Ccnb1 cyclin B1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccnb1provided by MGI
Official Full Name: cyclin B1provided by MGI
Primary source: MGI:MGI:88302
See related: Ensembl:ENSMUSG00000041431 AllianceGenome:MGI:88302
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CycB1; Cycb-4; Cycb-5; Ccnb1-rs1; Cycb1-rs1; Ccnb1-rs13
Summary: Predicted to enable cyclin-dependent protein serine/threonine kinase activator activity; enzyme binding activity; and patched binding activity. Acts upstream of or within several processes, including histone H3-S10 phosphorylation involved in chromosome condensation; in utero embryonic development; and positive regulation of fibroblast proliferation. Located in cytoplasm; membrane; and nucleus. Colocalizes with mitochondrial matrix. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; eye; and genitourinary system. Human ortholog(s) of this gene implicated in breast cancer and prostate cancer. Orthologous to human CCNB1 (cyclin B1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E14 (RPKM 79.4), liver E14.5 (RPKM 71.8) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 D1; 13 53.23 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (100915247..100922994, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (100778739..100786486, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kielin/chordin-like protein deficiency aggravates pressure overload-induced cardiac dysfunction and remodeling via P53/P21/CCNB1 signaling in mice.
Title: Kielin/chordin-like protein deficiency aggravates pressure overload-induced cardiac dysfunction and remodeling via P53/P21/CCNB1 signaling in mice.
Alternative cleavage and polyadenylation of the Ccnb1 mRNA defines accumulation of cyclin protein during the meiotic cell cycle.
Title: Alternative cleavage and polyadenylation of the Ccnb1 mRNA defines accumulation of cyclin protein during the meiotic cell cycle.
Septin 9 controls CCNB1 stabilization via APC/C[CDC20] during meiotic metaphase I/anaphase I transition in mouse oocytes.
Title: Septin 9 controls CCNB1 stabilization via APC/C(CDC20) during meiotic metaphase I/anaphase I transition in mouse oocytes.
Knockout of cyclin B1 in granulosa cells causes female subfertility.
Title: Knockout of cyclin B1 in granulosa cells causes female subfertility.
Single Molecule RNA Localization and Translation in the Mammalian Oocyte and Embryo.
Title: Single Molecule RNA Localization and Translation in the Mammalian Oocyte and Embryo.
5'-UTR and ORF elements, as well as the 3'-UTR regulate the translation of Cyclin.
Title: 5'-UTR and ORF elements, as well as the 3'-UTR regulate the translation of Cyclin.
Mis12 controls cyclin B1 stabilization via Cdc14B-mediated APC/C(Cdh1) regulation during meiotic G2/M transition in mouse oocytes.
Title: Mis12 controls cyclin B1 stabilization via Cdc14B-mediated APC/C(Cdh1) regulation during meiotic G2/M transition in mouse oocytes.
CYCLIN-B1/2 and -D1 act in opposition to coordinate cortical progenitor self-renewal and lineage commitment.
Title: CYCLIN-B1/2 and -D1 act in opposition to coordinate cortical progenitor self-renewal and lineage commitment.
In conclusion, the CLOCK/BMAL1 complex controls cell cycle progression at the level of G2/M transition through regulation of Cyclin B1 expression.
Title: The positive circadian regulators CLOCK and BMAL1 control G2/M cell cycle transition through Cyclin B1.
Sirt1-Nrf2-Cyclin B1 signaling pathway is important for regulating oocyte meiosis and aging.
Title: Sirt1/Nrf2 pathway is involved in oocyte aging by regulating Cyclin B1.

Submit: New GeneRIF Correction See all GeneRIFs (53)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:498737 (e-PCR)
- UniSTS:498737

Ccnb1 (e-PCR), detects polymorphism
- UniSTS:498737

NoName (e-PCR)
- UniSTS:548203

PMC212738P2 (e-PCR)
- UniSTS:272028

Ccnb1-rs1 (e-PCR), detects polymorphism
- UniSTS:141253

Ccnb1-rs13 (e-PCR), detects polymorphism
- UniSTS:141254

D4Ertd639e (e-PCR), detects polymorphism
- UniSTS:167407

Ccnb1 (e-PCR), detects polymorphism
- UniSTS:531443

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables patched binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cell cycle phase transition	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic metaphase chromosome alignment	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic metaphase chromosome alignment	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in oocyte maturation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of attachment of spindle microtubules to kinetochore	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of fibroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mRNA 3'-end processing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial ATP synthesis coupled electron transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of chromosome condensation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitotic cell cycle spindle assembly checkpoint	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
part_of cyclin B1-CDK1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cyclin B1-CDK1 complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with mitochondrial matrix	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed
part_of outer kinetochore	ISO Inferred from Sequence Orthology more info
located_in spindle pole	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: G2/mitotic-specific cyclin-B1

Names: cyclin B1, related sequence 1; cyclin B1, related sequence 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172301.3 → NP_758505.2 G2/mitotic-specific cyclin-B1

See identical proteins and their annotated locations for NP_758505.2

Status: PROVISIONAL

Source sequence(s)

AC112701

Consensus CDS

CCDS36768.1

UniProtKB/Swiss-Prot

P24860

UniProtKB/TrEMBL

Q3TFV6, Q3TQW9, Q3UWL3

Related

ENSMUSP00000071989.9, ENSMUST00000072119.15

Conserved Domains (2) summary

pfam00134
Location:170 → 295

Cyclin_N; Cyclin, N-terminal domain

pfam02984
Location:297 → 415

Cyclin_C; Cyclin, C-terminal domain