Mybl1 myeloblastosis oncogene-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mybl1provided by MGI
Official Full Name: myeloblastosis oncogene-like 1provided by MGI
Primary source: MGI:MGI:99925
See related: Ensembl:ENSMUSG00000025912 AllianceGenome:MGI:99925
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A-myb; repro9; G1-419-6
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in several processes, including male gamete generation; negative regulation of transposition; and piRNA biosynthetic process. Located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system gland; and sensory organ. Orthologous to human MYBL1 (MYB proto-oncogene like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E11.5 (RPKM 1.8), testis adult (RPKM 1.4) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 A2; 1 2.08 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (9737632..9770664, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (9667407..9700439, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LncRNA ENSMUST00000171502 Induced by HIF-1alpha Ameliorates Ischemic Acute Kidney Injury via Targeting the miR-130b-3p/Mybl-1 Axis.
Title: LncRNA ENSMUST00000171502 Induced by HIF-1α Ameliorates Ischemic Acute Kidney Injury via Targeting the miR-130b-3p/Mybl-1 Axis.
LncRNA-Gm2044 is transcriptionally activated by A-MYB and regulates Sycp1 expression as a miR-335-3p sponge in mouse spermatocyte-derived GC-2spd(ts) cells.
Title: LncRNA-Gm2044 is transcriptionally activated by A-MYB and regulates Sycp1 expression as a miR-335-3p sponge in mouse spermatocyte-derived GC-2spd(ts) cells.
Super-enhancer switching drives a burst in gene expression at the mitosis-to-meiosis transition.
Title: Super-enhancer switching drives a burst in gene expression at the mitosis-to-meiosis transition.
A-MYB regulation of piRNA pathway proteins and piRNA genes creates a coherent feedforward loop that ensures the robust accumulation of pachytene piRNAs during early meiosis in mouse testes.
Title: An ancient transcription factor initiates the burst of piRNA production during early meiosis in mouse testes.
A-MYB (MYBL1) stimulates murine testis-specific Ldhc expression via the cAMP-responsive element (CRE) site.
Title: A-MYB (MYBL1) stimulates murine testis-specific Ldhc expression via the cAMP-responsive element (CRE) site.
Results reveal that MYBL1 is a master regulator of meiotic genes that are involved in multiple processes in spermatocytes, particularly those required for cell cycle progression through pachynema.
Title: A-MYB (MYBL1) transcription factor is a master regulator of male meiosis.
RFX2 is potentially an important transcriptional regulator in pachytene spermatocytes; Rfx2 itself is a good candidate to be regulated by A-MYB, which is essential for meiotic progression.
Title: RFX2 is a candidate downstream amplifier of A-MYB regulation in mouse spermatogenesis.
A-myb plays a role in the reactive gliosis signaling pathway in kainic acid-induced excitotoxic lesions
Title: Induction of transcription factor A-myb expression in reactive astrocytes following an excitotoxic lesion in the mouse hippocampus.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (2)
Targeted (2) 1 citation

General gene information

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Markers

Mybl1 (e-PCR), detects polymorphism
- UniSTS:547269

L35261 (e-PCR)
- UniSTS:124903

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables promoter-specific chromatin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in male meiosis I	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of piRNA transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_positive_effect siRNA-mediated retrotransposon silencing by heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: myb-related protein A

Names: myb-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290397.1 → NP_001277326.1 myb-related protein A isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.

Source sequence(s)

AC103620, AC158790

Consensus CDS

CCDS69861.1

UniProtKB/TrEMBL

E9QLX9, Q3ZB50

Related

ENSMUSP00000111128.3, ENSMUST00000115468.9

Conserved Domains (4) summary

smart00717
Location:87 → 135

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam00249
Location:87 → 133

Myb_DNA-binding; Myb-like DNA-binding domain

pfam07988
Location:242 → 285

LMSTEN; LMSTEN motif

pfam09316
Location:485 → 646

Cmyb_C; C-myb, C-terminal
NM_008651.3 → NP_032677.2 myb-related protein A isoform 1

See identical proteins and their annotated locations for NP_032677.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC103620, AC158790

Consensus CDS

CCDS35510.1

UniProtKB/TrEMBL

A0A0R4J132, Q3ZB50

Related

ENSMUSP00000086034.5, ENSMUST00000088658.11

Conserved Domains (4) summary

smart00717
Location:87 → 135

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam00249
Location:87 → 133

Myb_DNA-binding; Myb-like DNA-binding domain

pfam07988
Location:242 → 285

LMSTEN; LMSTEN motif

pfam09316
Location:485 → 646

Cmyb_C; C-myb, C-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

9737632..9770664 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006495461.1 → XP_006495524.1 myb-related protein A isoform X1

UniProtKB/TrEMBL

Q3ZB50

Conserved Domains (3) summary

PLN03091
Location:84 → 192

PLN03091; hypothetical protein; Provisional

pfam09316
Location:450 → 609

Cmyb_C; C-myb, C-terminal

pfam13921
Location:38 → 98

Myb_DNA-bind_6; Myb-like DNA-binding domain
XM_011238350.2 → XP_011236652.1 myb-related protein A isoform X3

Conserved Domains (1) summary

pfam09316
Location:211 → 370

Cmyb_C; C-myb, C-terminal
XM_011238349.3 → XP_011236651.1 myb-related protein A isoform X2

UniProtKB/TrEMBL

Q3ZB50

Conserved Domains (4) summary

PLN03091
Location:84 → 192

PLN03091; hypothetical protein; Provisional

pfam07988
Location:242 → 285

LMSTEN; LMSTEN motif

pfam09316
Location:485 → 644

Cmyb_C; C-myb, C-terminal

pfam13921
Location:38 → 98

Myb_DNA-bind_6; Myb-like DNA-binding domain