initiation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proton motive force-driven ATP synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in male germ cell nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proton-transporting ATP synthase complex, catalytic core F(1) IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIID complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transcription initiation factor TFIID subunit 3
    Names
    TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271342.1 → NP_001258271.1  transcription initiation factor TFIID subunit 3

      See identical proteins and their annotated locations for NP_001258271.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A6JLU9, D3ZPB7
      Related
      ENSRNOP00000068697.1, ENSRNOT00000090453.2
      Conserved Domains (3) summary
      smart00576
      Location:5 → 79
      BTP; Bromodomain transcription factors and PHD domain containing proteins
      cd15522
      Location:867 → 912
      PHD_TAF3; PHD finger found in transcription initiation factor TFIID subunit 3 (TAF3)
      pfam16294
      Location:596 → 654
      RSB_motif; RNSP1-SAP18 binding (RSB) motif

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      73365162..73518053
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254228.5 → XP_006254290.1  transcription initiation factor TFIID subunit 3 isoform X1

      See identical proteins and their annotated locations for XP_006254290.1

      UniProtKB/TrEMBL
      A6JLU9, D3ZPB7
      Conserved Domains (3) summary
      smart00576
      Location:5 → 79
      BTP; Bromodomain transcription factors and PHD domain containing proteins
      cd15522
      Location:867 → 912
      PHD_TAF3; PHD finger found in transcription initiation factor TFIID subunit 3 (TAF3)
      pfam16294
      Location:596 → 654
      RSB_motif; RNSP1-SAP18 binding (RSB) motif
    Nucleotide Protein Strain
    Heading Accession and Version

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