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    Mageb18 MAGE family member B18 [ Mus musculus (house mouse) ]

    Gene ID: 215641, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Mageb18provided by MGI
    Official Full Name
    MAGE family member B18provided by MGI
    Primary source
    MGI:MGI:3045344
    See related
    Ensembl:ENSMUSG00000067649 AllianceGenome:MGI:3045344
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B430216B18Rik
    Summary
    Predicted to be involved in negative regulation of transcription by RNA polymerase II. Located in cytoplasm. Is expressed in several structures, including brain; egg cylinder; gonad; heart; and liver. Orthologous to human MAGEB18 (MAGE family member B18). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Mageb18 in Genome Data Viewer
    Location:
    X C2- C3; X 40.62 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (91162485..91643178, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (92118879..92599572, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene melanoma antigen, family B, 5 pseudogene Neighboring gene melanoma antigen, family B, 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47541 Neighboring gene STARR-seq mESC enhancer starr_47542 Neighboring gene predicted gene 5941 Neighboring gene shugoshin 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47543 Neighboring gene STARR-seq mESC enhancer starr_47544 Neighboring gene predicted gene, 57676 Neighboring gene predicted gene, 25332

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The mouse Mageb18 gene encodes a ubiquitously expressed type I MAGE protein and regulates cell proliferation and apoptosis in melanoma B16-F0 cells. Lin Y, et al. Biochem J, 2012 May 1. PMID 22332604
    2. Expression dynamics of Mage family genes during self-renewal and differentiation of mouse pluripotent stem and teratocarcinoma cells. Gordeeva O, et al. Oncotarget, 2019 May 14. PMID 31143371, Free PMC Article
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. demonstrate that knockdown of MAGEB18 inhibits the growth of B16-F0 cells and induces apoptosis, which correlates with increased levels of TP53 (tumour protein 53), p21, Bax and caspase 3
      Title: The mouse Mageb18 gene encodes a ubiquitously expressed type I MAGE protein and regulates cell proliferation and apoptosis in melanoma B16-F0 cells.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    melanoma-associated antigen B18
    Names
    MAGE-B18 antigen
    melanoma antigen family B, 18

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173783.3 → NP_776144.1  melanoma-associated antigen B18

      See identical proteins and their annotated locations for NP_776144.1

      Status: VALIDATED

      Source sequence(s)
      AK046641
      Consensus CDS
      CCDS30268.1
      UniProtKB/Swiss-Prot
      Q8BQR7
      Related
      ENSMUSP00000109588.2, ENSMUST00000113955.2
      Conserved Domains (2) summary
      pfam01454
      Location:98 → 265
      MAGE; MAGE family
      pfam12440
      Location:5 → 77
      MAGE_N; Melanoma associated antigen family N terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      91162485..91643178 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BQR7.1 GenPept UniProtKB/Swiss-Prot:Q8BQR7

    Gene LinkOut

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