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    ESF2 RNA-binding ATPase activator ESF2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855790, updated on 17-May-2024

    Summary

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    Gene symbol
    ESF2
    Gene description
    RNA-binding ATPase activator ESF2
    Primary source
    FungiDB:YNR054C
    Locus tag
    YNR054C
    See related
    SGD:S000005337; AllianceGenome:SGD:S000005337
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ABT1
    Summary
    Enables ATPase activator activity and RNA binding activity. Involved in ribosomal small subunit biogenesis. Located in nucleolus. Orthologous to human ABT1 (activator of basal transcription 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ESF2 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (723356..724306, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene CCR4-NOT core DEDD family RNase subunit POP2 Neighboring gene putative GTPase NOG2 Neighboring gene ncRNA Neighboring gene tRNA-Leu Neighboring gene Hol1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The nucleolar protein Esf2 interacts directly with the DExD/H box RNA helicase, Dbp8, to stimulate ATP hydrolysis. Granneman S, et al. Nucleic Acids Res, 2006. PMID 16772403, Free PMC Article
    2. A novel TATA-binding protein-binding protein, ABT1, activates basal transcription and has a yeast homolog that is essential for growth. Oda T, et al. Mol Cell Biol, 2000 Feb. PMID 10648625, Free PMC Article
    3. Esf2p, a U3-associated factor required for small-subunit processome assembly and compaction. Hoang T, et al. Mol Cell Biol, 2005 Jul. PMID 15964808, Free PMC Article
    4. Pwp2 mediates UTP-B assembly via two structurally independent domains. Boissier F, et al. Sci Rep, 2017 Jun 9. PMID 28600509, Free PMC Article
    5. The SSU processome interactome in Saccharomyces cerevisiae reveals novel protein subcomplexes. Vincent NG, et al. RNA, 2018 Jan. PMID 29054886, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in small-subunit processome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in small-subunit processome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in nucleolus HDA PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding ATPase activator ESF2
    NP_014452.1
    • Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      723356..724306 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183231.1 → NP_014452.1  TPA: RNA-binding ATPase activator ESF2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014452.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1M9, P53743
      UniProtKB/TrEMBL
      A0A8H4BWZ1, A6ZSC8, B3LPI9, B5VR79, C7GLK3, C8ZFT3, N1NY94
      Conserved Domains (1) summary
      cd12263
      Location:114 → 211
      RRM_ABT1_like; RNA recognition motif (RRM) found in activator of basal transcription 1 (ABT1) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53743.1

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