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    Serpinb1c serine (or cysteine) peptidase inhibitor, clade B, member 1c [ Mus musculus (house mouse) ]

    Gene ID: 380839, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Serpinb1cprovided by MGI
    Official Full Name
    serine (or cysteine) peptidase inhibitor, clade B, member 1cprovided by MGI
    Primary source
    MGI:MGI:2445363
    See related
    Ensembl:ENSMUSG00000079049 AllianceGenome:MGI:2445363
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EIC; ovalbumin
    Summary
    Predicted to enable peptidase inhibitor activity. Predicted to contribute to serine-type endopeptidase inhibitor activity. Involved in negative regulation of interleukin-1 beta production. Predicted to be located in cytoplasmic ribonucleoprotein granule and extracellular region. Predicted to be active in extracellular space. Is expressed in liver lobe. Orthologous to human SERPINB1 (serpin family B member 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in large intestine adult (RPKM 2.9), duodenum adult (RPKM 1.6) and 7 other tissues See more
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    Genomic context

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    See Serpinb1c in Genome Data Viewer
    Location:
    13 A3.2; 13 13.76 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (33065201..33126773, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (32881218..32940628, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Neighboring gene predicted gene, 35899 Neighboring gene nonconserved acetylation island sequence M71 enhancer Neighboring gene SCAN domain containing 3 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7220 Neighboring gene STARR-seq mESC enhancer starr_34105 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 6b Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:33096570-33096679 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 9 Neighboring gene predicted gene, 36181

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Multiparametric Evaluation of Post-MI Small Animal Models Using Metabolic ([(18)F]FDG) and Perfusion-Based (SYN1) Heart Viability Tracers. Kolanowski TJ, et al. Int J Mol Sci, 2021 Nov 22. PMID 34830471, Free PMC Article
    2. Enhanced egg-induced immunopathology correlates with high IFN-gamma in murine schistosomiasis: identification of two epistatic genetic intervals. Rutitzky LI, et al. J Immunol, 2005 Jan 1. PMID 15611268
    3. SERPINB1-mediated checkpoint of inflammatory caspase activation. Choi YJ, et al. Nat Immunol, 2019 Mar. PMID 30692621, Free PMC Article
    4. Characterization of four murine homologs of the human ov-serpin monocyte neutrophil elastase inhibitor MNEI (SERPINB1). Benarafa C, et al. J Biol Chem, 2002 Nov 1. PMID 12189154
    5. Comparison of human chromosome 6p25 with mouse chromosome 13 reveals a greatly expanded ov-serpin gene repertoire in the mouse. Kaiserman D, et al. Genomics, 2002 Mar. PMID 11863365

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Multiparametric Evaluation of Post-MI Small Animal Models Using Metabolic ([(18)F]FDG) and Perfusion-Based (SYN1) Heart Viability Tracers.
      Title: Multiparametric Evaluation of Post-MI Small Animal Models Using Metabolic ([(18)F]FDG) and Perfusion-Based (SYN1) Heart Viability Tracers.
    2. cDNA cloning, gene structure and biological characterization homologous to human MNEI
      Title: Characterization of four murine homologs of the human ov-serpin monocyte neutrophil elastase inhibitor MNEI (SERPINB1).
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC129308

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables peptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables serine-type endopeptidase inhibitor activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interleukin-1 beta production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of interleukin-1 beta production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in type B pancreatic cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    leukocyte elastase inhibitor C
    Names
    serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 1c
    serine (or cysteine) proteinase inhibitor, clade B, member 1c
    serine protease inhibitor EIC
    serpin B1c

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001384088.1 → NP_001371017.1  leukocyte elastase inhibitor C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL589871, AL606533, AL645693
      Conserved Domains (1) summary
      cl38926
      Location:1 → 306
      serpin; SERine Proteinase INhibitors (serpin) family

    2. NM_173051.2 → NP_766639.2  leukocyte elastase inhibitor C isoform 1

      See identical proteins and their annotated locations for NP_766639.2

      Status: VALIDATED

      Source sequence(s)
      AL606533, AL645693, BC104332, CJ203237
      Consensus CDS
      CCDS26429.1
      UniProtKB/Swiss-Prot
      Q5SV42, Q5SW82, Q8K3Y1
      Related
      ENSMUSP00000021834.4, ENSMUST00000021834.11
      Conserved Domains (1) summary
      cl00137
      Location:4 → 375
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      33065201..33126773 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516708.2 → XP_006516771.1  leukocyte elastase inhibitor C isoform X1

      Conserved Domains (1) summary
      cd19560
      Location:34 → 408
      serpinB1_LEI; serpin family B member 1 (serpin B1), leukocyte elastase inhibitor (LEI)

    2. XM_036158080.1 → XP_036013973.1  leukocyte elastase inhibitor C isoform X2

      Conserved Domains (1) summary
      cd19560
      Location:1 → 375
      serpinB1_LEI; serpin family B member 1 (serpin B1), leukocyte elastase inhibitor (LEI)

    3. XM_017315534.3 → XP_017171023.1  leukocyte elastase inhibitor C isoform X2

      Conserved Domains (1) summary
      cd19560
      Location:1 → 375
      serpinB1_LEI; serpin family B member 1 (serpin B1), leukocyte elastase inhibitor (LEI)

    4. XM_011244317.3 → XP_011242619.1  leukocyte elastase inhibitor C isoform X3

      Conserved Domains (1) summary
      cl38926
      Location:34 → 339
      serpin; SERine Proteinase INhibitors (serpin) family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5SV42.1 GenPept UniProtKB/Swiss-Prot:Q5SV42

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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