Usp20 ubiquitin specific peptidase 20 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Usp20provided by MGI
Official Full Name: ubiquitin specific peptidase 20provided by MGI
Primary source: MGI:MGI:1921520
See related: Ensembl:ENSMUSG00000026854 AllianceGenome:MGI:1921520
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Vdu2; 1700055M05Rik
Summary: Predicted to enable G protein-coupled receptor binding activity; cysteine-type endopeptidase activity; and thiol-dependent deubiquitinase. Predicted to be involved in protein K48-linked deubiquitination; protein K63-linked deubiquitination; and regulation of G protein-coupled receptor signaling pathway. Predicted to act upstream of or within endocytosis and proteolysis. Predicted to be located in centrosome. Predicted to be active in cytoplasm. Is expressed in ganglia; retina; and trigeminal nerve. Orthologous to human USP20 (ubiquitin specific peptidase 20). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 28.5), genital fat pad adult (RPKM 18.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 B; 2 21.77 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (30872291..30912667)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (30982279..31022655)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A novel PDIA3/FTO/USP20 positive feedback regulatory loop induces osteogenic differentiation of preosteoblast in osteoporosis.
Title: A novel PDIA3/FTO/USP20 positive feedback regulatory loop induces osteogenic differentiation of preosteoblast in osteoporosis.
Phosphorylation of USP20 on Ser334 by IRAK1 promotes IL-1beta-evoked signaling in vascular smooth muscle cells and vascular inflammation.
Title: Phosphorylation of USP20 on Ser334 by IRAK1 promotes IL-1β-evoked signaling in vascular smooth muscle cells and vascular inflammation.
Sleeve gastrectomy improves lipid dysmetabolism by downregulating the USP20-HSPA2 axis in diet-induced obese mice.
Title: Sleeve gastrectomy improves lipid dysmetabolism by downregulating the USP20-HSPA2 axis in diet-induced obese mice.
USP20 links feeding-induced cholesterol synthesis and energy expenditure.
Title: USP20 links feeding-induced cholesterol synthesis and energy expenditure.
Feeding induces cholesterol biosynthesis via the mTORC1-USP20-HMGCR axis.
Title: Feeding induces cholesterol biosynthesis via the mTORC1-USP20-HMGCR axis.
These findings suggest a crucial role of USP20 in maintaining the stability of MITA and promoting innate antiviral signaling.
Title: USP20 Promotes Cellular Antiviral Responses via Deconjugating K48-Linked Ubiquitination of MITA.
USP20 attenuates TNF- and IL-1beta-evoked atherogenic signaling in smooth muscle cells, by deubiquitinating RIPK1, among other signaling intermediates.
Title: USP20 (Ubiquitin-Specific Protease 20) Inhibits TNF (Tumor Necrosis Factor)-Triggered Smooth Muscle Cell Inflammation and Attenuates Atherosclerosis.
USP20 regulates beta1AR signaling in vitro and in vivo Additionally, beta1AR-induced USP20 phosphorylation may serve as a feed-forward mechanism to stabilize beta1AR expression and signaling during pathological insults to the myocardium.
Title: The deubiquitinase ubiquitin-specific protease 20 is a positive modulator of myocardial β(1)-adrenergic receptor expression and signaling.
that pro- and anti-inflammatory activities of beta-arrestin2 are determined by beta-arrestin2 ubiquitination and that changes in USP20 expression and/or activity can therefore regulate inflammatory responses
Title: Ubiquitin-specific Protease 20 Regulates the Reciprocal Functions of β-Arrestin2 in Toll-like Receptor 4-promoted Nuclear Factor κB (NFκB) Activation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (8) 1 citation
Gene trapped (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH135207 (e-PCR)
- UniSTS:218484

NoName (e-PCR)
- UniSTS:234360

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	ISO Inferred from Sequence Orthology more info
enables cysteine-type deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in antiviral innate immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endocytosis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein deubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ubiquitin carboxyl-terminal hydrolase 20

Names: VHL-interacting deubiquitinating enzyme 2; deubiquitinating enzyme 20; ubiquitin specific protease 20; ubiquitin thioesterase 20; ubiquitin thiolesterase 20; ubiquitin-specific-processing protease 20

NP_083122.1

EC 3.4.19.12

XP_030107995.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028846.5 → NP_083122.1 ubiquitin carboxyl-terminal hydrolase 20

See identical proteins and their annotated locations for NP_083122.1

Status: VALIDATED

Source sequence(s)

AK047242, AK054279, AK173083, BY251374

Consensus CDS

CCDS15893.1

UniProtKB/Swiss-Prot

Q69ZT5, Q8C6M1, Q8CJ72

Related

ENSMUSP00000099913.5, ENSMUST00000102849.11

Conserved Domains (4) summary

smart00695
Location:812 → 896

DUSP; Domain in ubiquitin-specific proteases

COG5560
Location:73 → 688

UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

pfam00443
Location:145 → 684

UCH; Ubiquitin carboxyl-terminal hydrolase

pfam02148
Location:30 → 90

zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

30872291..30912667

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030252135.1 → XP_030107995.1 ubiquitin carboxyl-terminal hydrolase 20 isoform X1

UniProtKB/Swiss-Prot

Q69ZT5, Q8C6M1, Q8CJ72

Conserved Domains (4) summary

smart00695
Location:812 → 896

DUSP; Domain in ubiquitin-specific proteases

COG5560
Location:73 → 688

UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

pfam00443
Location:145 → 684

UCH; Ubiquitin carboxyl-terminal hydrolase

pfam02148
Location:30 → 90

zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein