Ripk1 receptor interacting serine/threonine kinase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ripk1provided by RGD
Official Full Name: receptor interacting serine/threonine kinase 1provided by RGD
Primary source: RGD:1310158
See related: Ensembl:ENSRNOG00000017787 AllianceGenome:RGD:1310158
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables death receptor binding activity. Involved in positive regulation of necroptotic process. Located in membrane raft. Part of protein-containing complex. Human ortholog(s) of this gene implicated in immunodeficiency 57. Orthologous to human RIPK1 (receptor interacting serine/threonine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 117.7), Lung (RPKM 117.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p12

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (31044983..31077167, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (30839639..30871824, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (31537580..31569904, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TAK1 Reduces Surgery-induced Overactivation of RIPK1 to Relieve Neuroinflammation and Cognitive Dysfunction in Aged Rats.
Title: TAK1 Reduces Surgery-induced Overactivation of RIPK1 to Relieve Neuroinflammation and Cognitive Dysfunction in Aged Rats.
RIPK1-RIPK3 mediates myocardial fibrosis in type 2 diabetes mellitus by impairing autophagic flux of cardiac fibroblasts.
Title: RIPK1-RIPK3 mediates myocardial fibrosis in type 2 diabetes mellitus by impairing autophagic flux of cardiac fibroblasts.
TNF-alpha-Mediated RIPK1 Pathway Participates in the Development of Trigeminal Neuropathic Pain in Rats.
Title: TNF-α-Mediated RIPK1 Pathway Participates in the Development of Trigeminal Neuropathic Pain in Rats.
Effects of 17-AAG on the RIP1/RIP3/MLKL pathway during the development of heart failure following myocardial infarction in rats.
Title: Effects of 17-AAG on the RIP1/RIP3/MLKL pathway during the development of heart failure following myocardial infarction in rats.
Overexpressed microRNA-494 represses RIPK1 to attenuate hippocampal neuron injury in epilepsy rats by inactivating the NF-kappaB signaling pathway.
Title: Overexpressed microRNA-494 represses RIPK1 to attenuate hippocampal neuron injury in epilepsy rats by inactivating the NF-κB signaling pathway.
Heat stress induces RIP1/RIP3-dependent necroptosis through the MAPK, NF-kappaB, and c-Jun signaling pathways in pulmonary vascular endothelial cells.
Title: Heat stress induces RIP1/RIP3-dependent necroptosis through the MAPK, NF-κB, and c-Jun signaling pathways in pulmonary vascular endothelial cells.
Ischemia induces an up-regulation of RIP1K and an enhancement of RIP1K-RIP3K complex formation in neurons and astrocytes. Inhibition of RIP1K increases ischemia-induced reduction in MAP2 or GFAP and decreases ischemia-induced neuronal or astrocytic cell necrosis in the ischemic cortex, and directly protects OGD-induced neuronal or astrocytic cell death. Nec-1 blocks RIP1K-RIP3K complex formation.
Title: RIP1K Contributes to Neuronal and Astrocytic Cell Death in Ischemic Stroke via Activating Autophagic-lysosomal Pathway.
RIPK1/RIPK3/MLKL-mediated necroptosis may play an important role in nucleus pulposus (NP) cell death induced by continuous mechanical stress. Treatment strategies which aim to regulate necroptosis may prove beneficial, by both reducing NP cells death and slowing IVD degeneration.
Title: RIPK1/RIPK3/MLKL-mediated necroptosis contributes to compression-induced rat nucleus pulposus cells death.
Shikonin induces glioma cell necroptosis in vitro by reactive oxygen species overproduction and promoting RIP1/RIP3 necrosome formation.
Title: Shikonin induces glioma cell necroptosis in vitro by ROS overproduction and promoting RIP1/RIP3 necrosome formation.
This is demonstrated that mild-induced hypothermia treatment significantly reduced RIPK-1 upregulation, which may inhibit necroptosis and apoptosis pathways after moderate traumatic brain injury.
Title: Protective effect of mild-induced hypothermia against moderate traumatic brain injury in rats involved in necroptotic and apoptotic pathways.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH141522 (e-PCR)
- UniSTS:223516

RH134680 (e-PCR)
- UniSTS:217959

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables JUN kinase kinase kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables death domain binding	ISO Inferred from Sequence Orthology more info
enables death receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables death receptor binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables signaling adaptor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in T cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in T cell apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in amyloid fibril formation	ISO Inferred from Sequence Orthology more info
involved_in amyloid fibril formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within necroptotic process	ISO Inferred from Sequence Orthology more info
involved_in necroptotic process	ISO Inferred from Sequence Orthology more info
involved_in necroptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in necroptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in necroptotic signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of necroptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of execution phase of apoptosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of miRNA processing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of necroptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of necroptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of non-canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of programmed cell death	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of programmed necrotic cell death	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in programmed necrotic cell death	ISO Inferred from Sequence Orthology more info
involved_in protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in ripoptosome assembly	ISO Inferred from Sequence Orthology more info
involved_in ripoptosome assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within ripoptosome assembly involved in necroptotic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of death-inducing signaling complex	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info
part_of ripoptosome	ISO Inferred from Sequence Orthology more info
part_of ripoptosome	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: receptor-interacting serine/threonine-protein kinase 1

Names: RIP; receptor (TNFRSF)-interacting serine-threonine kinase 1

NP_001100820.1

EC 2.7.11.1

XP_017456015.1

EC 2.7.11.1

XP_017456017.1

EC 2.7.11.1

XP_017456018.1

EC 2.7.11.1

XP_038951624.1

EC 2.7.11.1

XP_063132480.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107350.1 → NP_001100820.1 receptor-interacting serine/threonine-protein kinase 1

See identical proteins and their annotated locations for NP_001100820.1

Status: PROVISIONAL

Source sequence(s)

CH473977

UniProtKB/TrEMBL

A6J7H3, D3ZYL0

Related

ENSRNOP00000023962.4, ENSRNOT00000023962.6

Conserved Domains (2) summary

cd08777
Location:570 → 655

Death_RIP1; Death Domain of Receptor-Interacting Protein 1

cl21453
Location:23 → 290

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

31044983..31077167 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017600528.3 → XP_017456017.1 receptor-interacting serine/threonine-protein kinase 1 isoform X1

UniProtKB/TrEMBL

A6J7H3, D3ZYL0

Conserved Domains (2) summary

cd08777
Location:570 → 655

Death_RIP1; Death Domain of Receptor-Interacting Protein 1

cl21453
Location:23 → 290

PKc_like; Protein Kinases, catalytic domain
XM_017600529.2 → XP_017456018.1 receptor-interacting serine/threonine-protein kinase 1 isoform X1

UniProtKB/TrEMBL

A6J7H3, D3ZYL0

Conserved Domains (2) summary

cd08777
Location:570 → 655

Death_RIP1; Death Domain of Receptor-Interacting Protein 1

cl21453
Location:23 → 290

PKc_like; Protein Kinases, catalytic domain
XM_017600526.2 → XP_017456015.1 receptor-interacting serine/threonine-protein kinase 1 isoform X1

UniProtKB/TrEMBL

A6J7H3, D3ZYL0

Conserved Domains (2) summary

cd08777
Location:570 → 655

Death_RIP1; Death Domain of Receptor-Interacting Protein 1

cl21453
Location:23 → 290

PKc_like; Protein Kinases, catalytic domain
XM_063276410.1 → XP_063132480.1 receptor-interacting serine/threonine-protein kinase 1 isoform X1

UniProtKB/TrEMBL

A6J7H3, D3ZYL0
XM_039095696.1 → XP_038951624.1 receptor-interacting serine/threonine-protein kinase 1 isoform X2

Conserved Domains (2) summary

cd08777
Location:378 → 463

Death_RIP1; Death Domain of Receptor-Interacting Protein 1

cl21453
Location:1 → 98

PKc_like; Protein Kinases, catalytic domain