U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Dusp29 dual specificity phosphatase 29 [ Mus musculus (house mouse) ]

    Gene ID: 435391, updated on 30-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Dusp29provided by MGI
    Official Full Name
    dual specificity phosphatase 29provided by MGI
    Primary source
    MGI:MGI:3647127
    See related
    Ensembl:ENSMUSG00000063821 AllianceGenome:MGI:3647127
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dupd1; EG435391
    Summary
    Enables MAP kinase phosphatase activity. Involved in glucose homeostasis; muscle cell differentiation; and negative regulation of ERK1 and ERK2 cascade. Located in cytoplasm and nucleus. Orthologous to human DUSP29 (dual specificity phosphatase 29). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 1.7), mammary gland adult (RPKM 0.7) and 5 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Dusp29 in Genome Data Viewer
    Location:
    14 A3; 14 11.82 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (21726605..21764644, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (21676565..21714576, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30363 Neighboring gene STARR-seq mESC enhancer starr_36134 Neighboring gene STARR-positive B cell enhancer ABC_E8945 Neighboring gene STARR-positive B cell enhancer ABC_E605 Neighboring gene STARR-positive B cell enhancer ABC_E4100 Neighboring gene K(lysine) acetyltransferase 6B Neighboring gene STARR-seq mESC enhancer starr_36143 Neighboring gene STARR-seq mESC enhancer starr_36148 Neighboring gene VISTA enhancer mm1600 Neighboring gene dual specificity phosphatase 13B Neighboring gene predicted gene 15935 Neighboring gene dual specificity phosphatase 13a

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Dual-specificity phosphatase 29 is induced during neurogenic skeletal muscle atrophy and attenuates glucocorticoid receptor activity in muscle cell culture. Cooper LM, et al. Am J Physiol Cell Physiol, 2020 Aug 1. PMID 32639872
    2. H19 lncRNA Promotes Skeletal Muscle Insulin Sensitivity in Part by Targeting AMPK. Geng T, et al. Diabetes, 2018 Nov. PMID 30201684, Free PMC Article
    3. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MAP kinase phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MAP kinase phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine/serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine/serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    dual specificity phosphatase 29
    Names
    dual specificity phosphatase DUPD1
    dual specificity phosphatase and pro isomerase domain containing 1
    NP_001013848.1
    NP_001405798.1
    XP_036014638.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013826.3 → NP_001013848.1  dual specificity phosphatase 29

      See identical proteins and their annotated locations for NP_001013848.1

      Status: VALIDATED

      Source sequence(s)
      AC148978, AC151533
      Consensus CDS
      CCDS26863.1
      UniProtKB/Swiss-Prot
      B2RW26, Q8BK84
      Related
      ENSMUSP00000073534.6, ENSMUST00000073870.7
      Conserved Domains (1) summary
      cd14575
      Location:44 → 203
      DUPD1; dual specificity phosphatase and pro isomerase domain containing 1

    2. NM_001418869.1 → NP_001405798.1  dual specificity phosphatase 29

      Status: VALIDATED

      Source sequence(s)
      AC148978, AC151533
      UniProtKB/Swiss-Prot
      B2RW26, Q8BK84

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      21726605..21764644 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158745.1 → XP_036014638.1  dual specificity phosphatase 29 isoform X1

      Conserved Domains (1) summary
      cd14575
      Location:55 → 214
      DUPD1; dual specificity phosphatase and pro isomerase domain containing 1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BK84.1 GenPept UniProtKB/Swiss-Prot:Q8BK84

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous